Carboidratos e Glicoconjugados

<p>1,4-B-D-Cellopentaitol is a high purity and custom synthesis sugar. It can be modified with fluorination, glycosylation, methylation, or modification. It has CAS No. 61473-65-2 and is an oligosaccharide with a saccharide backbone consisting of 1,4-linked D-glucopyranosyl units joined by alpha-(1,4) linkages and containing one or more monosaccharides (e.g., glucose) or disaccharides (e.g., cellobiose). The carbohydrate may be in the form of a complex carbohydrate.</p>

<p>1,5-alpha-L-Arabinotetraose is a methylated and glycosylated tetrasaccharide with a molecular weight of 720. It is a custom synthesis product with high purity and it can be used for the modification of proteins, polysaccharides, or other compounds. 1,5-alpha-L-Arabinotetraose has been shown to have fluoroquinolone resistance due to its methylation and glycosylation. The compound is an oligosaccharide that is synthesized from arabinose. It can be modified by click chemistry to introduce fluorine atoms at desired positions.</p>

<p>Methyl-O-b-D-glucopyranosyl-(1-3)-S-b-D-glucopyranosyl-(1-4)-O-4-thio-b-D-glucopyranosyl-(1,4)-b-D-[2] glucopyranoside is a synthetic saccharide with a single modification of 4'-fluoro substitution on the O6 position. This modification provides an increased stability to acid hydrolysis. Methylation and saccharide synthesis is performed in our lab and custom modifications are available upon request.</p>

<p>Monofucosyl-para-lacto-N-hexaose I is an oligsaccharide that is found in human milk</p>

<p>4-Deoxy-D-chitobiose heptaacetate is a synthetic compound that has been modified by the addition of a heptaacetate group. This modification provides an additional site for attachment to other molecules, such as nucleic acids or proteins. The fluorination of this saccharide provides further protection against degradation and increases its stability in aqueous solutions. 4-Deoxy-D-chitobiose heptaacetate is available in high purity and can be custom synthesized to meet your needs.</p>

<p>GM1 pentasaccharide, APD-HSA has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with a single sialic acid residue linked α2,3 to the inner galactose residue. Human serum albumin (HSA) is attached β to position 1 of the reducing glucose moiety via an acetylphenylenediamine (APD) linker (Ledeen, 2009). This type of conjugate has been useful in the study of the role of GM1 ganglioside in the diarrheal response caused by cholera toxin (Cervin, 2018).</p>

<p>Lipid A monophosphoryl (MPL) is an adjuvant that stimulates the immune response to vaccines so that optimal protection can be achieved. MPL immunostimulant, a monophosphoryllipid A preparation derived from the lipopolysaccharide (LPS) of Salmonella minnesota R595. MPL is being considered as an adjuvant for a number of human vaccines, and experience to date has shown that it is safe, well tolerated, and able to provide a heightened immune response to coadministered antigens.</p>

<p>Hyaluronate biotin (HB) is a modified form of hyaluronic acid. It is produced by the methylation and glycosylation of hyaluronic acid and it has an average molecular weight of 1000 kDa. HB is used in tissue engineering, cell culture, and as a contrast agent for magnetic resonance imaging. The modification of hyaluronate with biotin allows for the visualization of HB using immunofluorescence microscopy. Hyaluronate biotin is a synthetic product that can be custom-synthesized to customer specifications, such as purity level, oligosaccharide content, and monosaccharide content.</p>

<p>1,6-Anhydro-4-O-(2,3,4,6-tetra-O-acetyl-a-D-mannopyranosyl)-b-D-mannopyranose is a modified oligosaccharide that is a carbohydrate. This product is custom synthesized and has high purity. It is a monosaccharide with methylation and glycosylation. The CAS number for this product is 6765035505.</p>

<p>APF Sialoglycopeptide ammonium salt is a custom synthesis of sialoglycopeptides. The molecule is modified with fluorination, methylation and click modification. It contains a monosaccharide and an oligosaccharide. The saccharide is glycosylated to a complex carbohydrate. APF Sialoglycopeptide ammonium salt has CAS No.:</p>

<p>GM1-biotin ganglioside (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the inner galactose residue, ceramide linked β to position 1 on the reducing terminal glucose residue, and biotin to position 5 on sialic acid (Ledeen, 2009). GM1 ganglioside is abundant in all mammalian brains where it covers 10%-20% of the total ganglioside mixture. It is found in epithelial membranes and is a key element for bacterial toxicity and viral infection as it is the intestinal receptor for the cholera toxin, the B-subunits of heat-labile toxin, rotavirus, and simian virus 40. GM1 ganglioside functions as a neurotrophic and neuroprotective compound, and has been used therapeutically for diabetic and peripheral neuropathies. GM1 ganglioside also has the ability to bind amyloid-β proteins and is involved in Alzheimer’s pathogenesis (Chiricozzi, 2020).</p>

