Reagentes Sintéticos

<p>Applications Synthetic pyrethroid insecticide, which acts as a potent inhibitor of calcineurin (protein phosphatase 2B) and has an IC50 of about 100pM. This inhibition action results in cellular hyperexcitability by causing non-mutated calcium channels to remain open for an extended period of time allowing an abundance of Ca2+ to enter the cell.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kavlock, R., et al.: J. Environ. Pathol. Toxicol., 2, 751 (1979), Enan, E., et al.: Biochem. Pharmacol., 43, 1777 (1992), Tan, J., et al.: Mol. Biol., 32, 445 (2002),<br></p>

<p>Applications 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (cas# 5807-14-7) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Grubbs Catalyst, 1st Generation is a ruthenium-based olefin metathesis catalyst.<br>References Rosen, E.L., et. al.: J. Organomet. Chem., 745 (2013)<br></p>

<p>Applications (Acetylacetonato)dicarbonylrhodium(I) involved in the preparation of rhodium chelating bisphosphate brigaded complex and use as hydroformylation catalysts.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bondzic. B.P., et al.: J. Mol. Catal. A: Chem., 423, 472-477 (2016)<br></p>

<p>Applications Acalabrutinib, is an experimental anti-cancer drug and a selective Bruton's tyrosine kinase (BTK) inhibitor. This kinase transmits signals from B-cell Receptor (BCR), and thus any genetic BTK mutation causes B-Cell immunodeficiency. Therefore, BTK inhibitors targeting B-cell signaling has shown great promise for the treatment of chronic lymphocytic leukemia (CLL).<br>References Byrd; et al. (2015). "Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia."; "AstraZeneca to buy Acerta for blood cancer drug". www.rsc.org. Chemistry World - Royal Society of Chemistry. Retrieved 24 December 2015.<br></p>

<p>Applications Arbutin is a glycosylated hydroquinone extracted from bearberry plant. Arbutin is a known inhibitor of tyrosinase, which in turn prevents the formation of melanin. Arbutin is often used as a skin-lightening agent in cosmetic products.<br>References Magnusson, B., et al.: J. Invest. Dermatol., 52, 268 (1969), Goodwin, B., et al.: Contact Dermatitis, 7, 248, (1981), ,Itoh, M., et al.: J. Dermatol., 9, 223 (1982), Sugimoto, K., et al.: Biol. Pharm. Bull., 24, 510 (2004)<br></p>

<p>Applications Calcium nitrate tetrahydrate is a chemical used in the manufacture of fertilizers.<br></p>

<p>Applications VX-765 shows anti-convulsant activity by inhibiting interlukin-1β biosynthesis.<br>References Maroso, M. et al.: Neurother., 8, 304 (2011); Galatsis, P. et al.: Bioorg. Med. Chem. Lett., 20, 5184 (2010);<br></p>

<p>Applications D-Cysteine is a strong inhibitor of Escherichia coli growth and also functions to provide inorganic sulfates for the sulfation of xenobiotics. D-Cysteine is a non-physiological isomer of L-Cysteine (C995000), and is not involved in protein or glutathione synthesis.<br>References Glazenburg, E., et al.: Biochem. Pharm., 33, 625 (1984); Klassen, C. &amp; Boles, J.: FASEB J., 11, 404 (1997); Soutourina, J., et al.: J. Biol. Chem., 276, 40864 (2001);<br></p>

<p>Applications An oral angiogenesis inhibitor targeting VEGFR and PDGFR.<br>References Olaussen, K., et al.: Oncogen., 28, 4249 (2009), Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009), Chan, A., et al.: Drugs, 69, 167 (2009),<br></p>

<p>Applications 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine, is a Anaplastic lymphoma kinase (ALK) inhibitor.<br>References Marsilje, T. H., et al.: J. Med. Chem., 56, 5675 (2013);<br></p>

<p>Applications Raclopride is a potent D2DR/D3DR antagonist.<br>References Ogren et al (1986) The selective dopamine D2 receptor antagonist raclopride discriminates between dopamine-mediated motor functions. Psychopharmacology 90 287. Hall et al (1989) Animal pharmacology of raclopride, a selective dopamine D2 antagonist. Psychopharmacol.Ser. 7 123. Seeman and Van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264.<br></p>

<p>Stability Hygroscopic<br>Applications (S)-3-Aminoazepan-2-one hydrochloride (cas# 26081-07-2) is a useful research chemical.<br></p>

