Cetonas e Derivados
As cetonas são compostos orgânicos que contêm um grupo carbonilo (C=O) ligado a dois átomos de carbono, formando uma estrutura onde o grupo carbonilo é flanqueado por grupos alquila ou arila. Na farmacologia, as cetonas são utilizadas na formulação de APIs devido à sua capacidade de melhorar a solubilidade e a estabilidade dos princípios ativos. Algumas cetonas possuem propriedades anti-inflamatórias, analgésicas e antimicrobianas. Os derivados de cetonas incluem compostos nos quais o grupo carbonilo é modificado, como os enóis, que têm aplicações na síntese de fármacos e como intermediários químicos na produção de outros compostos bioativos. Os derivados de cetonas são utilizados no desenvolvimento de novos medicamentos, incluindo aqueles para o tratamento de doenças neurodegenerativas, distúrbios metabólicos e certos tipos de câncer, devido aos seus efeitos específicos sobre enzimas e processos celulares.
Foram encontrados 2393 produtos de "Cetonas e Derivados"
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4′-Chloro-3′-(trifluoromethoxy)acetophenone
CAS:Fórmula:C9H6ClF3O2Cor e Forma:SolidPeso molecular:238.591,1′-(2-Hydroxy-5-methyl-1,3-phenylene)diethanone
CAS:Fórmula:C11H12O3Pureza:95.0%Peso molecular:192.2144-Chloro-3-(trifluoromethyl)acetophenone
CAS:Fórmula:C9H6ClF3OPureza:98%Cor e Forma:SolidPeso molecular:222.59(S)-(+)-Ibuprofen Propylene Glycol Ester
CAS:Produto ControladoFórmula:C16H24O3Cor e Forma:NeatPeso molecular:264.362,2-Dimethoxy-2-phenylacetophenone
CAS:<p>Applications 2,2-Dimethoxy-2-phenylacetophenone (cas# 24650-42-8) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C16H16O3Cor e Forma:White PowderPeso molecular:256.301-(3,4-Dimethylphenyl)ethanol
CAS:Produto Controlado<p>Applications 1-(3,4-Dimethylphenyl)ethanol is an intermediate in the production of Medetomidine (M203250), α2-Adrenergic agonist. Sedative; analgesic.<br>References Kagechika, H., et al.: J. Med. Chem., 32, 1098 (1989), ; Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987),<br></p>Fórmula:C10H14OCor e Forma:NeatPeso molecular:150.22rac-2’,4’-Dimethyl Ketoprofen
CAS:Produto Controlado<p>Applications rac-2’,4’-Dimethyl Ketoprofen is an impurity of Ketoprofen (K200800), an anti-inflammatory and analgesic agent.<br>References Ueno, K., et al.: J. Med. Chem., 19, 941 (1976); Liversidge, G.G., Anal. Profiles Drug Subs., 10, 443 (1981); Jamali, F., et al.: Clin. Pharmacokinet., 19, 197 (1990)<br></p>Fórmula:C18H18O3Cor e Forma:NeatPeso molecular:282.333-(Cyanomethyl)benzoic Acid
CAS:Produto Controlado<p>Impurity Ketoprofen EP Impurity H<br>Applications 3-(Cyanomethyl)benzoic Acid (Ketoprofen EP Impurity H) is a reagent used in the synthesis of various pharmaceutically important compounds, such as its use in the synthesis of neprilysin inhibitors.<br>References Solomon, S.D., et al.: Lancet., 380 1387 (2012); Dadd, M.R., et al.: Enzyme. Microb. Tehcnol., 29, 20 (2001);<br></p>Fórmula:C9H7NO2Cor e Forma:NeatPeso molecular:161.16R-(-)-Norapomorphine Hydrochloride
CAS:Produto Controlado<p>Applications An Apomorphine derivative as inhibitor of amyloid-β (Aβ) fibril formation and their use in amyloidosis based disease.<br>References Howlett, D., et al.: Biochem. J., 340, 283 (1999), Kuner, P., et al.: J. Biol. Chem., 275, 1673 (2000), Ono, K., et al.: J. Neurosci. Res., 75, 742 (2004),<br></p>Fórmula:C16H15NO2•HClPureza:>90%Cor e Forma:NeatPeso molecular:253.3036463-(6-Methoxy-2-naphthalenyl)-5-methylcyclohexanone (Impurity)
CAS:Fórmula:C18H20O2Cor e Forma:NeatPeso molecular:268.35N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-N-methylnitrous amide
CAS:Produto ControladoFórmula:C12H14N4O2Cor e Forma:NeatPeso molecular:246.27(-)-N-Desmethyl Tramadol
CAS:Produto Controlado<p>Applications An optically active metabolite of Tramadol.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lintz, V.W., et al.: Arzneim.-Forsch./Drug Res., 31, II, 11, 1932 (1981)<br></p>Fórmula:C15H23NO2Cor e Forma:NeatPeso molecular:249.3516,17-Dehydro Capsaicin