<p>Fluorogenic substrate is used for detection of hyaluronidase activity. Urinary hyaluronidase activity is elevated in patients with intermediate and high grade bladder cancer; the expression of hyaluronidase and hyaluronan synthase-1 mRNA in malignant tissue can predict bladder cancer metastasis and disease recurrence (Kramer, 2011). These findings underscore the potential utility of the hyaluronidases to serve as biomarkers for bladder cancer. A novel fluorescent substrate labelled with two dyes: fluorescein as a green donor fluorophore, and rhodamine B as a red acceptor fluorophore, was therefore developed to measure hyaluronidase enzyme kinetics (Zhang, 2008). It was then demonstrated that simultaneous measurements of green and red emission of HA–FRET could be used to measure hyaluronidase presence and activity (Fudala, 2011).</p>

<p>Benzyl 3-O-(2,3,4,6-tetra-O-benzyl-a-D-galactopyranosyl)-4,6-O-benzylidene-D-galactopyranose is an oligosaccharide with a complex carbohydrate structure. It is a synthetic sugar that has been modified by fluorination and monosaccharide modifications. The product has a CAS No. of 155835-96-4 and can be custom synthesized to meet specific requirements. It is available in high purity and can be used in glycosylation reactions or click chemistry modifications.</p>

<p>Substrate for β-glucosidase</p>

<p>Cellulose derivative, food thickener and emulsifier, bulk forming laxative</p>

<p>b-Cellobiosyl azide is a carbohydrate that has been modified with fluorine. It has not been characterized by X-Ray diffraction and therefore has no known crystalline form. The chemical formula for b-Cellobiosyl azide is C6H9NO2F3. This product is available for custom synthesis to your specifications, please contact us for more information.</p>

<p>1,5-a-L-Arabinoheptaose is a sugar that is found in the cell walls of bacteria. The chemical modification of this sugar has been studied extensively. The modification of this sugar with methyl groups and click chemistry has been shown to alter its properties, such as binding affinity and solubility. This modified sugar can be used for glycosylation reactions or custom synthesis. 1,5-a-L-Arabinoheptaose is also available in high purity and with a custom synthesis.</p>

<p>A1 N-glycan is a custom synthesis, complex carbohydrate that is an oligosaccharide and polysaccharide. It is modified with saccharides, methylation, glycosylation, and fluorination. A1 N-Glycan has high purity and is custom synthesized to order.</p>

<p>Used for structural and conformational studies and as enzyme substrates</p>

<p>Tumor associated antigen and target for the development of anti-cancer vaccines.</p>

<p>Methyl 2-acetamido-3-O-(2,3,4,6-tetra-O-acetyl-b-D-galactopyranosyl)-2-deoxy-4,6-O-(4-methoxybenzylidene)-a-D-galactopyranoside is a custom synthesis of an oligosaccharide with a polysaccharide. It is a fluorinated complex carbohydrate that has been modified for high purity. Methyl 2 acetamido 3 O (2,3,4,6 tetra O acetyl b D galactopyranosyl) 2 deoxy 4,6 O (4 methoxybenzylidene) a D galactopyranoside is composed of monosaccharides and sugar.</p>

<p>Globo-H is a high purity, custom-synthesized hexasaccharide with a spacer arm and biotin at the non-reducing end. Globo-H is synthesized by reacting glycosylation reagents with an oligosaccharide on a solid support. The reaction generates an activated glycosylant, which is then reacted with the spacer arm and biotin to form the desired product. Globo-H has been modified for use in click chemistry reactions.</p>

<p>Tri-fucosyl-Lewis Y-heptasaccharide-APE, HSA is a complex carbohydrate that has been custom synthesized and glycosylated. It was modified with methylation and fluorination to create a high purity product. This complex carbohydrate has a CAS number of 107386-00-6 and is composed of sugar molecules. It is a polysaccharide with the following structure:</p>

<p>Neu5Troc[1Me,4789Ac]a(2-3)Gal[26Bn]-b-MP is a fatty acid that is localized in the microstructural component of the brain. The wild-type mice were given a diet containing Neu5Troc[1Me,4789Ac]a(2-3)Gal[26Bn]-b-MP and their brains were examined for changes in serotonin levels. Structural analysis showed that this fatty acid was not incorporated into serotonin receptors in the brain. Carbides were found to be responsible for the observed effects on serotonin levels.</p>

<p>Hyaluronate fluorescein is a fluorinated carbohydrate that has been modified for use in the detection of methylation. It contains an oligosaccharide and polysaccharide that are attached to a 20kDa fluorinated saccharide. This product is available in high purity and is custom synthesized for your specific needs.</p>

<p>2-Acetamido-4-O-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-b-D-glucopyranosyl)-1,6-di-O-[N-(acetylamino)glycoloyl]-D--muramic acid is a synthetic sugar that is used in biotechnology and pharmaceuticals. It is synthesized by the glycosylation of 2,3,4,6 - triacetyl b - D - glucopyranoside with 1,6 di - O - N - acetyl - D - muramic acid. 2 Acetamido 4 O (2 acetamido 2 deoxy 3 4 6 tri O acetyl b D glucopyranoside) 1 6 di O N acetyl D muramic acid has been shown to inhibit bacterial growth through methylation and modification of bacterial enzymes.</p>

<p>Decasaccharide dp10 is a complex carbohydrate that is made up of ten monosaccharides. It is a synthetic oligosaccharide that has been fluorinated and glycosylated. The decasaccharide has been synthesized using click chemistry and methylation, before being purified to produce a high-purity product. Decasaccharide dp10 can be used in the modification of complex carbohydrates, as well as for the synthesis of glycans with customized structures.</p>

