Derivados de Benzimidazol e Imidazol
O benzimidazol é um composto constituído por um anel benzênico fundido a um anel imidazólico, uma estrutura de cinco membros contendo dois átomos de nitrogénio. Os derivados de benzimidazol, como o albendazol, são conhecidos pela sua atividade antiparasitária e antifúngica, sendo utilizados no tratamento de infeções parasitárias e de algumas doenças parasitárias em animais e humanos. O imidazol, por sua vez, é uma estrutura de cinco membros com dois átomos de nitrogénio, presente em diversos compostos biologicamente ativos. Os derivados de imidazol, como o metronidazol, possuem propriedades antimicrobianas e antiparasitárias. Estes compostos também são utilizados na indústria farmacêutica para tratar infeções bacterianas, doenças parasitárias e algumas infeções fúngicas, além de terem aplicações na química orgânica como catalisadores.
Na CymitQuimica, oferecemos benzimidazóis e imidazóis de alta pureza para investigação em química medicinal, farmacologia e biotecnologia.
Foram encontrados 10345 produtos de "Derivados de Benzimidazol e Imidazol"
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4,9-Diisobutyl-1,6-diazecane-2,7-dione
CAS:Produto Controlado<p>Applications 4,9-Diisobutyl-1,6-diazecane-2,7-dione is in impurity of rac-Pregabalin (P704800) which is a GABA analogue used as an anticonvulsant.<br>References Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993), Field, M.J., et al.: Pain, 80, 391 (1999)<br></p>Fórmula:C16H30N2O2Cor e Forma:NeatPeso molecular:282.42cis-Hydroxy Solifenacin (Mixture of Diastereomers)
CAS:Produto Controlado<p>Applications Solifenacin (S676700) metabolite.<br>References Naito, R., et al.: J. Med. Chem., 48, 6597 (2005), Krauwinkel, W., et al.: Int. J. Clin. Pharmacol. Ther., 43, 227 (2005),<br></p>Fórmula:C23H26N2O3Cor e Forma:NeatPeso molecular:378.462,5-Dichlorobenzoyl Cyanide
CAS:Produto Controlado<p>Applications 2,5-Dichlorobenzoyl Cyanide is a reagent applied for research purposes<br>References Veerareddy, A., et al.: J. Heterocyclic Chem., 51, 1311 (2014)<br></p>Fórmula:C8H3Cl2NOCor e Forma:NeatPeso molecular:200.0222-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride
CAS:Produto Controlado<p>Impurity Omeprazole EP Impurity XI<br>Applications 2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride (Omeprazole EP Impurity XI) is an intermediate in the production of the antiulcer agent Omeprazole.<br>References Roma, G., et al.: J. Med. Chem., 50, 2886 (2007), Hoffmann, S., et al.: Toxicol. Lett., 180, 9 (2008),<br></p>Fórmula:C9H12ClNO·ClHCor e Forma:WhitePeso molecular:222.11(2-Chlorophenyl)diphenylmethane
CAS:Produto Controlado<p>Applications (2-Chlorophenyl)diphenylmethane is a triarylmethane with antiproliferative activity. (2-Chlorophenyl)diphenylmethane is an impurity of the antifungal agent Clotrimazole (C587400).<br>References Al-Qawasmeh, R.A. et al.: Bioorg. Med. Chem. Lett., 14, 347 (2004);<br></p>Fórmula:C19H15ClCor e Forma:NeatPeso molecular:278.78(R)-1-Methyl-3-pyrrolidinol
CAS:Produto Controlado<p>Applications (R)-1-Methyl-3-pyrrolidinol is a useful synthetic intermediate. It is used for asymmetric synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors.<br>References Isakovic, L., et al.: Bioorg. Med. Chem. Lett., 19, 2742 (2009); Gobbini, M., et al.:J. Med. Chem., 51, 4601 (2008)<br></p>Fórmula:C5H11NOCor e Forma:NeatPeso molecular:101.151-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid Sodium Salt