<p>Stability Desiccate and Store at -20°C<br>Applications Kifunensine is an alkaloid produced by the fungus, Kitasatosporia kifunense, and has been shown to be a weak inhibitor of aryl mannosidase. It is a unique oxamide derivative of mannojirimycin and a potent inhibitor of the glycoprotein processing enzyme mannosidase I. Kifunenesine is ineffective in inhibiting either mannosidase II or the endoplasmic reticulum (ER) a-mannosidase. It also possesses immunomodulating properties based on chemical, physicochemical and x-ray crystallographic analysis.When tested in cell culture using influenza virus-infected MDCK cells, kifunensine, at 1 mg/ml or less, caused almost complete inhibition of complex chain formation with the accumulation of Man9(GlcNAc)2. Thus, kifunensine was proven to be 50 to 100 times more effective than deoxymannojirimycin.Ph<br>References Iwami, M., et al.: J. Antibiotic., 40, 612 (1987); Elbein, A.D., et al.: J. Biol. Chem., 265, 15599 (1990); Elbein, A.D., et al.: Archives of Biochem &amp; Biophys., 288, 1, 177 (1991); Kayakiri, H., et al.: Chem. Pharm. Bull., 39(6), 1378 (1991)<br></p>

<p>Applications Phosphoric Acid is used in various chemical processes as a phosphorylating compound. It is involved in the hydrolysis via phosphorylation of nanocrystals to obtain high-aspect-ratio cellulose nanocrystals. Also used in the synthesis of lithium-ion cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Camarero E. et al.: Biomacromol., 14, 1223 (2013); Meligrana, G. et al.: J. Power. Sources., 160, 516 (2006);<br></p>

<p>Stability Light Sensitive, Moisture Sensitive<br>Applications Mercury(II) thiocyanate (cas# 592-85-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-Mercapto-3-methylbutyl formate is one of the major odor-active thiol in pan-roasted white sesame seeds.<br>References Czerny, M., et al.: J .Agric. Food Chem., 47, 695 (1999), Steinhaus, M., et al.: Eur. Food Res. Technol., 226, 45 (2007), Tamura, H., et al.: Agric. Food Chem., 2010, 58, 7368 (2010),<br></p>

<p>Applications Tetrabutylammonium Acetate acts as a catalyst in organic syntheses of anion sensors.<br>References Gu, X. et al.: J. Mol. Liq., 222, 425 (2016); Bayindir, S. et al.: RSC Adv., 6, 72959 (2016);<br></p>

<p>Applications RK 33 is an inhibitor of DDX3, an ATP-dependent RNA helicase (1). Aberrant regulation of DDX3 is related to various diseases such as prostate and breast cancer (2). RK 33 was shown to decrease proliferation of prostate cancer cells and induced a G1 phase cell-cycle arrest (2).<br>References (1) Botlagunta, M. et al.: PLoS One. 6, e17563 (2011) (2) Xie, M., et al.: Cancer Res. 76, 6340 (2016)<br></p>

<p>Stability Hygroscopic<br>Applications Bifunctional DOTA conjugates to peptides and has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and therapeutic radiopharmaceuticals.<br>References Lewis, M., et al.: Bioconjug. Chem., 9, 72 (1998), Chappell, L., et al.: Bioorg. Med. Chem., 7, 2313 (1999), Prantner, A., et al.: Mol. Imaging, 2, 333 (2003), Allen, M., et al.: Chem. Biol., 11, 301 (2004), Weiner, R., et al.: BioDrugs, 19, 145 (2005), Breeman, W., et al.: Radionuclide Peptide Cancer Therapy, 119 (2006),<br></p>

<p>Applications N-Acetyl-L-(-)-leucine is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. Also used in the preparation of amphiphilic copolymers involving hydrophobic amino acid and oligopeptide side chains for optical tumor imaging in vivo.<br>References Zheng, C. et al.: Bioorg. Med. Chem. Lett., 22, 39 (2012); Miki, K. et al.: Bull. Chem. Soc. Jap., 85, 1277 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications Tadalafil. A phosphodiesterase 5 inhibitor.<br></p>

<p>Applications Castanospermine is a plant alkaloid shown to be a potent inhibitor of lysosomal a-or beta- glucosidase. It also inhibits mammalian glucosidase 1 and beta-mannosidase from sweet almonds and fungal beta-xylosidase.<br>References Arch. Biochem. Biophys., 221, 593 (1983), Clin. Biochem., 17, 3 (1984), Trends Bio. Sci., 9, 32, (1984), J. Biol. Chem., 260, 15873-15879 (1985), FEBS, 1985, 28 (1986)<br></p>