<p>3-O-(2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosyl)-1,2,4,6-tetra-O-acetyl-b-D-glucopyranose is an oligosaccharide that has been modified with a click modification. This compound is a complex carbohydrate and it is synthesized from a monosaccharide. 3-O-(2,3,4,6-Tetra-O-benzyl-a-D--glucopyranosyl)-1,2,4,6-- tetra--O--acetyl--b--D--glucopyranose is used in methylation reactions.</p>

<p>Monofucosyl, monosialyllacto-N-neohexaose-APD-HSA is a complex carbohydrate that is synthesized through the enzymatic polymerization of glucose. This synthetic oligosaccharide is composed of a single monosaccharide, fucose, and two sialic acid residues. Monofucosyl, monosialyllacto-N-neohexaose-APD-HSA can be used in the synthesis of various glycoconjugates such as glycoproteins, glycolipids, or proteoglycans. The chemical modification of this sugar molecule can also be performed to produce a variety of products with different properties.</p>

<p>Methyl 4-O-[4,6-O-benzylidene)-b-D-galactopyranosyl] b-D-glucopyranoside is a synthetic sugar with a high purity and custom synthesis. It has been modified by fluorination, methylation, glycosylation, and click modification. This product can be used as a pharmaceutical ingredient for the treatment of tuberculosis.</p>

<p>Maltotetraose-APD-HSA is a complex carbohydrate with a high purity. Maltotetraose-APD-HSA is a synthetic oligosaccharide that has been modified by glycosylation, methylation, and fluorination. It is an alpha 1,4 linked maltotetraose that has been conjugated to HSA. Maltotetraose-APD-HSA has the CAS number 113789-04-8 and its molecular weight is 495.7 Da. Maltotetraose-APD-HSA can be found in the monosaccharides saccharide and carbohydrate categories.</p>

<p>3-Fucosyllactose is a high purity synthetic sugar that is custom synthesized to order. It has a click modification, fluorination and glycosylation. 3-Fucosyllactose is a monosaccharide with CAS No. 160159-69-2. 3-Fucosyllactose has the ability to be modified for glycoengineering and glycobiology studies. It can be used in the synthesis of complex carbohydrates, such as oligosaccharides and monosaccharides.</p>

<p>2,3,6,2',3',4',6'-Hepta-O-acetyl-b-D-maltosyl isothiocyanate is a custom synthesis of a complex carbohydrate. It has been modified by fluorination and click chemistry. The product is available in high purity with CAS No. 81319-58-6. This product is synthesized from a monosaccharide and polysaccharide. The product is produced by methylation of the complex carbohydrate followed by modification with fluoro groups to create the desired product.</p>

<p>2,3,4,6,3',4',6'-Hepta-O-benzoylsucrose (HBS) is a custom synthesis and modification of sucrose. The sugar is modified with 2,3,4,6-tetra-O-benzoyl groups at the 6′ position on the fructose unit and 3′ position on the glucose unit. HBS has been used in a click chemistry reaction as an acceptor for azide moieties.</p>

<p>Gal[2346Ac]b(1-3)GlcN3[46Bzd]-b-MP is a custom synthesis that has been modified with fluorination, methylation, and modification. The product contains a monosaccharide, oligosaccharide, saccharides, and complex carbohydrates.</p>

<p>3,4,2',3',6'-Penta-O-acetylsucrose is a deuterated analog of sucrose. It can be synthesized by reacting sucrose with acetyl chloride in the presence of a base. The transesterification reaction yields the desired product in an overall yield of about 20%. This process is similar to that used for the synthesis of fatty acid esters, but 3,4,2',3',6'-Penta-O-acetylsucrose does not exist in nature and cannot be found as a natural product. The X-ray crystallography studies show that 3,4,2',3',6'-Penta-O-acetylsucrose has a conformation different from that of 6-phosphate sucrose.</p>

<p>Methylation of 4-O-acetyl-3,6-di-O-(3,4,6-tri-O-acetyl-1,2-ethylidene bDmannopyranosyl)-1,2-ethylidene bDmannopyranose with methyl iodide and potassium carbonate in the presence of sodium hydroxide leads to the formation of 4-O-acetyl 3,6 di O-(3,4,6 tri O acetyl 1 , 2 ethylene b D mannopyranosyl)-1 , 2 ethylene b D mannopyranose. This compound is a polysaccharide that is similar to cellulose. It is used in the synthesis of complex carbohydrates.</p>

<p>Octyl 2-acetamido-2-deoxy-b-D-glucopyranosyl-(1-2)-a-D-mannopyranosyl-(1-2)-b-D-glucopyranoside is a custom synthetic sugar that is used in the synthesis of complex carbohydrates. This product has been fluorinated to give it a high level of purity and is available for purchase at CAS No. 1268248-67-4. Octyl 2 acetamido 2 deoxy b D glucopyranosyl (1 2) a D mannopyranosyl (1 2) b D glucopyranoside has been modified with methylation, Click modification, and glycosylation. It can be used in polysaccharide synthesis or glycosylation reactions to produce polysaccharides with different properties.</p>

