Reagentes Sintéticos

<p>Applications (S,S)-2,3-Butanediol is the (S,S)-isomer of 2,3-Butanediol (B690020), a naturally occurring compound found in cocoa butter.<br>References Wang, Yu., et al.: J. Biological. Chem., 289, 6080 (2014); Cheng, C., et al.: J. Org. Chem., 78, 8562 (2013);<br></p>

<p>Applications Sodium Thiocyanate is used widely in chemical synthesis as source of thiocyanate anion such as in the conversion of alkyl halides to alkylthiocyanates.<br>References Shriner, R., et al.: Org. Synth., 2, 11 (1931);<br></p>

<p>Applications meso-Tetra (N-methyl-4-pyridyl) porphine tetrachloride is a synthetic porphyrin for research use.<br></p>

<p>Applications Ciproxifan is a potent histamine H3 receptor antagonist which affects histamine levels in the brain. It may be used in treatments for sleep and neurological disorders.<br>References Stark, H. et al.: J. Med. Chem., 43, 3987 (2000); Mahmood, D. et al.: Pharmacolol. Rep., 64, 191 (2012); Passani, M. et al.: Trends Pharmacol. Sci., 25, 618 (2004);<br></p>

<p>Applications BGJ 398 is a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.<br>References Guagnano, V., et al.: J. Med. Chem., 54, 7066 (2011); Konecny, G., et al.: Mol. Cancer Ther., 12, 632 (2013)<br></p>

<p>Applications (-)-B-Methoxydiisopinocampheylborane hydrate is an intermediate used in the synthesis of homoallylic alcohol's and several complex natural products.<br>References Mishra, V. K., et al.: J. Org. Chem., 81, 9728 (2016); Jonnalagadda, S. C., et al.: e-EROS Encyclopedia of Reagents for Organic Synthesis 1, (2009); Bailey, A. M., et al.: Angew. Chem. Int. Ed., 55, 639 (2016)<br></p>

<p>Applications Ammonium Bicarbonate is a useful reagent in the synthesis of double-shelled CoMn2O5 hollow microcubes used as anode material for lithium-ion batteries.<br>References Zhou, L., et al.: Adv. Mater., 24, 745 (2012);<br></p>

<p>Applications γ-Butyrobetaine is a synthetic carnitine related compound used as a transporter substrate in the cloning and sequencing of human carnitine transporter 2 (CT2).<br>References Enomoto, A. et al.: J. Biol. Chem., 277, 36262 (2002);<br></p>

<p>Applications Used in the preparation of antibacterial oxazolidinones.<br>References Kim, J. et al.: 19, 550 (2009); Michael R. et al.: J. Med. Chem., 50, 5886 (2007)<br></p>

<p>Applications Magnesium tert-Butoxide is a reagent used in deprotonation reactions in organic synthesis. A mild alkaline earth metal alkoxide base that also functions as a Lewis acid and Bronsted base in chemical transformations.<br>References Ponikiewski, L., et al.: Z. Anorg. Allg. Chem., 634, 1770 (2008); Roman, D. S., et al.: e-EROS Encyclopedia of Reagents for Organic Synthesis, 1 (2013)<br></p>

<p>Applications WAY-100635 Maleate Salt is a selective SR-2B antagonist. It can be used in biological study of drug effects viewed from a signal transduction network perspective.<br>References Fliri, A., et al.: J Med Chem, 52, 8038 (2009)<br></p>

<p>Stability Hygroscopic<br>Applications XL413 is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Koltun, E., et al.: Bioorg. Med. Chem. Lett., 22, 3727 (2012)<br></p>

<p>Applications 3-Pyridinemethanol is a useful synthetic intermediate. It can be used in the synthesis of histone deacetylase inhibitors. It can also be used to prepare (phenyl)(cyanopyrazinyl)urea derivatives as possible kinase-1 (Chk1) inhibitors.<br>References Suzuki, T., et al.: J. Med. Chem., 42, 3001 (1999); Li, G., et al.: Bioorg. Med. Chem. Lett., 16, 2293 (2006)<br></p>

<p>Applications Tin(II) trifluoromethanesulfonate (cas# 62086-04-8) is a useful research chemical.<br></p>