CAS:Produto Controlado<p>Stability Light Sensitive<br>Applications A dehydrogenated metabolite of Capsaicin (C175680).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Glinsukon, T., et al.: Toxicon, 18, 215 (1980), Obach, R., et al.: Drug Metab. Dispos., 29, 1599 (2001), Reilly, C., et al.: Toxicol. Sci., 73, 170 (2003),<br></p>Fórmula:C18H25NO3Cor e Forma:Off-White To BrownPeso molecular:303.43-Methoxy Acetaminophen-d3
CAS:Produto Controlado<p>Applications 3-Methoxy Acetaminophen-d3 is deuterium labeled 3-Methoxy Acetaminophen (M226050). 3-Methoxy Acetaminophen is a metabolite of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)<br></p>Fórmula:C92H3H8NO3Cor e Forma:NeatPeso molecular:184.207Ketoprofen-13CD3 Methyl Ester
CAS:Produto Controlado<p>Applications An intermediate for the synthesis of Labelled Ketoprofen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Derewenda, Z., et al.: J. Mol. Biol., 227, 818 (1992), Grochulski, P., et al.: J. Biol. Chem., 268, 12843 (1993).<br></p>Fórmula:C1613CH13D3O3Cor e Forma:NeatPeso molecular:272.324'-Isobutyl-2,2-dibromopropiophenone
CAS:Produto Controlado<p>Applications Intermediate in the synthesis of Ibuprofen.<br></p>Fórmula:C13H16Br2OCor e Forma:NeatPeso molecular:348.07Trimebutine EP Impurity E-Nitroso
Produto ControladoFórmula:C21H26N2O6Cor e Forma:NeatPeso molecular:402.4411-(2,5-Dimethylphenyl)ethanol
CAS:Produto Controlado<p>Applications 1-(2,5-Dimethylphenyl)ethanol can be used as a reagent in reactions or as a aroma compound<br>References Zhou, J., et al.: Yuanyi Xuebao., 37, 1621-1628 (2010)<br></p>Fórmula:C10H14OCor e Forma:NeatPeso molecular:150.22Trimebutine-d9 Maleate Salt
CAS:Produto Controlado<p>Applications Trimebutine-d9 Maleate Salt, is the labeled analogue of Trimebutine Maleate Salt (T795605), acting as an opioid receptor agonist. Antispasmodic.<br>References Delvaux, M., et al.: J. Int. Med. Res., 25, 225 (1997), Lavit, M., et al.: Arzneim.-Forsch., 50, 640 (2000),<br></p>Fórmula:C22H20D9NO5·C4H4O4Cor e Forma:NeatPeso molecular:512.6D 13223-d4 (Flupirtine Metabolite)
CAS:Produto Controlado<p>Applications The major active labelled metabolite of Flupirtine in human plasma. A potassium channel opener<br>References Niebch, G., et al.: Arzneim.-Forsch., 42, 1343 (1992), Friedel, H., et al.: Drugs, 45, 548 (1993), Fu, I., et al.: J. Pharm. Biomed. Anal., 18, 347 (1998),<br></p>Fórmula:C14H12D4ClFN4OCor e Forma:NeatPeso molecular:314.78(S)-(+)-Ibuprofen 2-(Benzyloxy)propan-1-yl Ester
Produto Controlado<p>Applications (S)-(+)-Ibuprofen 2-(Benzyloxy)propan-1-yl Ester is an intermediate in the synthesis of (S)-(+)-Ibuprofen Propylene Glycol Ester (I140100), a derivative of (S)-(+)-Ibuprofen (I140010), a nonsteroidal anti-inflammatory drug (NSAID).<br>References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986), Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993), Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998),<br></p>Fórmula:C23H30O3Cor e Forma:NeatPeso molecular:354.4836,6'-Dimethoxy-2,2'-binaphthalene
CAS:Produto Controlado<p>Applications 6,6'-Dimethoxy-2,2'-binaphthalene, can be used for the synthesis of novel classes of non-steroidal substrate mimetics, as inhibitors of human CYP17. It is also an impurity of Nabumetone (N200500), a non-steroidal anti-inflammatory drug, acting as anti-inflammatory agent.<br>References Kumpulainen, H., et al.: J. Med. Chem., 49, 1207 (2006); Pinto-Bazurco, M. A. E., et al.: Bioorg. Med. Chem. Lett., 18, 267 (2008);<br></p>Fórmula:C22H18O2Cor e Forma:NeatPeso molecular:314.38(±)-Carisoprodol-d7 (iso-propyl-d7)
CAS:Produto Controlado<p>Applications (±)-Carisoprodol-d7 (iso-propyl-d7) (CAS# 1218911-01-3) is a useful isotopically labeled research compound. As a deuterated drug analog, this compound can be used for inter-patient variability.<br>References Gant, T., et.al., U.S. Pat. Appl. Publ., 28,(2010);<br></p>Fórmula:C12H17D7N2O4Cor e Forma:NeatPeso molecular:267.38Nabumetone-d3