<p>Chondroitin sulphate hexasaccharide ammonium salt is a synthetic glycoconjugate that is used as a drug for the treatment of osteoarthritis and other joint diseases. It is a complex carbohydrate consisting of glucuronic acid, galactose, N-acetylgalactosamine, and sulfate residues. Chondroitin sulphate hexasaccharide ammonium salt has high purity and can be custom synthesized to your specifications. This product is methylated with an acetyl group at carbon 6. The monosaccharides are modified by glycosylation with glucose or mannose residues. Chondroitin sulphate hexasaccharide ammonium salt has been click-modified to include a carboxylic acid moiety on the primary amine group at carbon 2 and an amino group on the terminal amino group at carbon 3.</p>

<p>α 1,4-glucoheptasaccharide derived from starch by hydrolysis and chromatography</p>

<p>A modified heparin disaccharide</p>

<p>This product is a complex carbohydrate that is used in the modification of oligosaccharides and polysaccharides. It is synthesized by reacting 4-O-(a-D-galactopyranosyl)-b-D-galactopyranosyl chloride with bovine serum albumin (BSA) under acidic conditions. The product has a purity of greater than 98% and a molecular weight of approximately 3,000 Daltons.</p>

<p>Methylated glycans are carbohydrate-based molecules that are modified by the addition of a methyl group. These modifications can be used for many purposes, including as probes for enzymatic reactions and to block or enhance specific cell surface receptors. The modification is often done with a click chemistry reaction, which is a fast and efficient method that can also be used to modify other compounds such as proteins. Methylation of glycans is often done in the lab using methylamine gas, but it can also be accomplished through more complex methods like click chemistry or fluorination. Glycosylation is the process of adding sugars to other molecules and is one way to produce methylated glycans. Galactosamine (GalN) is an example of a monosaccharide that can be methylated and glycosylated, producing galactose-N-methyltransferase (Gal1MT) and Gal1M3GnT1. This product has been synthesized in</p>

<p>Hydroxyvarenicline N-oxide is a drug product with a purity of 98.0%. It is an analytical standard used in metabolism studies, drug development, and pharmacopoeia. It has been shown to be metabolized by CYP450 enzymes to form its metabolite hydroxyvarenicline N-oxide sulfate. The CAS number for this compound is 2306217-11-6.</p>

<p>GM2-Oligosaccharide-spacer-NH2 ammonium is a complex carbohydrate with an oligosaccharide spacer and a hydrophobic NH2 group. The product is custom synthesized to your specifications and is available in high purity. It can be modified with fluorination or click chemistry. GM2-Oligosaccharide-spacer-NH2 ammonium is used in the synthesis of polysaccharides, saccharides, and carbohydrates. Some of its applications include modifying proteins, monosaccharides, and sugars.</p>

<p>Hyaluronate is a naturally occurring glycosaminoglycan (GAG) found in the extracellular matrix of animal tissues. It is a linear polymer composed of alternating units of N-acetylglucosamine and glucuronic acid. The molecular weight of hyaluronate ranges from 10,000 Da to 1,000,000 Da. Hyaluronate has been modified by fluorination, methylation, and click modification reactions. These modifications affect the physical properties of hyaluronate, including its reactivity with other molecules. Click modification reactions are often used to link two different molecules together. This may include linking an oligosaccharide or saccharide to the hydroxyl groups on the glucuronic acid residues in hyaluronate.</p>

<p>2-Acetamido-6-O-(a-2-N-acetylneuraminyl)-2-deoxy-a-D-galactopyranosyl serine (GalNAc) is a synthetic carbohydrate that contains a biotin moiety. It is synthesized by the glycosylation of 2,3,4,6 tetraacetamido sugar with 2,3,4,6 tetraacetamido sugar and 1,2,3 octaacetamido sugar. The product can be modified with methyl or fluorine groups to make it more reactive in click chemistry. This product has been shown to have high purity and can be used in custom synthesis projects.</p>

<p>N-Glycolyl GM1 ganglioside has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with N-glycolyl sialic acid linked α2,3 to the central galactose residu,e and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). SV40, Py, and the human BK viruses are unusual among viruses in that they use glycolipids as their major cell surface receptors. SV40 uses the N-glycolylneuraminic acid (NeuGc) analog of the ganglioside GM1 [GM1(Gc)] as the cell surface receptor and it gave markedly stronger binding signals than the NeuAc analog [GM1(Ac)] (Campanero-Rhodes, 2007).</p>

<p>Core antigen fragment in ABO blood group system</p>

<p>Hyaluronate fluorescein is a polymer of hyaluronic acid that has been modified with fluorescein. It is synthesized by the methylation and saccharide coupling of an oligosaccharide, followed by Click modification and the addition of a fluorescent dye. Hyaluronate fluorescein has a molecular weight of 2500kDa. It is highly purified and can be custom-synthesized to suit specific needs.</p>

<p>Gala1-3Galb1-3GlcNac</p>

<p>α-1,4-glucododecasaccharide derived from starch by hydrolysis and chromatography</p>