<p>Applications 3-Phenylpropyne is a useful synthetic intermediate. It is an intermediate used to synthesize carlina oxide. It can also be used to prepare triazole substituted pyrazolopyrimidinamide derivatives via click chemistry as potential inhibitors of the Plasmodium falciparum PfPK7 protein kinase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Klein, M., et al.: Org. Biomol. Chem., 7, 3421 (2009)<br></p>

<p>Applications Ammonium Vanadium Oxide is used in pharmaceutical composition of metformin decavanadate for prevention and treatment of metabolic syndrome, obesity and diabetes. Chimeric design, synthesis, and biological assays of new nonpeptide insulin-mimetic vanadium compounds to inhibit protein tyrosine phosphatase 1B.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Scior, T., et al.: Drug Des. Devel. Ther., 4, 231 (2010); Gonzalez V., et al.: Pat. Appl. (2016), MX 2015003461 A 20160919;<br></p>

<p>Applications Magnesium Bromide Hexahydrate is an inorganic salt used in the synthesis of superconductors and nanowires. Also present in polymer nanocomposites to improve conductivity.<br>References Alam, M. et al.: Polym. Int., 63, 1465 (2014); McDonald, T. et al.: J. Am. Chem. Soc., 135, 7056 (2012);<br></p>

<p>Applications A non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation. It becomes active after metabolism in the body and inhibits the activation of cyclooxygenase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Masahide H. et al.: J Clin Biochem Nutr., 47, 138 (2010); Noguchi, M. et al.: Biolog. Pharmac. Bull., 28, 2075 (2005); Hyun, J. et al.: Arch. Pharm. Res., 24, 541 (2001);<br></p>

<p>Applications Diethyl Diethylmalonate is an intermediate in the synthesis of Barbital (B118500), a prototype of the barbiturate hypnotics.<br>References Kholod, Y., et al.: Environ. Sci. Technol., 43, 9208 (2009); Yu, J., et al.: Pharm. Res., 27, 457 (2010); Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010)<br></p>

<p>Applications 2-(Di-tert-butylphosphino)-1,1'-binaphthyl 98% TrixiePhos is a reagent used as ligand in palladium-catalyzed C-O, C-N, and C-C bond forming reactions.<br>References Tsvelikhovsky, D., et al.; J. Am. Chem. Soc., 132, 14048 (2010); Eidamshaus, C., et al.: e-EROS Encyclopedia of Reagents for Organic Synthesis, 1 (2014); Tsvelikhovsky, D., et al.: J. Am. Chem. Soc., 134, 16917 (2012)<br></p>

<p>Applications A useful synthetic intermediate. Used for asymmetric hydroxylation.<br>References Davis, F.A., et al.: J. Am. Chem. Soc., 112, 6679 (1990)<br></p>

<p>Applications SKF 81297C is a dopamine D1 agonist (1).<br>References (1) Bergman, J., et. al.: J. Pharmacol. Exp. Ther., 273, 40 (1995)<br></p>

<p>Applications 4-Bromobenzotrifluoride is an aromatic compound that is used as a reagent to synthesize Bergenin (B318650), a compound that originates in Mallotus japonicus that exhibits hepatoprotective and antioxidant effects. 4-Bromobenzotrifluoride is also used as a reagent to prepare (±)-Preclamol, a partial dopamine D2 agonist that is used to treat Parkinson’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lim, H., et al.: Pharmacology, 63, 71 (2001); Parkan, K., et al.: Chem. Eur. J., 20, 4414 (2014); Pirtosek, Z., et al.: Clin. Neuro., 16, 550 (1993); Takahashi, H., et al.: Bioorg. Med. Chem., 11, 1781 (2003); Vasdev, N., et al.: Synapse, 60, 314 (2006)<br></p>

<p>Applications JNJ 17203212 is a high affinity TRPV1 receptor antagonist.<br></p>

<p>Applications Methyl Dimethoxyacetate is used as a reagent in the synthesis of benzimidazole derivatives for use as respiratory syncytial virus inhibitors.<br>References Cooymans, Ludwig Paul; D., et al. PCT Int. Appl. WO 2012080446 A1 20120621. Jun 21, 2012<br></p>