<p>Applications (S)-3-Aminopiperidin-2-one is used in preparation of Thiazoleurea derivatives for use as antitumor agents.<br>References Donald, E., et al.: PCT Int. Appl., (2020);<br></p>

<p>Applications Iodic Acid is used in the synthesis of silybin derivatives showing antiradical and antioxidant activities. Also used in the iodination of compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gazak, R. et al.: Bioorg. Med. Chem., 12, 5677 (2004); Zangade, S. et al.: Eur. j. Chem., 3, 314 (2012);<br></p>

<p>Applications STANNOUS OCTOATE (cas# 301-10-0) is a useful research chemical.<br></p>

<p>Stability Very Hygroscopic<br>Applications EDTA calcium disodium salt (cas# 62-33-9) is a useful research chemical.<br></p>

<p>Applications (R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol is proven to have amphetamine-like effects and is being used for recreational drug use. It is one of a new class of synthetic stimulants known as pipradol derivatives. It inibits neurite growth in PC12 cells which contributes to its neurotoxic effects. It is used as a reagent in the synthesis of (S)-duloxetine which is an antidepressant drug. It is used to prepare chiral Corey-Bakshi-Shibata catalyst which is used in organic synthesis.<br>References Coppola, M., et al.: Toxicol. Lett., 212, 57 (2012); Lee, S., et al.: B. Kor. Chem. Soc., 35, 1894 (2014); Kaizaki, A., J. Toxicol. Sci., 35, 375 (2010); Corey, E., et al.: J. Am Chem. Soc., 109, 5551 (1987);<br></p>

<p>Applications A selective inhibitor of BCL-2, in small cell lung cancer. ABT-737 induced dramatic regressions in tumors derived from some SCLC cell lines. Potent Bcl-2 Family inhibitor.<br>References Ikegaki, N., et al.: Cancer Res., 54, 6 (1994), Kaiser, U., et al.: Lung Cancer, 15, 31 (1996), Rudin, C., et al.: J. Clin. Oncol., 22, 1110 ( 2004), Konopleva, M., et al.: Cancer Cell, 10, 375 (2006), Trudel, S., et al.: Clin. Cancer Res., 13, 621 (2007),<br></p>

<p>Applications Inhibits bone resorption as a sodium salt and complexed with technetium Tc 99m for bone imaging. The monophosphonates are not active. Biphosphonates are used in disorders affecting the skeleton such as asteoporosis, metastatic disease, and Paget’s disease.<br>References Muhlbauer, R.C., et al.: J. Bone Miner. Res., 6, 1003 (1991), Pecherstorfer, M., et al.: J. Clin. Oncol., 14, 268 (1996),<br></p>

<p>Applications 4-[2-(Dimethylamino)ethoxy]benzylamine is an impurity of Itopride (HCl: I931500), a gastroprokinetic benzamide derivative that is used to treat patients with dyspepsia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Choung, R., et al.: Neuro. Motil., 19, 180 (2007); Iwanaga, Y., et al.: Jpn. J. Pharm., 66, 317 (1994)<br></p>

<p>Applications Monobenzyl Malonate is a useful synthetic intermediate. It was used to synthesize constrained cyclic agonists of the cholecystokinin CCK-B receptor. It was also used to prepare aspartate transcarbamoylase inhibitors.<br>References Blommaert, A., et al.: J. Med. Chem., 40, 647 (1997); Coudray, L., et al.: Bioorg. Med. Chem., 17, 7680 (2009)<br></p>

<p>Applications 1-(4-Methoxyphenyl)piperazine (cas# 38212-30-5) is a useful research chemical.<br></p>

<p>Applications N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine is a hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor used to increase white blood cell levels in blood and hematopoietic progenitor cells in bone marrow.<br></p>

<p>Applications An impurity found in amisulpride (A633250).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Analog of Cisplatin with reduced nephrotoxicity. Antineoplastic.<br>References Harland, S.J., et al.: Cancer Res., 44, 1693 (1984), Smith, I.E., et al.: Cancer Treat. Rep., 69, 43 (1985), Lygidakis, N.J., et al.: Interferon Cytokine Res., 15, 467 (1995),<br></p>