CAS:<p>Applications 1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid is an impurity of Rabeprazole. It is also a degradation product formed in stressed tablets of Rabeprazole sodium.<br>References Kommanaboyina, B., et al.: Drug Dev. Ind. Pharm., 25, 857 (1999); Carswel, C., et al.: Drugs, 61, 2327 (2001); Garcia, C., et al.: J. Pharm. Biomed. Anal., 46, 88 (2008)<br></p>Fórmula:C14H10N3NaO3Cor e Forma:NeatPeso molecular:291.244-Fluorobenzonitrile
CAS:Produto Controlado<p>Applications 4-Fluorobenzonitrile is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wan, J. et al.: Org. Lett., 15, 2742 (2013); Kormos, C. et al.: J. Med. Chem., 56, 4551 (2013);<br></p>Fórmula:C7H4FNCor e Forma:NeatPeso molecular:121.11Omeprazole Sodium Salt
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Omeprazole Sodium Salt is the salt analogue of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>Fórmula:C17H18N3O3S·Na·H2OCor e Forma:Off-WhitePeso molecular:385.41Trimebutine EP Impurity E-Nitroso
Produto ControladoFórmula:C21H26N2O6Cor e Forma:NeatPeso molecular:402.441ent-Voriconazole
CAS:Produto Controlado<p>Impurity Voriconazole EP Impurity D; Voriconazole USP Related Compound B<br>Applications ent-Voriconazole (Voriconazole USP Related Compound B; Voriconazole EP Impurity D) is the (2S,3R) enantiomer in Voriconazole (V760000) drug substance.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gage, R., et al.: J. Pharm. Biomed. Anal., 17, 1449 (1998), Owens, P., et al.: Enantiomer, 4, 79 (1999), Pehourcq, F., et al.: Biomed. Chromatogr., 18, 719 (2004), Sellers, J., et al.: J. Pharm. Biomed. Anal., 41, 1088 (2006),<br></p>Fórmula:C16H14F3N5OCor e Forma:NeatPeso molecular:349.314-Acetoxy Midazolam
CAS:Produto Controlado<p>Applications A metabolite of Midazolam (M343000).<br></p>Fórmula:C20H15ClFN3O2Cor e Forma:NeatPeso molecular:383.80Lurasidone Opened Imide (Mixture of Diastereomers)
CAS:Produto Controlado<p>Applications Lurasidone Opened Imide is an impurity in the synthesis of Lurasidone (L474920) which is antipsychotic used for treatment of schizophrenia.<br>References Ishiyama, T., et al.: Eur. J. Pharmacol., 572, 160 (2007); Cole, P., et al.: Drugs of the Fut., 33, 316 (2008);<br></p>Fórmula:C28H38N4O3SCor e Forma:NeatPeso molecular:510.691',4-Dihydroxy Midazolam
CAS:Produto Controlado<p>Applications A metabolite of Midazolam (M343000).<br>References Soucek, P., et al.: Xenobiotica, 22, 83 (1992), Ghosal, A., et al.: Drug Metab. Dispos., 24, 940 (1996), Kobayashi, K., et al.: Biochem. Pharmacol., 63, 889 (2002),<br></p>Fórmula:C18H13ClFN3O2Cor e Forma:NeatPeso molecular:357.77(S)-Rivastigmine
CAS:<p>Applications S-Rivastigmine is an isomer of Rivastigmine ( an acetylcholinesterase inhibitor used in the treatment of neurological disorders such as Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Howes, L et al.: Drug. Safe., 37, 391 (2014); Shahar, O. et al.: Nucl. Acids Res., 42, 5869 (2014);<br></p>Fórmula:C14H22N2O2Cor e Forma:ColourlessPeso molecular:250.344-Hydroxy Triazolam
CAS:Produto Controlado<p>Stability Light Sensitive<br>Applications A metabolite of Triazolam (T767380).<br>References Gall, M., et al.: J. Med. Chem., 21, 1290 (1978), Jones, H., et al.: Drug Metab. Dispos., 32, 973 (2004), Hallifax, D., et al.: Drug Metab. Dispos., 33, 1852 (2005).<br></p>Fórmula:C17H12Cl2N4OCor e Forma:NeatPeso molecular:359.214,4'-(Bromomethylene)dibenzonitrile
CAS:Produto Controlado<p>Applications 4,4'-(1-Bromomethyl)bis-benzonitrile (CAS# 69545-39-7) is a useful research chemical compound.<br></p>Fórmula:C15H9BrN2Cor e Forma:NeatPeso molecular:297.1492,2'-Ethylenedianiline