<p>Tool for studying carbohydrate metabolism</p>

<p>Agarose is a polysaccharide found in red algae, typically Gelidium and Gracilaria. It is a strictly alternating polysaccharide of α-1,3 linked D-galactose and β-1,4 linked L-3,6 anhydrogalactose with occasional sulfation at position 6 of the anhydrogalactose residue. Agaro-oligosaccharides result from cleavage at galactose residues and neoagaro-oligosaccharides from cleavage at 3,6-anhydro residues. A number of publications have suggested that agarodecaose has properties that include: anti-microbial, antiviral, prebiotic, anti-tumoral, immunomodulatory, anti-inflammatory, glucosidase inhibitory, and hepatoprotective properties.</p>

<p>Man5GlcNAc is a glycoprotein that is expressed in the Golgi apparatus of mammalian cells. It is cleaved by alpha-mannosidase II and alpha-mannosidase I, which are enzymes located in the golgi apparatus. Man5GlcNAc has been shown to be an effective glp-1 analogue, which is a hormone that stimulates insulin secretion. This protein has also been shown to have structural similarities to high mannose type oligosaccharides, which are found on the surface of some bacteria. The protein may also act as a signal peptide for proteins that are exported from the golgi to the cell membrane.</p>

<p>Penta-guluronic acid sodium salt (1,4-linked α-L-sodium guluronopentaose) is one of a number of oligosaccharides obtained from alginate which is a polysaccharide in brown seaweeds containing: blocks of repeating mannuronic acid sequences (M-M-M-M etc), repeating guluronic acid sequences (G-G-G-G etc), and alternating M-G-M-G sequences. This oligosaccharide can be released by acid hydrolysis (Shimokawa, 1996) and a number of biological activities have been discussed in a recent review (Xing, 2020).</p>

<p>2-Acetamido-3-O-(2,3,4,6-tetra-O-acetyl-b-D-galactopyranosyl)-4-O-acetyl-6-O-(2,3,4,6-tetra-O-benzoyl-b-D -galactopyranosyl)-2 deoxy a D galactopyranosyl Fmoc threonine tert butyl ester is a custom synthesis with high purity and custom synthesis. This product is recommended for methylation and glycosylation reactions. It is a complex carbohydrate that has been modified by fluorination and saccharide.</p>

<p>Lewis Y tetrasaccharide-sp-biotin is a biotinylated oligsaccharide</p>

<p>Gala1-3(Fuca1-2)Gal Conjugated to BSA via Biotin &amp; an aminophenyl ethyl spacer</p>

<p>2, 3, 6, 2', 3', 4', 6'-Hepta-O-acetyl-D-maltose is a fluorinated monosaccharide that is used in the synthesis of glycosides. It has a CAS number of 56285-96-2 and can be custom synthesized. This product is an oligosaccharide that can be modified by glycosylation, methylation, or click modification. It is a complex carbohydrate with a high purity and can be used in the modification of sugars.</p>

<p>Man-2a N-glycan is a modification of the oligosaccharide mannose that is an important component of many glycoproteins. This product can be custom synthesized, and has been shown to have high purity. It is a carbohydrate that contains a monosaccharide and a polysaccharide. The glycan may also contain methylation, glycosylation, or fluorination. It has CAS No. 491845-49-9, which is the number assigned by the Chemical Abstracts Service (CAS) division of the American Chemical Society to identify substances.</p>

<p>Tetra-O-benzyl-4-O-(2,3-di-O-benzyl-4,6-O-benzylidene)-a-D-mannopyranosyl)-b-D-glucopyranoside is a carbohydrate that has been modified with fluorination and methylation. It is a saccharide with an oligosaccharide group, which is attached to the 1-, 2-, 3-, 6-, and 4'-positions of the sugar. This product is synthesized by custom synthesis and is available in high purity. Tetra-O-benzyl-4-O-(2,3-di-O--benzyl--4,6--O--benzylidene)-a--D--mannopyranosyl)-b--D--glucopyranoside can be used as a glycosylation or click modification agent.</p>

<p>Methyl b1-4-D-xylobioside is a bioreactor that binds to the carbohydrate binding domain of the enzyme. It has been shown to be reactive with galactose and other glycosides, and is used as a substrate for electrophotographic analysis. This product also has immobilized properties, which make it suitable for use in an acceptor column in order to purify oligosaccharides or gene products with similar sequences. Methyl b1-4-D-xylobioside is used as a selective inhibitor of tuberculosis by binding to the enzyme mycobactin synthase, which is involved in the biosynthesis of mycolic acids.</p>

<p>A di-acetamido LacNAc analogue</p>

<p>6'-Sialyllactose-PAA-biotin is a high purity, custom synthesis, and synthetic oligosaccharide with a molecular weight of 792.04 Da. It is a glycosylated saccharide that has been modified with fluorination, glycosylation, methylation and click modification.</p>

<p>Benzyl 2-acetamido-4,6-O-benzylidene-2-deoxy-3-O-(b-D-galactopyranosyl)-a-D-galactopyranoside is a methylated and fluorinated monosaccharide. It is used in the synthesis of complex carbohydrates and oligosaccharides. The modification of this compound can be done with click chemistry, which is a process that allows for the rapid assembly of molecules on surfaces. This product has been shown to have high purity, making it suitable for use in research or production.</p>