CAS:Produto Controlado<p>Applications Labelled Nabumetone. Anti-inflammatory. Antibacterial.<br>References Kumpulainen, H., et al.: J. Med. Chem., 49, 1207 (2006),<br></p>Fórmula:C152H3H13O2Cor e Forma:NeatPeso molecular:231.30(+)-N,O-Didesmethyl Tramadol
CAS:Produto Controlado<p>Applications An optically active metabolite of Tramadol.<br>References Garrido, M., et al.: J. Pharmacol. Exp. Ther., 305, 710 (2003), Pedersen, R., et al.: Eur. J. Clin. Pharmacol., 62, 513 (2006),<br></p>Fórmula:C14H21NO2Cor e Forma:NeatPeso molecular:235.324-Morpholineethanol-d4
CAS:Produto Controlado<p>Applications Labelled analogue 4-(2-Hydroxyethyl)morpholine, a morphiline derivative used in the preparation of ester prodrugs of naproxen. 4-(2-Hydroxyethyl)morpholine was also shown to induce repair in rat hepatocyte primary culture/DNA.<br></p>Fórmula:C6H9D4NO2Cor e Forma:NeatPeso molecular:135.205-(6-Methoxy-2-naphthalenyl)-3-methyl-2-cyclohexen-1-one
CAS:Produto ControladoFórmula:C18H18O2Cor e Forma:NeatPeso molecular:266.33Methyl 5-Methoxy-2-methylindole-3-acetate
CAS:Produto Controlado<p>Applications Intermediate in the preparation of Indomethacin<br>References Kalgutkar, A.S., et al.: Bioorg. Med. Chem., 13, 6810 (2005),<br></p>Fórmula:C13H15NO3Cor e Forma:NeatPeso molecular:233.26L-Propoxyphene-d5 HCl (propionyl-d5)
CAS:Produto Controlado<p>Applications L-Propoxyphene-d5 Hydrochloride is the isotope labelled analog and L-isomer of Propoxyphene Hydrochloride (P831500); a controlled substance (opiate) and analgesic (narcotic). The α-DL-and D-diastereoisomers possess marked analgesic activity in contrast to the β-diastereoisomers which are substantially inactive. Oral administration of L-Propoxyphene Hydrochloride enhances the analgesic activity of D-Propoxyphene Hydrochloride.<br>References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971); McEwan, B., et al.: Anal. Profiles Drug Subs., 1, 301 (1972); Murphy, P.J., et al.: J. Pharmacol. Exp. Ther., 199, 415 (1976)<br></p>Fórmula:C22H25D5ClNO2Cor e Forma:NeatPeso molecular:380.963,4-Methylenedioxy Propiophenone
CAS:Produto Controlado<p>Applications Intermediate in the production of Isosafrole and Ethylone.<br>References Katoch-Rouse, R., et al.: J. Med. Chem., 46, 642 (2003), Andrade, E., et al.: Chem. Biodivers., 5, 197 (2008),<br></p>Fórmula:C10H10O3Cor e Forma:NeatPeso molecular:178.18(±)-Ibuprofen-d3, Sodium Salt (α-methyl-d3)
CAS:Produto Controlado<p>Applications (±)-Ibuprofen-d3, Sodium Salt (alpha-methyl-d3) (CAS# 1219805-09-0) is a useful isotopically labeled research compound.<br></p>Fórmula:C13H14D3NaO2Cor e Forma:NeatPeso molecular:231.29Nabumetone Dimer Impurity
CAS:Produto Controlado<p>Impurity Nabumetone Dimer Impurity<br>Applications An impurity in a Nabumetone (N200500) drug substance.<br>References Friedel, H., et al.: Drugs, 35, 504 (1988), Davies, N., et al.: Clin. Pharmacokinet., 33, 403 (1997),<br></p>Fórmula:C27H26O3Cor e Forma:NeatPeso molecular:398.49N-Desethyl 3-Bromo Lidocaine
CAS:Produto Controlado<p>Applications Intermediate in the preparation of hydroxylated Lidocaine metabolites.<br></p>Fórmula:C12H17BrN2OCor e Forma:NeatPeso molecular:285.182-Hydroxy Nabumetone
CAS:Produto ControladoFórmula:C15H18O2Cor e Forma:White To Off-WhitePeso molecular:230.306-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, racemic
CAS:<p>6-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, racemic is a drug product that is used as an analytical standard in the development of new drugs. It is also used to study the metabolism of drugs. 6BPDC has been shown to inhibit bacterial growth by binding to DNA and RNA, thereby preventing transcription and replication. This metabolite can be synthesized in the laboratory.</p>Fórmula:C15H13NO3Pureza:Min. 95%Peso molecular:255.27 g/mol
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