Padrões Farmacêuticas

<p>Impurity Artemether USP Related Compound B<br>Applications Derivative of Artemisinin (A777500). Shows antimalarial and antifungal activity.<br>References Michael, O., et al.: Malaria J., 9, 335 (2010), Cesar, I., et al.: J. Pharm. Biomed. Anal., 54, 114 (2011), Galal, A. et al.: J. Nat. Prod. 68, 1274 (2005)<br></p>

<p>Applications DL-Methionine methylsulfonium chloride (cas# 3493-12-07) is a useful research chemical.<br></p>

<p>Applications Dihydro Artemisinin (D448360) dimer with anticancer and antiprotozoal activity.<br>References Galal, A. et al.: Bioorg. Med. Chem., 17, 741 (2009); Beekman, A. et al.: Phytother. Res., 10, 140 (1996)<br></p>

<p>Applications Labelled Vanillin. Occurs naturally in a wide variety of foods and plants such as orchids; major commercial source of natural vanillin is from vanilla bean extract. Synthetically produced in-bulk from lignin-based byproduct of paper processes or from guaicol.<br>References Jenner, P.M., et al.: Food Cosmet. Toxicol., 2, 327 (1964), Clark, G.S., et al.: Perfum. Flavor., 15, 45 (1990),<br></p>

<p>Applications Derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant.<br>References Hombhanje, F., et al.: Pharma., 3, 3581 (2010), Michael, O., et al.: Malaria J., 9, 335 (2010), Cesar, I., et al.: J. Pharm. Biomed. Anal., 54, 114 (2011),<br></p>

<p>1-(3,4-Methylenedioxyphenyl) 2-nitropropene (1-MPNP) is a phosphatase inhibitor that is active against gram-negative bacteria by inhibiting enterotoxins and chlamydia. 1-MPNP inhibits the activity of tyrosine phosphatases, which are enzymes that play a major role in bacterial virulence. 1-MPNP competitively inhibits the activity of tyrosine phosphatases and prevents them from catalyzing the hydrolysis of polyphosphate substrates. This inhibition leads to an accumulation of polyphosphates in the bacterial cell membrane, which disrupts its permeability and leads to cell death.</p>

<p>3,3',4',5,5',8-Hexahydroxyflavone is a naturally occurring flavonoid, which is a type of polyphenolic compound. It is derived from various plant sources, including fruits, vegetables, and certain medicinal herbs. The compound is characterized by its chemical structure, which includes multiple hydroxyl groups, contributing to its biological activity.<br><br>The mode of action of 3,3',4',5,5',8-Hexahydroxyflavone involves its interaction with various cellular pathways and enzymes. Primarily, it is known for its antioxidant properties, where it scavenges free radicals and reactive oxygen species, thereby reducing oxidative stress. Additionally, it may exhibit anti-inflammatory effects by modulating signaling pathways involved in inflammation.<br><br>In terms of uses and applications, 3,3',4',5,5',8-Hexahydroxyflavone is primarily explored in scientific research focusing on its potential health benefits. Studies investigate its role in disease prevention, particularly conditions associated with oxidative stress and inflammation, such as cardiovascular diseases and neurodegenerative disorders. While it holds promise in these areas, further research is necessary to fully understand its mechanisms and therapeutic potential.</p>

<p>Applications N-Acetylethylene Urea-d4 (cas# 1189701-94-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Triethylborane reacted with 8-hydroxyquinoline to synthesize three 8--​hydroxyquinolato (q) boron compounds B(C2H5)​2q (1)​, BPh2q (2)​, and B(2-​naph)​2q (3).<br>References Wu, Q., et al.: Chem. Mater., 12, 79 (2000).<br></p>

<p>Applications Guanosine-5'-triphosphate disodium salt (CAS# 56001-37-7) is a nucleotide used in the preparation of photoreactive GTP affinity probes, and in inhibitors of eukaryotic initiation factor eIF-4E.<br>References George Cisar, E. A.; J. Am. Chem. Soc., 135, 4676 (2013); Ghosh, P.; et al.: Bioorg. Med. Chem. Lett., 16, 750 (2006).<br></p>