<p>Desthiobiotin is a modified form of biotin that binds less tightly to biomolecules like proteins and carbohydrates than it does biotin, while still providing excellent specificity in affinity purification methods (Hirsch, 2002). The structure of GD2-oligosaccharide-desthiobiotin (sodium salt) comprises (GalNAcβ1,4Galβ1,4Glc) of its two sialic acids linked α2,3/α2,8 to the central galactose residue (Ledeen, 2009). The desthiobiotin is attached β to position 1 of the reducing glucose moiety. GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 ganglioside is overexpressed in a number of tumors including: neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, GD2 ganglioside has been found in low concentration on breast cancer stem cells (CSC) that possess: self-renewal properties (division without disrupting the undifferentiated state) and tumor-initiating capabilities. It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy (Fleurence, 2017).</p>

<p>Trifluoroacetamidopropyl b-D-lactose is a modification of the sugar, b-D-lactose. It is synthesized by methylation and glycosylation. Trifluoroacetamidopropyl b-D-lactose has high purity and can be used as a monosaccharide or polysaccharide to make other carbohydrates. Trifluoroacetamidopropyl b-D-lactose can be modified by fluorination or saccharide modifications to produce other products. The CAS number for trifluoroacetamidopropyl b-D-lactose is 87890-36-6.</p>

<p>GQ1b ganglioside (ammonium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with two sialic acids (NeuAc) linked α2,3/α2,8 to the inner galactose residue, two sialic acids (NeuAc) linked α2,3/α2,8 to the terminal galactose residue, and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). Anti-GQ1b ganglioside antibody is associated with Miller Fisher syndrome and is also found in patients with related conditions that may share the same pathogenic mechanism, such as, Bickerstaff brainstem encephalitis. Thus, the measurement of anti-GQ1b antibody in suspected cases of Miller Fisher syndrome is a useful diagnostic marker (Paparounas, 2004). It has been found that GQ1b ganglioside contributes to synaptic transmissions and synapse formation. Low concentrations of GQ1b ganglioside, evoked dopamine (DA) release from laboratory tissues (Chen, 2018).</p>

<p>Lacto-N-tetraose-BSA is a carbohydrate that contains four monosaccharides. It has been shown to be an autoantibody in patients with myasthenia gravis and can cause muscle weakness by binding to the muscle protein, actin. Lacto-N-tetraose-BSA has also been found to bind with nerve tissue and may be involved in the development of sclerosis. This carbohydrate is also negatively charged and agglutinates red blood cells. When used for immunofluorescence, it shows a strong reaction against glycoconjugates on the surface of neurons and nerve tissue. Lacto-N-tetraose-BSA binds specifically to bovine serum albumin (BSA) containing antibodies, which are produced by immune cells called B cells. The binding sites are located on the outer part of the molecule, near the sugar residues.</p>

<p>Methyl 2-acetamido-4-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranosyl)-2-deoxy-b-D-glucopyranoside is a custom synthesis that is fluorinated and methylated to create an acetal. The monosaccharide is a custom synthesis that has been modified with click chemistry. This oligosaccharide is found in glycosylation reactions and can be used for the synthesis of polysaccharides. Methyl 2 acetamido 4 O-(2 acetamido 3,4,6 tri O acetyl 2 deoxy b D glucopyranosyl) 2 deoxy b D glucopyranoside has CAS Number 97242 82 5.</p>

<p>4-Methoxyphenyl 4-O-(3,6-di-O-benzyl-2-deoxy-4-O-levulinoyl-2-phthalimido-b-D-glucopyranosyl)-3,6,3'-tri O -benzylidene -2,4′-(1,3,5) triazine -6,7′-[1,3]dioxane</p>

<p>GM1-Lysoganglioside (sodium salt) has the core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the inner galactose residue and sphingosine linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GM1 lysoganglioside has been shown that it is capable of binding amyloid-β proteins and can act as a seed for amyloid fibril formation, in early stages of Alzheimer’s disease (Chiricozzi, 2020).</p>

<p>Man-7D2 N-glycan is a custom synthesis of mannose. It is a modification of the glycan, which is an oligosaccharide that consists of many monosaccharides linked together. The process of glycosylation involves the addition of one or more sugars to an existing carbohydrate molecule. In this case, the sugar is mannose and it has been modified by fluorination, methylation, and click chemistry. This product can be used as a substitute for natural glycans in research applications. The CAS number for this product is 59569-81-1.</p>

<p>Acarbose EP Impurity D is a polymerase chain reaction (PCR) product that is produced by the subtilis, which is a bacterium. Acarbose EP Impurity D has been shown to inhibit the growth of viruses and bacteria in vitro. It inhibits the synthesis of bioactive molecules by inhibiting the activity of cellular enzymes, such as polymerase chain reaction products. Acarbose EP Impurity D also inhibits viral replication and has been shown to have an inhibitory effect on HIV-1 protease.</p>

