Derivados de Benzimidazol e Imidazol
O benzimidazol é um composto constituído por um anel benzênico fundido a um anel imidazólico, uma estrutura de cinco membros contendo dois átomos de nitrogénio. Os derivados de benzimidazol, como o albendazol, são conhecidos pela sua atividade antiparasitária e antifúngica, sendo utilizados no tratamento de infeções parasitárias e de algumas doenças parasitárias em animais e humanos. O imidazol, por sua vez, é uma estrutura de cinco membros com dois átomos de nitrogénio, presente em diversos compostos biologicamente ativos. Os derivados de imidazol, como o metronidazol, possuem propriedades antimicrobianas e antiparasitárias. Estes compostos também são utilizados na indústria farmacêutica para tratar infeções bacterianas, doenças parasitárias e algumas infeções fúngicas, além de terem aplicações na química orgânica como catalisadores.
Na CymitQuimica, oferecemos benzimidazóis e imidazóis de alta pureza para investigação em química medicinal, farmacologia e biotecnologia.
Foram encontrados 10345 produtos de "Derivados de Benzimidazol e Imidazol"
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Isometronidazole-D4
CAS:Produto Controlado<p>Applications Isometronidazole-D4 is a labelled analogue of Isometronidazole (I821342). Isometronidazole is an impurity of Metronidazole (M338880), a chemotherapeutic agent that is used as a first line defense against Clostridium difficile (C.diff). Isometronidazole is also a hypoxic cell sensitizer in humans and mice.<br>References Hentschel, M. & Schmidt, W.: Die Pharm., 47, 221 (1992); Musher, D., et al.: Clin. Inf. Dis., 40, 1586 (2005); Rosenkranz, H. & Speck, W.: Biochem. Biophys. Res. Comm., 66, 520 (1975)<br></p>Fórmula:C6D4H5N3O3Cor e Forma:NeatPeso molecular:175.183,4-Dihydro-1-phenylisoquinoline Hydrochloride
CAS:Produto Controlado<p>Stability Light Sensitive<br>Applications 3,4-Dihydro-1-phenylisoquinoline has been shown to have anesthetic properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Moore, M.B., et. al.: J. Am. Chem. Soc., 76, 3656 (1954)<br></p>Fórmula:C15H13N·ClHCor e Forma:NeatPeso molecular:243.73rac N-Demethyl Promethazine-d3 Hydrochloride
CAS:Produto Controlado<p>Applications Labelled Promethazine (P757000) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Keipert, S., et al.: Pharmazie, 31, 296 (1976),<br></p>Fórmula:C16H16D3ClN2SCor e Forma:NeatPeso molecular:309.873-Hydroxy-1-methyl-1-Azoniabicyclo[2.2.2]octane Bromide
CAS:Produto Controlado<p>Applications 3-Hydroxy-1-methyl-1-Azoniabicyclo[2.2.2]octane is an impurity in the synthesis of Clidinium Bromide (C576250), an anticholinergic. Used as an antispasmodic.<br>References Zhang, L., et al.: Pharm. Res., 25, 1902 (2008), Sanderson, H., et al.: Toxicol Lett., 187, 84 (2009),<br></p>Fórmula:C8H16BrNOCor e Forma:NeatPeso molecular:222.124-Hydroxy Triazolam
CAS:Produto Controlado<p>Stability Light Sensitive<br>Applications A metabolite of Triazolam (T767380).<br>References Gall, M., et al.: J. Med. Chem., 21, 1290 (1978), Jones, H., et al.: Drug Metab. Dispos., 32, 973 (2004), Hallifax, D., et al.: Drug Metab. Dispos., 33, 1852 (2005).<br></p>Fórmula:C17H12Cl2N4OCor e Forma:NeatPeso molecular:359.21Metopimazine