<p>Stability Hygroscopic<br>Applications Cerivastatin is a competitive inhibitor of HMG-CoA reductase.<br>References Ness, C.G., et al.: Arch. Biochem. Biophys., 325, 242 (1996), Steinke, W., et al.: Japan. Pharmacol. Ther., 24, Suppl. 9, S1217 (1996),<br></p>

<p>Applications Ammonium carbonate is a reagent that is used in the synthesis of D,L-Carbidopa (C175915 which is an inhibitor of aromatic amino acid decarboxylase.<br>References Sletzinger, M., et al.: J. Med. Chem., 6, 101 (1963),<br></p>

<p>Applications Carvedilol is a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is an antihypertensive used in the treatment of congestive heart failure.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990); Packer, M., et al.: N. Engl. J. Med., 334, 1349 (1996);<br></p>

<p>Stability Moisture Sensitive<br>Applications Has cytotoxicity and mutagenicity effects.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abril, N., et al.: Mutat. Res., 497, 111 (2001), Liu, L., et al.: Cancer Res., 62, 3037 (2002), Liu, L., et al.: J. Biol. Chem., 279, 4250 (2004), Marsch, G., et al.: Chem. Res. Toxicol., 17, 45 (2004),<br></p>

<p>Applications Sodium Pyrophosphate Decahydrate is a tetrabasic pyrophosphate salt used in buffers.<br></p>

<p>Applications Lumiracoxib is a selective cyclooxygenase-2-(COX-2) inhibitor and an anti-inflammatory agent (1,2,3,4).<br>References (1) Bitner, M., et al.: Int. J. Clin. Pract., 58, 340 (2004) (2) Packman, E., et al.: Headache, 45, 1163 (2005) (3) Rordorf, C.M., et al.: Clin. Pharmacokinet., 44. 1247 (2005) (4) Schnitzer, T.J., et al.: Curr. Med. Res. Opin., 21, 151 (2005)<br></p>

<p>Applications A novel nonsteroidal FXR nuclear receptor agonist.<br>References Makishima, M., et al.: Science, 284, 1362 (1999), Wang, H., et al.: Mol. Cell, 3, 543 (1999), Zhang, Y., et al.: J. Biol. Chem., 276, 43018 (2001), Carlton, V.E., et al.: Nat. Genet., 34, 91 (2003),<br></p>

<p>Applications 2-Chloro-4-iodoaniline (cas# 42016-93-3) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic<br>Applications Benzalkonium chloride (cas# 63449-41-2) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Flumazenil-D5 is a labelled analogue of Flumazenil (F500450), a benzodiazepine antagonist that can prevent or abolish (at the receptor level) the effects of a benzodiazepine.<br>References Brogden, R. &amp; Goa, K.: Drugs, 35, 448 (1988); Klotz, U. &amp; Kanto, J.: Clin. Pharmacokinet., 14, 1 (1988)<br></p>

<p>Applications Mepindolol is a non-selective β-adrenoceptor blocking agent. Mepindolol is used in the treatment of glaucoma.<br>References Luque Otero, M. et al.: Br. J. Clin. Pharmacol., 17, 361 (1984); Beckmann, R. et al.: Arzneim.-Forsch., 36, 811 (1986);<br></p>

<p>Applications (±)-trans-9,10-Epoxystearic Acid Methyl Ester is a useful synthetic intermediate. It is an intermediate used to prepare (±)-erythro- and (±)-threo-9,10-difluorostearic acids. It is also used to synthesize monofluorinated fatty acids.<br>References Tavasli, M., et al.: Chem. Commun., 11, 1226 (2002); Buist, P., et al.: J. Chem. Soc., 17, 2617 (1997);<br></p>

<p>Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>

<p>Applications Calcium Carbonate is a common chemical reagent used in various organic reactions. It is used in the synthesis of small molecules which disrupt Wnp-dependent signalling in tissue regeneration and cancer. Also used in the preparation of non-cytotoxic, silver nanoparticle-polysaccharide nanocomposites shown to provide antimicrobial activity.<br>References Chen, B. et al.: Nat. Chem. Biol., 5, 100 (2009); Travan, A. et al.: Biomacromol., 10, 1429 (2009);<br></p>

<p>Applications Trimethylamine is used as a reagent in the synthesis of L-Carnitine (C184110); an essential cofactor of fatty acid metabolism. L-Carnitine is required for the transport of fatty acids through the inner mitochondrial membrane and is synthetized primarily in the liver and kidney.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004); Wu, J., et al.: Faming Zhuanli Shenqing. CN 104030934 A 20140910. Sep 10, 2014<br></p>

