Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>ML335 is a selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), which is responsible for the degradation of endogenous cannabinoids. ML335 has been shown to inhibit FAAH with an IC50 value of 0.2 μM, and thereby increase the levels of endocannabinoids in mice and rats. This compound also binds to other basic proteins, including voltage-gated potassium channels, and may have analgesic effects as a result. The activation of these channels leads to increased neuronal excitability and pain relief. It is thought that ML335 could be used for chronic pain treatment due to its ability to inhibit FAAH and its downstream effects on other proteins.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Benzyl-5-iodopyridazin-3(2H)-one is an arylating agent that is used in the synthesis of pharmaceuticals and dyestuffs. The reaction is usually carried out at high temperatures, but can also be performed at room temperature. The product yield is usually high, but can be increased by using activated aryl halides as the starting material. The reaction temperature may require adjustment depending on the reactivity of the substituent groups present.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromo-4-(trifluoromethoxy)anisole is a chemical that is metabolized to the active metabolites 2-bromo-4-(trifluoromethoxy)-phenol and 4-(trifluoromethoxy)benzoic acid. These metabolites are conjugated with glucuronic acid and excreted in urine. The mechanism of action of 2-bromo-4-(trifluoromethoxy)anisole is not well understood, but it has been shown to be effective against Salicylic acid and salicylic acid conjugates. This chemical also has a radioactive component, which can be used for diagnostic purposes.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Racemic 5-Hydroxymethyl Tolterodine is an industrial chemical that can be used in the production of fesoterodine. It is a racemic form, which means it has two forms that are mirror images of each other, and cannot be separated. This chemical is produced by the reaction of tolterodine with acetone and isobutyric acid in an organic solvent. The yields are dependent on the type of reagents used, such as deacyl and intermediates. Racemic 5-Hydroxymethyl Tolterodine crystallizes as a white powder and has a melting point of 104°C. It can be chiral, meaning it has two different forms that are not superimposable on one another. Racemic 5-Hydroxymethyl Tolterodine utilises isobutyryl chloride as an intermediate in its synthesis process.br&gt;br&gt;</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(2-Methoxyethoxy)propanoic acid is a metabolite of clofibrate, a medication used to treat high cholesterol. It is also a metabolite of the drugs 2-methoxyethanol and 2-methoxyacetic acid. This metabolite has been shown to be an agonist for protein kinase C (PKC) isoforms alpha and gamma (PKA). It also acts as a monocarboxylic acid and has been shown to induce a syndrome in animals.</p>

<p>Versatile small molecule scaffold</p>

<p>5-(Chlorosulfonyl)-2-ethoxybenzoic acid is a synthetic drug that inhibits the enzyme phosphodiesterase type 5 (PDE5), which is responsible for degradation of cyclic guanosine monophosphate (cGMP). It has been shown to be effective in the treatment of erectile dysfunction, with improved efficacy and reduced side effects when compared to sildenafil. 5-(Chlorosulfonyl)-2-ethoxybenzoic acid belongs to a class of drugs called phosphodiesterase inhibitors. Studies have found that it increases the duration and quality of erections by inhibiting PDE5, an enzyme that breaks down cGMP. This inhibition leads to an increase in cGMP levels, which relaxes smooth muscle cells in the corpus cavernosum and causes increased blood flow into the penis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>