CAS:<p>Applications Metopimazine (MPZ) is used to prevent emesis during chemotherapies. Antiemetic.<br>References Catz, P., et al.: Int. J. Pharm., 58, 93 (1990), Sato, K., et al.: J. Pharm. Sci., 80, 104 (1991), Herrstedt, J., et al.: Cancer Chemother. Pharmacol., 33, 53 (1996), Sigsgaard, T., et al.: J. Clin. Onc., 19, 2091 (2001),<br></p>Fórmula:C22H27N3O3S2Cor e Forma:Off White SolidPeso molecular:445.60β-Ketoglutaric Acid
CAS:<p>Stability Unstable in Solution<br>Applications β-Ketoglutaric Acid is used in the synthesis of benzodiazepine derivatives. Also used in the synthesis of orally available hepatitis C virus polymerase inhibitors.<br>References Jung, D. et al.: Synth. Comm., 29, 1941 (1999); Li, H. et al.: J. Med. Chem., 52, 1255 (2009);<br></p>Fórmula:C5H6O5Cor e Forma:Off White PowderPeso molecular:146.0984-Hydroxy Midazolam-d5 Methanoate
CAS:Produto Controlado<p>Applications A labelled metabolite of Midazolam (M343000).<br>References Ha, H., et al.: Ther. Drug Monit., 15, 338 (1993), Thummel, K., et al.: J. Pharmacol. Exp. Ther., 271, 557 (1994), Kim, R., et al.: Pharm. Res., 16, 408 (1999), Maurer, H., et al.: Anal. Bioanal. Chem., 381, 110 (2005), Smink, B., et al.: J. Anal. Toxicol., 30, 478 (2006),<br></p>Fórmula:C19H12D5ClFN3O2Cor e Forma:NeatPeso molecular:378.844,4'-Dibromobenzophenone
CAS:Produto Controlado<p>Applications 4,4'-Dibromobenzophenone is a reagent used in the synthesis of polyelectrolytes which serve as fluorescent visualizers for intracellular imaging with good biocompatibility.<br>References Hu, R., et al.: Chem. Asian J., 8, 2436-2445 (2013)<br></p>Fórmula:C13H8Br2OCor e Forma:Yellow Orange To BrownPeso molecular:340.014'-Desmethoxy Omeprazole
CAS:Produto Controlado<p>Applications 4'-Desmethoxy Omeprazole is one of two impurities in the synthesis of Esomeprazole, an anti-ulcerative drug for treatment of acid-related diseases.<br>References Liu, X., et al.: Lat. Am. J. Pharm., 34, 1265-1268 (2015);<br></p>Fórmula:C16H17N3O2SCor e Forma:NeatPeso molecular:315.39Metopimazine-d6
CAS:Produto Controlado<p>Applications Labelled Metopimazine (MPZ) is used to prevent emesis during chemotherapies. Antiemetic.<br>References Catz, P., et al.: Int. J. Pharm., 58, 93 (1990), Sato, K., et al.: J. Pharm. Sci., 80, 104 (1991), Herrstedt, J., et al.: Cancer Chemother. Pharmacol., 33, 53 (1996), Sigsgaard, T., et al.: J. Clin. Onc., 19, 2091 (2001),<br></p>Fórmula:C22H21D6N3O3S2Cor e Forma:NeatPeso molecular:451.64N-Carbamoyl Carbamazepine
CAS:Produto Controlado<p>Impurity Carbamazepine EP Impurity C<br>Applications Carbamazepine (C175840) impurity.<br></p>Fórmula:C16H13N3O2Cor e Forma:NeatPeso molecular:279.299-Acridinecarboxylic acid
CAS:Produto Controlado<p>Applications 9-Acridinecarboxylic acid is used in the synthesis of short DNA-binding peptides.<br></p>Fórmula:C14H9NO2Cor e Forma:YellowPeso molecular:223.231,2-Bismethylenecyclohexane (~75%)
CAS:Produto ControladoFórmula:C8H12Pureza:~75%Cor e Forma:NeatPeso molecular:108.18(2-Chlorophenyl)diphenylmethane
CAS:Produto Controlado<p>Applications (2-Chlorophenyl)diphenylmethane is a triarylmethane with antiproliferative activity. (2-Chlorophenyl)diphenylmethane is an impurity of the antifungal agent Clotrimazole (C587400).<br>References Al-Qawasmeh, R.A. et al.: Bioorg. Med. Chem. Lett., 14, 347 (2004);<br></p>Fórmula:C19H15ClCor e Forma:NeatPeso molecular:278.78N-Desethyl N-Methyl Rivastigmine