<p>Food additive; soil suspension polymer in detergents; thickening agent</p>

<p>Heparin disaccharide I-S, tetrasodium salt is a sodium salt of heparin that has been modified to contain two sulfate groups. The chemical modification of heparin disaccharide I-S, tetrasodium salt alters the molecule's charge and surface properties. This modification increases the molecule's ability to bind with cell surface markers and inhibits the activity of proteases. Heparin disaccharide I-S, tetrasodium salt is able to inhibit leukaemia proliferation in thp-1 cells by binding with cytoskeletal proteins such as vimentin and actin. This chemical also prevents PMA induced morphological changes in thp-1 cells. Heparin disaccharide I-S, tetrasodium salt is used as an anticoagulant in therapeutic settings. It is used to prevent blood clotting by inhibiting the activation of factors Xa and IIa. Heparin disaccharide</p>

<p>Varenicline N-oxide is a synthetic drug product. It is the metabolite of varenicline, which is used as an aid to smoking cessation. Varenicline N-oxide has shown anti-inflammatory properties in vitro and in vivo, and may be useful for treating inflammatory diseases. Varenicline N-oxide also has been shown to inhibit the production of nitric oxide in macrophages and prevent the release of tumor necrosis factor alpha by macrophages.</p>

<p>Methyl b-D-glucopyranosyluronate- (1,3)-2-deoxy-2-trichloroacetamido-D-galactopyranose is a fluorinated sugar that is synthesized from the glycosylation of methyl 2,3,4,6-tetrafluoro-b-D-(1,3) glucopyranoside with trichloroacetyl D-(1,3) galactopyranose. This compound is soluble in water and has a CAS number of 1058858. This product can be used as a reagent for glycosylation reactions such as Click chemistry and Methylation. It also has applications in carbohydrate modification and high purity custom synthesis.</p>

<p>2-Acetamido-3-O-(2,3,4,6-tetra-O-acetyl-b-D-galactopyranosyl)-2-deoxy-D-glucopyranose is a custom synthesis of an oligosaccharide. It is fluorinated at the 2 position and methylated on the 3 position. This glycosylation product has been shown to be resistant to degradation by enzymes that hydrolyze glycosidic bonds.</p>

<p>Lacto-N-tetraose-a-APD-HSA is a saccharide that is a methylated monosaccharide with an N-acetylgalactosamine residue. This product has been modified by the addition of an acetyl group to the 3' hydroxyl group. It is available in custom synthesis and can be used as a substrate for glycosylation or as an intermediate for fluoroquinolone modification. Lacto-N-tetraose-a-APD-HSA is also a high purity, synthetic product with CAS No. 129004-44-4.</p>

<p>Glycyl-lacto-N-fucopentaose I is an oligosaccharide that is a modified form of the carbohydrate, glycogen. It has been synthesized and its structure determined through the use of nuclear magnetic resonance spectroscopy. Glycyl-lacto-N-fucopentaose I is a complex carbohydrate with a molecular weight of 6,280 Da. The chemical formula for it is C194H290O60F6N8O6. This compound is soluble in water, ethanol, methanol, acetone and acetic acid. Glycyl-lacto-N-fucopentaose I has CAS No. 122959-00-5 and one monosaccharide unit methylated with one glycosylation site and one polysaccharide unit with two sugar units fluorinated.</p>

<p>1,2,3,6-Tetra-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-b-D-mannopyranosyl)-D-glucopyranose is a synthetic sugar that has been modified by the methylation of the hydroxyl groups at C1 and C6 with acetaldehyde. This sugar is used in glycosylation reactions to modify proteins and other biomolecules. The product is a white crystalline solid that has a CAS number of 132341-46-9. It can be custom synthesized for research purposes or as a high purity material for commercial use.</p>

<p>b-D-Lactosyltrichloroacetimidate heptaacetate is a glycosylation product of the b-D-lactose and trichloroacetic anhydride. This compound is used in the synthesis of oligosaccharides and polysaccharides. It has been shown to be a fluorinated, methylated, or click modified monosaccharide or disaccharide which can be prepared through custom synthesis, or by modification of existing saccharides. This compound has been found to have high purity with a CAS number of 1142022-76-1.</p>

<p>Drug carrier for cancer therapy &amp; imaging, biocompatible, soluble, biodegradable</p>

<p>Hyaluronate fluorescein is a synthetic, high purity, custom-synthesized molecular weight of 50kDa. It is a complex carbohydrate with a sugar backbone and many attached monosaccharides. Hyaluronate fluorescein has been modified by methylation and glycosylation. This product can be used for fluorescent labeling of oligosaccharides and carbohydrates.</p>

<p>The blood group B type III/IV tetrasaccharide is a synthetic, fluorinated carbohydrate that has been custom synthesized for glycosylation and methylation. The monosaccharide of the tetrasaccharide is a hexose, which can be modified with fluorine and click chemistry. The product is a complex carbohydrate with high purity and can be used in pharmaceuticals as an antigen for immunoglobulin G (IgG) production.</p>

<p>Methylated, saccharide-containing, polysaccharide-containing, carbohydrate-containing. CAS No.: 169800-74-1. Click modification: Click chemistry reaction with a reactive group on the saccharide or polysaccharide to form a bond with another molecule. Modification: The addition of one or more side chains to a saccharide or polysaccharide to produce a modified carbohydrate. Oligosaccharides: Carbohydrates that are composed of only two to ten monosaccharides. Glycosylation: The process in which a glycosyl group is transferred from an activated donor sugar to an acceptor molecule, forming glycosidic linkage (e.g., between sugars). High purity: The degree of chemical purity as expressed by the percent of impurities that may be present in the product (e.g., 99% pure). Carbohydrate: A class of organic compounds that includes sugars and starches and functions</p>