<p>Applications It is an α2 receptor agonist. It is a drug used to treat glaucoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Katz, L.J., et al.: Am. J. Ophthalmol., 127, 20 (1999), Cantor, L. B., Expert Opin. Pharmacother., 1, 815 (2000),<br></p>

<p>Applications Dofetilide is a potassium channel blocker. Antidysrhythmic drug.<br>References Carmeliet, D., et al.: J. Pharmacol. Exp. Ther., 262, 809 (1992); Norgaard, B.L., et al.: Am. Heart J., 137, 1062 (1999); Torp-Pedersen, C., et al.: N. Engl. J. Med. 341, 857 (1999);<br></p>

<p>Applications Tetramethylammonium Hydroxide Pentahydrate is a useful compound for preparing gamma-cesium lead iodide films for high-efficiency deep-red light-emitting devices.<br>References Yi, C., et al.: Nat. Commun., 11, 4736 (2020)<br></p>

<p>Applications A farnesyltransferase inhibitor. Sensitizes human multiple myeloma cell to proteasome inhibition by blocking degradation of bortezomib(B675700)-induced aggresomes. Also shown to inhibit the growth of myeloid leukemia cell lines and primary leukemia cells by inducing apoptosis and cell-cycle blockage when combined with rapamycin(R124000).<br>References David, E., et al.: Blood, 116, 5285 (2010); Nagai, T., et al.: Leukemia Res., 34, 1057 (2010); Hong, D., et al.: Clin. Cancer Res., 15, 7061 (2009)<br></p>

<p>Applications AZD-9291 Mesylate is a potent and selective epidermal growth factor receptor (EGFR) inhibitor.<br>References Finlay, M.; et al.: J. Med. Chem., 57, 8249 (2014)<br></p>

<p>Applications Sodium dichloroacetate is an inhibitor of mitochondrial pyruvate dehydrogenase kinase.<br></p>

<p>Applications Bis(1,5-cyclooctadiene)diiridium(I) Dichloride is a catalyst used in the iridium-catalyzed asymmetry hydrogenation of unfunctionalized exocyclic double carbon bonds. Also, it is used to test new NeoPHOX ligands derived from serine or threonine.<br>References Xia, J., et al.: Chem. Eur. J., 22, 18354-18357 (2016); Padevet, J., et al.: Beilstein J. Org. Chem., 12, 1185-1195 (2016)<br></p>

<p>Stability Hygroscopic<br>Applications 6-Amino-2-hydroxymethyl Hexan-1-ol (cas# 125162-81-4) is a compound useful in organic synthesis.<br>References Rubina, A., et al.: Anal. Biochem., 325, 92 (2004),<br></p>

<p>Applications 4-Aminobutylcarbamic Acid tert-Butyl Ester is used in the synthesis of iron chelators expressing antitumor activity. Also used in the synthesis of iron oxide nanoparticles which are used in cellular and small animal imaging.<br>References Corce, V. et al.: Bioconj. Chem., 25, 320 (2014); Stanicki, D. et al., J. mat. Chem. B. Mat. Biol. Med.: 2, 387 (2014);<br></p>

<p>Applications Carmofur is a derivative of fluorouracil (F596002) an is an antineoplastic agent showing antitumor activity against several cells including L1210 leukemia and L5178Y lymphoma cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hoshi, A., et al.: J. Pharmacobio-dynam., 3, 478 (1980);<br></p>

<p>Stability Hygroscopic<br>Applications Tetrahydrobiopterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin, melatonin, dopamine, norepinephrine , epinephrine, and is a cofactor for the production of nitric oxide by the nitric oxide synthases. Chemically, its structure is that of a reduced pteridine derivative.<br>References Levy, Harvey L., et al.: Lancet,  370, 504 (2007); Isojima, Yasushi., et al.: Proc Natl Acad Sci USA .,106, 15744 (2009); Burton, B. K., et al.: J. Inherit. Metab. Dis., 30, 700 (2007)<br></p>

<p>Applications Ammonium iron(III) citrate (cas# 1185-57-5) is a useful research chemical.<br>Chemical Name: Ammonium iron(III) citrate (cas# 1185-57-5) is a useful research chemical.<br></p>

<p>Applications Cupriethylenediamine Hydroxide is used as a solvent for cellulose.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yang, L., et al.: J. Applied Polym. Sci., 126, E244 (2012); Shi, W., et al.: Ind. Eng. Chem. Res., 52, 586 (2013); Cyrot, J., et al.: Bulletin de l'Institut Textile de France, 18, 211 (1964)<br></p>