CAS:Produto Controlado<p>Impurity Rivastigmine EP Impurity B<br>Applications N-Desethyl N-Methyl Rivastigmine (Rivastigmine EP Impurity B) is an impurity of Rivastigmine (R541000), a brain selective acetylcholinesterase inhibitor. Nootropic.<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999), Enz, A., et al.: Prog. Brain Res., 98, 431 (1993),<br></p>Fórmula:C13H20N2O2Cor e Forma:NeatPeso molecular:236.326-Ethyl-5-fluoropyrimidin-4(3H)-one
CAS:Produto Controlado<p>Applications A pyrimidine derivative used in the preparation of bio-active compounds such as broad-spectrum triazole antifungal agents.<br>References Butters, M. et al.: Org. Proc. Res. Dev., 5, 28 (2001); Tong, L. et al.: Zhong. Yao., 8, 280 (2010);<br></p>Fórmula:C6H7FN2OCor e Forma:NeatPeso molecular:142.13Tofenacin Hydrochloride Salt-d4
CAS:Produto Controlado<p>Applications A labelled metabolite of Orphenadrine (O695300). An antidepressant prodrug.<br>References Watkins, P., et al.: J. Biol. Chem., 261, 6264 (1986), McNeil, C., et al.: Biochem. Pharmacol., 51, 15 (1996), Hiessbock, R., et al.: J. Med. Chem., 42, 1921 (1999),<br></p>Fórmula:C17H18D4ClNOCor e Forma:NeatPeso molecular:295.84(2R,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl methanesulfonate
CAS:Produto ControladoFórmula:C13H15F2N3O4SCor e Forma:NeatPeso molecular:347.34(R)-1-Methyl-3-pyrrolidinol
CAS:Produto Controlado<p>Applications (R)-1-Methyl-3-pyrrolidinol is a useful synthetic intermediate. It is used for asymmetric synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors.<br>References Isakovic, L., et al.: Bioorg. Med. Chem. Lett., 19, 2742 (2009); Gobbini, M., et al.:J. Med. Chem., 51, 4601 (2008)<br></p>Fórmula:C5H11NOCor e Forma:NeatPeso molecular:101.152-Chloroacetamide
CAS:Produto Controlado<p>Applications A component of herbicidal mixtures of cellulose biosynthesis inhibitors with VLCFA inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Aptula, A., et al.: Chem. Res. Toxicol., 19, 1097 (2006), Chan, K., et al.: J. Appl. Toxicol., 28, 608 (2008),<br></p>Fórmula:C2H4ClNOCor e Forma:WhitePeso molecular:93.51Trimebutine-d9 Maleate Salt
CAS:Produto Controlado<p>Applications Trimebutine-d9 Maleate Salt, is the labeled analogue of Trimebutine Maleate Salt (T795605), acting as an opioid receptor agonist. Antispasmodic.<br>References Delvaux, M., et al.: J. Int. Med. Res., 25, 225 (1997), Lavit, M., et al.: Arzneim.-Forsch., 50, 640 (2000),<br></p>Fórmula:C22H20D9NO5·C4H4O4Cor e Forma:NeatPeso molecular:512.6(alphaS)-N,N,α-Trimethyl-3-(4-nitrophenoxy)benzenemethanamine
CAS:Produto Controlado<p>Applications (αS)-N,N,α-Trimethyl-3-(4-nitrophenoxy)benzenemethanamine is an impurity of Rivastigmine Tartrate (R541000). Rivastigmine Tartrate is a brain selective acetylcholinesterase inhibitor.<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999); Enz, A., et al.: Prog. Brain Res., 98, 431 (1993)<br></p>Fórmula:C16H18N2O3Cor e Forma:OrangePeso molecular:286.331-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid (>75%)
CAS:<p>Impurity Rabeprazole EP Impurity C<br>Applications 1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid (>75%) (Rabeprazole EP Impurity C) is a Rabeprazole (R070500) impurity. A degradation product formed in stressed tablets of Rabeprazole sodium.<br>References Kommanaboyina, B., et al.: Drug Dev. Ind. Pharm., 25, 857 (1999), Carswel, C., et al.: Drugs, 61, 2327 (2001), Garcia, C., et al.: J. Pharm. Biomed. Anal., 46, 88 (2008),<br></p>Fórmula:C14H11N3O3Pureza:>75%Cor e Forma:NeatPeso molecular:269.262,2'-Ethylenedianiline