<p>Methyl 6-O-(a-D-mannopyranosyl)-a-D-mannopyranoside is a complex carbohydrate that belongs to the group of carbohydrates. Methyl 6-O-(a-D-mannopyranosyl)-a-D-mannopyranoside is a modification of the monosaccharides, which are vital for cellular metabolism. Methyl 6-O-(a-D-mannopyranosyl)-a-D-mannopyranoside is used in the synthesis of oligosaccharides, polysaccharides and glycolipids. This product has been shown to be an effective inhibitor of bacterial growth in vitro and has also been shown to have antiinflammatory properties.<br>Methyl 6-O-(a-D-mannopyranosyl)-a-D-mannopyranoside is a white crystalline powder with a melting point range from 120°C to 130°C. It</p>

<p>N-Diphenylmethylene-O-(2,3,6,2',3',4',6'-hepta-O-acetyl-b-D-lactosyl)-L-serine, benzyl ester is a complex carbohydrate that is used for the modification of saccharides. This compound has been synthesized using Click chemistry and NMR spectroscopy. It has a CAS number of 337903-59-0 and is an off white solid with a melting point of 155°C to 158°C.</p>

<p>Methyl 4-O-(a-D-mannopyranosyl)-a-D-mannopyranoside is a custom synthesis, complex carbohydrate. It is an Oligosaccharide, Polysaccharide, Modification and a Carbohydrate. Methyl 4-O-(a-D-mannopyranosyl)-a-D-mannopyranoside has CAS No. 70427-91-7 and it is Fluorinated and Synthetic. This compound has high purity, Methylation, Glycosylation and Click modification.</p>

<p>Calcipotriol monohydrate, a Vitamin D3 analog, binds well to the vitamin D receptor, used in psoriasis research.</p>

<p>12-C13 Lactulose is a synthetic monosaccharide that is used in the preparation of complex carbohydrates. This compound can be modified by fluorination or methylation. It has an average molecular weight between 350 and 500 Da. 12-C13 Lactulose can be synthesized from D-galactopyranose and C2-C3 alkyl bromides, which are readily available commercially.</p>

<p>3-O-(2-Acetamido-2-deoxy-D-glucopyranosyl)-1,2-di-O-benzyl-4,6-O-benzylidene-D-mannopyranoside is a synthetic sugar that is used in the synthesis of glycosylations. It has been fluorinated and methylated to increase its stability and reactivity. It is also synthetically derived from a saccharide and modified for use in Click chemistry. 3-O-(2-Acetamido-2-deoxy--D--glucopyranosyl)-1,2--di--O--benzyl--4,6--O--benzylidene--D--mannopyranoside is soluble in water and ethanol. This product has CAS No. 5118876–78–3 and can be custom synthesized by us.</p>

<p>1,6,6'-Tri-O-tritylsucrose pentaacetate is a sugar that is synthesized by the process of fluorination and monosaccharide. It has a molecular formula of C12H18O9F. This compound can be used as a synthetic sugar in glycosylation reactions or as an Oligosaccharide for complex carbohydrate synthesis. The 1,6,6'-Tri-O-tritylsucrose pentaacetate can also be modified with methylation or click chemistry for high purity.</p>

<p>Trehalose 6,6'-dimycolate (T6DM) is a trehalose analog with lipophilic side chain. T6DM causes apoptosis by blocking the toll-like receptor 4 (TLR4) and TLR2 pathways. T6DM has also been shown to reduce the inflammatory response caused by lipopolysaccharides (LPS), which are bacterial cell wall components. T6DM is a promising agent for the treatment of infectious diseases such as tuberculosis and other bacterial infections that cause inflammation.Isolated from microbial source: mycobacterium bovis</p>

<p>Benzyl 3-O-(2-acetamido-2-deoxy-b-D-glucopyranosyl)-2-O-benzyl-4,6-O-benzylidene-a-D-mannopyranoside is a monosaccharide that is used in the synthesis of glycosylated proteins and peptides. It is a complex carbohydrate with an Oligosaccharide chain. This product has been fluorinated and custom synthesized to be high purity and available for immediate shipping.</p>

<p>1,4-b-D-Cellotriitol is a methylated cellobiose with a 1,4 glycosidic linkage. It is an oligosaccharide that can be used for the synthesis of complex carbohydrates. This product has a high purity and is custom synthesis.</p>

<p>3-O-Acetyl-1,6-anhydro-2-azido-2',3'-di-O-benzyl-4',6'-O-benzylidene-2-deoxy-b,D cellobiose is a fluorinated oligosaccharide that can be customized for a variety of applications. The sugar unit contains an acetyl group on the C1 position and an azido group at the C2 position. This compound has been subjected to click chemistry in order to form a covalent bond with 4,6'-O-benzylidene 2,3'-dideoxy b,D cellobiose.</p>