CAS:Produto Controlado<p>Applications 2,2'-Ethylenedianiline is used as a reagent to synthesize Oxcarbazepine (O869250), a broad-specturm, second-generation anticonvulsant drug that is used to treat partial and complex partial seizures in children and adults. 2,2'-Ethylenedianiline is also used as a reagent to prepare a series of triterpines (e.g. Lupeol [L474850]), compounds that have chemopreventative activity.<br>References Asmaa, M., et al.: Pac. J. Cancer Prevent., 15, 475 (2014); Kalis, M. & Huff, N.: Clin. Ther., 23, 680 (2001); Malke, S., et al.: Pharm. Sci., 69, 211 (2007); Schmidt, D. & Elger, C.: Epil. Beh., 5, 627 (2004)<br></p>Fórmula:C14H16N2Cor e Forma:NeatPeso molecular:212.292-Deschlorothien-3-yl Tioconazole Hydrochloride
CAS:Produto Controlado<p>Applications 2-Deschloro Tioconazole Hydrochloride is an analog of Tioconazole (T444680), an antifungal that is more active than Fluconazole (F421000) or Voriconazole (V760000) against Candida glabrata mutant strains. Antifungal (topical).<br>References Jevons, S., et al.: Antimicrob. Agents Chemother., 15, 597 (1979), Clayton, Y.M., et al.: Clin. Exp. Dermatol., 7, 543 (1982), Marriott, M.S., et al.: Dermatologica, 166, 1 (1983),<br></p>Fórmula:C16H14Cl2N2OS·ClHCor e Forma:NeatPeso molecular:389.7310-Acetyloxy Oxcarbazepine
CAS:Produto Controlado<p>Applications An intermediate in the preparation of Carbamazepine metabolites.<br>References Heckendorn, R., et al.: Helv. Chimica Acta, 70, 1955 (1987),<br></p>Fórmula:C17H14N2O4Cor e Forma:NeatPeso molecular:310.30(3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl Acetate
CAS:Produto Controlado<p>Impurity Lansoprazole<br>Applications (3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl Acetate is an impurity of Lansoprazole (L175000). Lansoprazole is used as a gastric proton pump inhibitor and an antiulcerative. It May limit the severity of tuberculosis.<br>References Figgitt, D., et al.: Drugs, 60, 925 (2000); Katsuki, H., et al.: Eur. J. Clin. Pharmacol., 57, 709 (2001); Barradell, L.B., et al.: Drugs, 44, 225 (1992); Kim, K., et al.: Clin. Pharmacol. Ther., 72, 90 (2002); Niioka, T., et al.: Ther. Drug Monit., 28, 321 (2006); Chem. and Eng. News. p. 28 July 20 (2018)<br></p>Fórmula:C11H12F3NO3Cor e Forma:NeatPeso molecular:263.213Hydroxy Varenicline N-Trifluoroacetic Acid Salt
CAS:Produto Controlado<p>Applications Protected Varenicline metabolite.<br></p>Fórmula:C15H12F3N3O2Cor e Forma:NeatPeso molecular:323.27Triazolam-d3
CAS:Produto Controlado<p>Applications Labelled Triazolam (T767380(M)). Triazolam in an hypnotic drug used in the short term treatment of insomnia.<br>References Lomen, P., et al.: J. Int. Med. Res., 4, 55 (1976), Allens, G.S., et al.: J. Int. Med. Res., 6, 343 (1978), Pakes, G.E., et al.: Drugs, 22, 81 (1981).<br></p>Fórmula:C17H9D3Cl2N4Cor e Forma:NeatPeso molecular:346.23Metopimazine-d6
CAS:Produto Controlado<p>Applications Labelled Metopimazine (MPZ) is used to prevent emesis during chemotherapies. Antiemetic.<br>References Catz, P., et al.: Int. J. Pharm., 58, 93 (1990), Sato, K., et al.: J. Pharm. Sci., 80, 104 (1991), Herrstedt, J., et al.: Cancer Chemother. Pharmacol., 33, 53 (1996), Sigsgaard, T., et al.: J. Clin. Onc., 19, 2091 (2001),<br></p>Fórmula:C22H21D6N3O3S2Cor e Forma:NeatPeso molecular:451.64Itraconazole Desethylene-seco-piperazine Di-N-formyl Impurity