<p>Applications 2-Chlorophenylboronic Acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.<br>References Kang, S., et al.: J. Med. Chem., 57, 5293 (2014);<br></p>

<p>Applications Cyclosporin is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>

<p>Stability Hygroscopic<br>Applications Sodium hexacyanoferrate(II) decahydrate is being used and studied as a possible cathode material for sodium ion batteries.<br>References Piernas-Munoz, J.M., et al.: Electrochim. Acta., 200, 123-30 (2016);<br></p>

<p>Applications 2-Methylisoborneol solution - (CAS# 2371-42-8) is a useful research chemical compound.<br></p>

<p>Applications D,L-2-Amino-3-phosphonopropionic acid is a phosphonate substituted derivative of Aspartic acid (A788955) and is a known antagonist of a receptor that is coupled to phosphoinositide metabolism in brain slices. D,L-2-Amino-3-phosphonopropionic acid is also an inhibitor of metabotropic glutamate receptors in rat brain.<br>References Hedberg, T. &amp; Stanton, P.: Eur. J. Pharma., 310, 19 (1996); Saugstad, J., et al.: Eur. J. Pharm.: Mol. Pharm., 289, 395 (1995); Schoepp, D., et al.: Mol. Pharm., 38, 222 (1990)<br></p>

<p>Applications An aldose reductase inhibitor. It is used in treatment of diabetic neuropathy.<br>References Terashima, H., et al.: J. Pharmacol. Exp. Ther., 229, 226 (1983), Kikkawa, R., et al.: Diabetologia, 24, 290 (1983), Kojima, K., et al.: Jpn. J. Ophthalmol., 29, 99 (1985),<br></p>

<p>Applications Zaltoprofen is a non-steroidal anti-inflammatory drug. It inhibits bradykinin-induced pain responses without blocking bradykinin receptors.<br>References Hirate, K., et al.: Nerosci. Res., 54, 288 (2006); Yamamoto, M., et al.: Chirality, 2, 280 (1990); Inoue, M., et al.: J Pharmacol. Exp. Ther., 293, 662 (2000); Graven-Nielsen, T., et al.: Clin. J. Pain, 17, 2 (2001)<br></p>

<p>Applications Deshydroxyethoxy Ticagrelor analog of Ticagrelor (T437700) an antiplatelet agent, and preventative in the treatment of heart attacks, myocardial infarction, and other pulmonary diseases.<br>References Zhang, H. et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications Tauro-β-muricholic Acid Sodium Salt is the salt form of Tauro-α-muricholic Acid which is a bile acid released by the liver and is typically used in cholestasis studies.<br>References Yang, L. et al.: Chem. Res. Toxicol., 21, 2280 (2008); Holm, R. et al.: Phys. Chem. Chem. Phys., 11, 5070 (2009);<br></p>

<p>Applications Synthetic keto-derivative of Petromyzonol (P293500), a bile salt derivative isolated from the sea lamprey (Petromyzon marinus ) ammocoete (larval form). May be used to study the biochemical characteristics of these and other compounds containing the allocholic acid ring nucleus.<br>References Haslewood, G., et al.: Biochem. J., 114, 179 (1969); Sorensen, P.W., et al.: J. Gen. Physiol., 105, 569 (1995), Krasowski, M., et al.: Mol. Endocrinol., 19, 1720 (2005),<br></p>

<p>Applications 5-Methyl-4-nitroimidazole can cause mutations with Klebsiella pneumonia and Salmonella typhimurium.<br>References Voogd, C.E., et. al.: Mutat. Res. Genet. Tox. Testing, 66, 207 (1979); Kramers, P.G.N.: Mutat. Res. Genet. Tox. Testing, 101, 209(1982)<br></p>

<p>Applications A potent, selective and orally active cysteinyl leukotriene type 1 receptor antagonist. Used as an antiasthmatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Matassa, V.G., et al.: J. Med. Chem., 33, 1781 (1990), Findlay, S.R., et al.: J. Allergy Clin. Immunol., 89, 1040 (1992), Krell, R.D., et al.: Am. Rev. Respir. Dis., 141, 978 (1990), Dunn, C.J., Drugs, 61, 285 (2001),<br></p>

<p>Applications An antitussive.<br>References Yamatsu, et al.: Jpn. J. Pharmacol., 17, 538 (1967), Tellini, N., et al.: Boll. Chim. Farm., 109, 476 (1970),<br></p>