<p>Applications GSK 2606414 acts as a potent and selective inhibitor of protein kinase R and similarly endoplasmic reticulum kinase affecting numerous diseases such as cancer.<br>References Axten, J. et al.: J. Med. Chem., 55, 7193 (2012);<br></p>

<p>Applications 4-Nitro-benzeneethanol is a useful synthetic intermediate. It can be used to synthesize N-phenylethylindole carboxamides as SAR study of allosteric modulators of CB1 receptor. It can also be used to prepare 2-aza-2'-deoxyinosine-containing oligodeoxyribonucleotide duplexes.<br>References Piscitelli, F., et al.: J. Med. Chem., 55, 5627 (2012); Acedo, M., et al.: J. Org. Chem., 60, 6262 (1995)<br></p>

<p>Stability Hygroscopic<br>Applications Ethoxyamine Hydrochloride acts as a reagent in the preparation of biflorin derivatives (hydrazones, oximes, terpene ketones) and determination of their activity as antibacterial and anticancer agents.<br>References Souza, L. G., et al.: Bioorg. Med. Chem. Lett., 26, 435 (2016)<br></p>

<p>Applications 4-Nitrobenzoyl Chloride is used inorganic syntheses such as Michael additions. Also used in the synthesis of polysubstituted furanonaphthoquinoines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhong, J. et al.: Catal. Comm., 32, 18 (2013); Wu, Z. et al.: Org. Biomol. Chem., 11, 828 (2013);<br></p>

<p>Applications Sodium Metasilicate is an antibacterial pharmaceutical compound containing Sodium Hydrogen Carbonate.<br>References Karaagac, M., et al.: Turk. Pat. Appl., (2017);<br></p>

<p>Applications 3,5-Dibromobenzaldehyde is a dibrominated benzaldehyde that is a very useful building block for the preparation of a wide range of biologically active compounds such as a antibacterials<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nielsen, S. et al.: Bioorg. Med, Chem., 12, 3017 (2004); Balderamos, M. et al.: Exp. Biol. Med., 233, 1395 (2008);<br></p>

<p>Applications (+/-)-Nutlin-3 is a small molecule MDM2 antagonist.<br>References Vassilev, L.T., et. al.: Sci., 303, 844 (2004)<br></p>

<p>Applications α-Acetoxyacetic Acid, is a versatile organic building block, used in the synthesis of pharmaceutical compounds, including inhibitors and therapeutic agents. It can be used for the synthesis of analogs of 5-Aminolevulinic Acid, which are potential inhibitors of ALA dehydratase (porphobilinogen synthase), an early enzyme of tetrapyrrole biosynthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Appleton, D., et al.: J. Chem. Soci., Perkin Transactions , 1, 89 (1998);<br></p>

<p>Applications Intermediate for the synthesis of enantiopure substituted 1,4-Dioxanes. Extremely valuable and versatile alcohol used as a chiral building block in organic synthesis.<br>References Bagnoli, L., et al.: Chem. Eur. J., 17, 993 (2011)<br></p>

<p>Applications 4-Formyl-2-nitrophenol is an Intermediate used in synthesis of novel amodiaquine analogs as potential antimalarial and antifilarial compounds.<br>References Jiang, D.X., et al.: Int. J. Environ. Res., 5, 923 (2011); Al-Zereini, W., et al.: J. Antibiotic., 63, 297 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications Plerixafor Hydrochloride (1:8), is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients. It is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>

<p>Applications Alpha-(trifluoromethyl)styrene<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-(1,3-Dioxolan-2-yl)ethyltriphenylphosphonium Bromide (cas# 86608-70-0) is a useful research chemical.<br></p>

<p>Applications 5-Chloropent-1-yne is an intermediate in the synthesis of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>

<p>Applications 4-(Bromomethyl)benzoic Acid Methyl Ester is an ester derivative of a bromoalkylated benzoic acid. 4-(Bromomethyl)benzoic Acid Methyl Ester is used in the preparation of potential anti-HIV agents. It is also used as a catalyst for rearrangement of benzylthiothiazoline derivatives in the preparation aldose reductase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cushman, M. et al.: Bioorg. Med. Chem. Lett., 8, 833 (1998); Nagao, Y. et al.: Chem. Pharmac. Bull., 36, 509 (1988);<br></p>