CAS:Produto Controlado<p>Applications Itraconazole Desethylene-seco-piperazine Di-N-formyl Impurity is a by-product in the synthesis of Itraconazole Desethylene-seco-piperazine Mono-N-formyl Impurity (I937520), which is an impurity of Itraconazole (I937500). Itraconazole is an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.<br>References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),<br></p>Fórmula:C35H36Cl2N8O6Cor e Forma:NeatPeso molecular:735.62N-Methyl Omeprazole-d3 (Mixture of isomers with the methylated nitrogens of imidazole)
CAS:Produto Controlado<p>Applications Labelled Omeprazole (O635000) impurity.<br>References Allenmark, S., et al.: Anal. Biochem., 136, 293 (1984), Besancon, M., et al.: J. Biol. Chem., 272, 22438 (1997),<br></p>Fórmula:C18H18D3N3O3SCor e Forma:NeatPeso molecular:362.46(Chloromethyl)cyclohexane
CAS:Produto Controlado<p>Applications (Chloromethyl)cyclohexane is a common chemical reagent used in the synthesis of imidazole inhibitors of cytokine release which suppresses the response to tumor necrosis factor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Laufer, S. et al., J. Med. Chem., 45, 1695 (2002); Rabinowitz, M. et al.: J. Med. Chem., 44, 4252 (2001);<br></p>Fórmula:C7H13ClCor e Forma:NeatPeso molecular:132.6310-Chloro Carbamazepine
CAS:<p>Applications 10-Chloro Carbamazepine is a derivative of Carbamazepine (C175840) which is used in treatment of pain associated with trigeminal neuralgia.<br>References Stenger, E.G., et al.: Med. Exp., 11, 191 (1964), Pynnonen, S., et al.: Ther. Drug Monit., 1, 409 (1979), Sidebottom, A., et al.: J. Clin. Pharm. Ther., 20, 31 (1995)<br></p>Fórmula:C15H11ClN2OCor e Forma:White PowderPeso molecular:270.71rac N-Demethyl Promethazine-d3 Hydrochloride
CAS:Produto Controlado<p>Applications Labelled Promethazine (P757000) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Keipert, S., et al.: Pharmazie, 31, 296 (1976),<br></p>Fórmula:C16H16D3ClN2SCor e Forma:NeatPeso molecular:309.87Noratropine Hydrochloride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A metabolite of Atropine (A794625). Two metabolites of Atropine (apoatropine and noratropine) were found in rat urine.<br>References Xu, A., et al.: J. Pharm. Biomed. Anal., 14, 33 (1995), Cherkaoui, S., et al.: J. Pharm. Biomed. Anal., 17, 1167 (1998),<br></p>Fórmula:C16H21NO3·HClCor e Forma:BrownPeso molecular:311.802-Chloromethyl-4-methoxy-3-methylpyridine Hydrochloride
CAS:Produto Controlado<p>Applications A pyridine derivative used in the preparation of anti-ulcerative agents and other pharmaceutical compounds.<br>References Kuehler, T.C. et al.: J. Med. Chem., 38, 4906 (1995);<br></p>Fórmula:C8H10ClNO·ClHCor e Forma:NeatPeso molecular:208.08Propantheline-d3 Iodide
CAS:Produto Controlado<p>Applications Labelled Propantheline (P760900). Propantheline is an antimuscarinic agent used in the treatment of hyperhidrosis (excessive sweating), enuresis (involuntary urination) as well as cramps or spasms of the stomach, intestine and bladder.<br>References Levin, R. et al.: Neurol. Urodyn., 1, 221 (1982); Daniotti, S. et al.: Br. J. Pharmacol., 82, 305 (1984); Moller, J. et al .: Acta Med. Scand., 184, 201 (1968);<br></p>Fórmula:C23H27D3INO3Cor e Forma:NeatPeso molecular:498.414'-Desmethoxy Omeprazole
CAS:Produto Controlado<p>Applications 4'-Desmethoxy Omeprazole is one of two impurities in the synthesis of Esomeprazole, an anti-ulcerative drug for treatment of acid-related diseases.<br>References Liu, X., et al.: Lat. Am. J. Pharm., 34, 1265-1268 (2015);<br></p>Fórmula:C16H17N3O2SCor e Forma:NeatPeso molecular:315.39N-Nitroso Aryl Lurasidone
CAS:Produto ControladoFórmula:C11H12N4OSCor e Forma:NeatPeso molecular:248.316-Ethyl-5-fluoropyrimidin-4(3H)-one
CAS:Produto Controlado<p>Applications A pyrimidine derivative used in the preparation of bio-active compounds such as broad-spectrum triazole antifungal agents.<br>References Butters, M. et al.: Org. Proc. Res. Dev., 5, 28 (2001); Tong, L. et al.: Zhong. Yao., 8, 280 (2010);<br></p>Fórmula:C6H7FN2OCor e Forma:NeatPeso molecular:142.132-Cyclopropylmethylamino-5-chlorobenzophenone
CAS:Produto Controlado<p>Applications: 2-Cyclopropylmethylamino-5-chlorobenzophenone is a benzodiazepine derivative.<br>References Japp, M. et al.: J. Chrom., 439, 317 (1988); Guan, F. et al.: J. Anal Toxicol., 23, 54 (1999);<br></p>Fórmula:C17H16ClNOCor e Forma:NeatPeso molecular:285.774-Hydroxy Midazolam-d5 Methanoate
CAS:Produto Controlado<p>Applications A labelled metabolite of Midazolam (M343000).<br>References Ha, H., et al.: Ther. Drug Monit., 15, 338 (1993), Thummel, K., et al.: J. Pharmacol. Exp. Ther., 271, 557 (1994), Kim, R., et al.: Pharm. Res., 16, 408 (1999), Maurer, H., et al.: Anal. Bioanal. Chem., 381, 110 (2005), Smink, B., et al.: J. Anal. Toxicol., 30, 478 (2006),<br></p>Fórmula:C19H12D5ClFN3O2Cor e Forma:NeatPeso molecular:378.84Lansoprazole Sulfone N-Oxide
CAS:Produto Controlado<p>Applications An impurity of Lansoprazole.<br>References Barradell, L., et al.: Drugs, 44, 225 (1992), Aydogmus, Z., et al.: Acta Pharm. Sci., 48, 45 (2006), El-Sherif, Z., et al.: Chem. Pharm. Bull., 54, 814 (2006),<br></p>Fórmula:C16H14F3N3O4SCor e Forma:WhitePeso molecular:401.36trans-Itraconazole
CAS:Produto Controlado<p>Impurity Itraconazole EP Impurity E<br>Applications trans-Itraconazole (Itraconazole EP Impurity E) is a geometrical isomer of Itraconazole (I937500). It is a COVID19-related research product.<br>References Ahn, C., et al.: J. Korean Chem. Soc., 43, 676 (1999),<br></p>Fórmula:C35H38Cl2N8O4Cor e Forma:NeatPeso molecular:705.63β-Ketoglutaric Acid
CAS:<p>Stability Unstable in Solution<br>Applications β-Ketoglutaric Acid is used in the synthesis of benzodiazepine derivatives. Also used in the synthesis of orally available hepatitis C virus polymerase inhibitors.<br>References Jung, D. et al.: Synth. Comm., 29, 1941 (1999); Li, H. et al.: J. Med. Chem., 52, 1255 (2009);<br></p>Fórmula:C5H6O5Cor e Forma:Off White PowderPeso molecular:146.098(S)-Aclidinium Bromide
CAS:Produto Controlado<p>Applications (S)-Aclidinium Bromide is an isomer of Aclidinium Bromide (A190180) a novel long-acting antimuscarinic bronchodilator in phase II clinical trials for the treatment of chronic obstructive pulmonary disease (1,2).<br>References (1) Gupta, V. and Singh, D.: Expert Rev Respir Med. 6, 581 (2012)(2) De La Motte, S., et al.: Int. J. Clin. Pharmacol. Therap., 50,403 (2012)<br></p>Fórmula:C26H30BrNO4S2Cor e Forma:Off-WhitePeso molecular:564.55cis-Hydroxy Solifenacin N-Oxide(Mixture of Diastereomers)
Produto Controlado<p>Applications Solifenacin (S676700) metabolite.<br></p>Fórmula:C23H26N2O4Cor e Forma:NeatPeso molecular:394.46PD 224378
CAS:Produto Controlado<p>Stability Very Hygroscopic<br>Applications PD 224378 is a lactose conjugate degradation product of pregabalin (P704800), a GABA analogue used as an anticonvulsant.<br>References Lovdahl, M.J., et al.: J. Pharma. Biomed. Anal., 28, 917 (2002);<br></p>Fórmula:C20H35NO11Cor e Forma:NeatPeso molecular:465.49(2Z)-2-[Cyano(2,3-dichlorophenyl)methylene]hydrazinecarboximidamide
CAS:Produto ControladoFórmula:C9H7Cl2N5Cor e Forma:NeatPeso molecular:256.095,6-Dimethoxyindane-1,3-dione
CAS:Produto ControladoFórmula:C11H10O4Cor e Forma:NeatPeso molecular:206.19
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