<p>Stability Hygroscopic<br>Applications 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one is involved in the pharmacological inactivation of Skp2 E3 ligase.<br>References Chan, C., et al.: Cell, 154, 556-568 (2013)<br></p>

<p>Applications 1,2,4,5-BENZENETETRACARBOXYLIC ACID (cas# 89-05-4) is a useful research chemical.<br></p>

<p>Applications Silver Carbonate is used in organic synthesis in the Koenigs-knorr glycosylation reaction. It is also known as Fetizon's reagent acting as an oxidising agent on celite forming lactones form diols.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fetizon, M., et al.: J. Chem. Soc. Chem. Comm., 19, 1118 (1969);<br></p>

<p>Applications 1-Bromo-3,5-difluorobenzene is used in the synthesis of selective antagonists of GluN2C/GluN2D is used in the synthesis of COX-2 inhibitors as anti-inflammatory agents and anti-cancer agents.<br>References Khanna, I. et al.: J. Med. Chem., 40, 1634 (1997); Pommery, N. et al.: J. Med. Chem., 47, 6195 (2004);<br></p>

<p>Applications 2-Methoxybenzoyl Chloride is an aromatic acyl chloride derived from anisic acid. 2-Methoxybenzoyl Chloride is used in the preparation of a wide range of compounds such as anti-virals, anti-bacterials and antitumor agents.<br>References Li, Z. et al.: Chem. Biol. Drug Des., 79, 1018 (2012); Liu, W. et al.: Huax. Tong., 74, 665 (2011); Sousa, E. et al.: Eur. J. Med. Chem., 44, 3830 (2009);<br></p>

<p>Applications Cyclopropylacetylene is used in a variety of chemical reactions in organic syntheses. Used in the synthesis of BACE1 inhibitors used in the treatment of Alzheimer’s disease. It is also used in cycloaddition reactions and the synthesis of fluoromethylsydnones.<br>References Xu, Y. et al.: Bioorg. Med. Chem. Lett., 23, 3075 (2013); Foster, R. et al.: J. Org. Chem., 78, 4049 (2013);<br></p>

<p>Impurity Atomoxetine EP Impurity D<br>Applications m-Methyl Atomoxetine Hydrochloride (Atomoxetine EP Impurity D) is an impurity of Atomoxetine (A791400), a norepinephrine reuptake inhibitor.<br>References Farid, N.A., et al.: J. Clin. Pharmacol., 25, 296 (1985), Gehlert, D.R., et al.: J. Neurochem., 64, 2792 (1995), Hwamg. et al.: Neurosci. Lett., 265, 151 (1999), Ring, B.J., et al.: Drug Metab. Dispos., 30, 319 (2002),<br></p>

<p>Applications Aclidinium Bromide is a novel long-acting antimuscarinic bronchodilator in phase II clinical trials for the treatment of chronic obstructive pulmonary disease (1,2).<br>References (1) Gupta, V. and Singh, D.: Expert Rev Respir Med. 6, 581 (2012) (2) De La Motte, S., et al.: Int. J. Clin. Pharmacol. Therap., 50,403 (2012)<br></p>

<p>Applications 4-(4-Boc-piperazine-1-carbonyl)phenylboronic acid pinacol ester<br></p>

<p>Applications (3R,5R)-Atorvastatin Sodium Salt is an Atorvastatin impurity in bulk drug and tablets.<br>References Posvar, E., et al.: J. Clin. Pharmacol., 36, 728 (1996), Lea, A., et al.: Drugs, 53, 828 (1997), Miao, X., et al.: J. Chromatogr., 998, 133 (2003),<br></p>

<p>Applications 2-(7-methyl-2-oxo-2H-chromen-4-yl)acetic Acid (cas# 50402-83-0) is a useful research chemical.<br></p>

<p>Applications 1-(Tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (cas# 903550-26-5) is a useful research chemical.<br></p>

<p>Applications 4-Methoxyindole is a reactant for alpha-ethyltryptamines as dual dopamine-serotonin releasers.<br>References Blough, B. E., et al.: Bioorg. Med. Chem. Lett., 24, 4754 (2014)<br></p>

<p>Applications Hoveyda-Grubbs Catalyst 1st Generation is a ruthenium-based olefin metathesis catalyst.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kingsbury, J.S. et al.: Journal of the American Chemical Society, 121, 791 (1999);<br></p>

<p>Applications (-)-O,O’-Di-p-toluoyl-L-tartaric Acid (cas# 32634-66-5) is a compound useful in organic synthesis.<br></p>

<p>Stability Volatile<br>Applications Allyltrimethylsilane is used in the allylation of aldehydes, imines, allylic and benzylic alcohols, and chiral α-keto-amides that are derived from (S)-proline esters.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yadav, J.S., et al.: Tetrahedron Lett., 43, 3783 (2002); Aggarwal, V.K., et al.: Tetrahedron Lett., 37, 3745 (1996); Wang, D.K., et al.: J. Org. Chem., 64, 4233 (1999); Kaur, G., et al.: Tetrahedron Lett., 38, 2521 (1997); Soai, K., et al.: J. Chem. Soc., Chem. Commun., 15, 1016 (1984)<br></p>

<p>Applications GBR-12909 is a potent dopamine transport blocker studied extensively in rats; it has also been classified as being able to release norepinephrine more potently than it releaes dopamine and seratonin in biological studies.<br>References Rothman, R.B.; et al.: Synapse, 39, 32 (2001)<br></p>

<p>Applications 1,2-Diaminopropane-N,N,N',N'-tetraacetic Acid is an aminopolycarboxylic acids found at ultra-trace levels in water; Also, it is used in the construction of Eu3+ ion-selective membrane electrode as suitable ionophore.<br>References Nette, D., et al.: Anal. Chim. Acta, 884, 124-132 (2015); Abedi, M. R., et al.: E-J. Chem., 8, S467-S473 (2011)<br></p>

<p>Applications Multi-drug resistance (MDR) modulator; selective inhibitor of P-glycoprotein (P-gp). Antineoplastic adjunct (chemosensitizer).<br>References Green, L.J., et al.: Biochem. Pharmacol., 61, 1393 (2001), Shepard, R.L., et al.: Int. J. Cancer, 103, 121 (2003),<br></p>

<p>Applications Sumanirole is a high affinity D2 receptor agonist (EC50 values are between 17 and 75 nM in cell-based assays). Sumanirole displays &gt;200-fold selectivity for the D2 receptor against other dopamine receptor subtypes (Ki values are 9.0, 1940, &gt;2190 and &gt;7140 for D2, D3, D4 and D1 receptors respectively). Sumanirole exhibits antiParkinsonian activity similar to Ropinirole (R641000).<br>References McCall, et al.: J. Pharmacol. Exp. Ther., 314 1248 (2005), Stephenson, et al.: J. Pharmacol. Exp. Ther., 314 1257 (2005),<br></p>

<p>Applications Methyl 8-Chloro-8-oxooctanoate is used as a reagent in the synthesis of β-cyclodextrin-6-deoxy-6-NHC(O)(CH2)6C(O)NHOH which is a β-cyclodextrin-capped histone deacetylase inhibitor that may have potential for use in treatment of cancers and inflammatory diseases. It is also used in one synthetic route for tubacin which is a known anticancer agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Amin, J., et al.: Bioorg. Med. Chem. Lett., 23, 3346 (2013); Hong, J., et al.: Lett. Org. Chem., 7, 50 (2010);<br></p>

<p>Applications Entinostat is an emerging HDACi (histone deacetylase inhibitor). Entinostat is used for treatment of solid tumors and hematologic malignancies. Potent Histone deacetylase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hu, E., et al.: J. Pharmacol. Exp. Ther., 307, 720 (2003), Maggio, S., et al.: Cancer Res., 64, 2590 (2004), Gojo, I., et al.: Blood, 109, 2781 (2007), Xu, W; Oncogene, 26, 5541 (2007),<br></p>