CAS:Produto Controlado<p>Applications 2,2'-Ethylenedianiline is used as a reagent to synthesize Oxcarbazepine (O869250), a broad-specturm, second-generation anticonvulsant drug that is used to treat partial and complex partial seizures in children and adults. 2,2'-Ethylenedianiline is also used as a reagent to prepare a series of triterpines (e.g. Lupeol [L474850]), compounds that have chemopreventative activity.<br>References Asmaa, M., et al.: Pac. J. Cancer Prevent., 15, 475 (2014); Kalis, M. & Huff, N.: Clin. Ther., 23, 680 (2001); Malke, S., et al.: Pharm. Sci., 69, 211 (2007); Schmidt, D. & Elger, C.: Epil. Beh., 5, 627 (2004)<br></p>Fórmula:C14H16N2Cor e Forma:NeatPeso molecular:212.294,9-Diisobutyl-1,6-diazecane-2,7-dione
CAS:Produto Controlado<p>Applications 4,9-Diisobutyl-1,6-diazecane-2,7-dione is in impurity of rac-Pregabalin (P704800) which is a GABA analogue used as an anticonvulsant.<br>References Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993), Field, M.J., et al.: Pain, 80, 391 (1999)<br></p>Fórmula:C16H30N2O2Cor e Forma:NeatPeso molecular:282.42N-trifluoroacetyl Varenicline
CAS:Produto Controlado<p>Applications 7,8,9,10-Tetrahydro-8-(trifluoroacetyl)-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine is used to prepare varenicline, which is a smoking cessation. It is a Varenicline protected impurity.<br>References Coe, J., et al.: J. Med. Chem., 48, 3474 (2005) ;<br></p>Fórmula:C15H12F3N3OCor e Forma:NeatPeso molecular:307.2705N-Methyl Omeprazole-d3 (Mixture of isomers with the methylated nitrogens of imidazole)
CAS:Produto Controlado<p>Applications Labelled Omeprazole (O635000) impurity.<br>References Allenmark, S., et al.: Anal. Biochem., 136, 293 (1984), Besancon, M., et al.: J. Biol. Chem., 272, 22438 (1997),<br></p>Fórmula:C18H18D3N3O3SCor e Forma:NeatPeso molecular:362.462-Chlorobenzotrichloride
CAS:Produto Controlado<p>Applications 2-Chlorobenzotrichloride is a chlorinated toluene with mutagenicity.<br>References Mineki, S. et al.: Mat. technol., 23, 413 (2005); Matsushita, H. et al.: Indust. Health., 17, 199 (1979);<br></p>Fórmula:C7H4Cl4Cor e Forma:NeatPeso molecular:229.924-Desmethoxypropoxyl-4-chloro Rabeprazole Sulfide
CAS:Produto Controlado<p>Applications A process impurity of Rabeprazole (R070500).<br>References Pingili, R.R., et al.: Pharmazie, 60, 814 (2005),<br></p>Fórmula:C14H12ClN3SCor e Forma:NeatPeso molecular:289.78Triazolam-d3
CAS:Produto Controlado<p>Applications Labelled Triazolam (T767380(M)). Triazolam in an hypnotic drug used in the short term treatment of insomnia.<br>References Lomen, P., et al.: J. Int. Med. Res., 4, 55 (1976), Allens, G.S., et al.: J. Int. Med. Res., 6, 343 (1978), Pakes, G.E., et al.: Drugs, 22, 81 (1981).<br></p>Fórmula:C17H9D3Cl2N4Cor e Forma:NeatPeso molecular:346.23N-Nitroso Albendazole (mixtures of regional isomers)
Produto ControladoFórmula:C13H16N4O3SCor e Forma:NeatPeso molecular:616.712Metronidazole β-D-Glucuronide
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A metabolite of Metronidazole.<br>References Kokwaro, G.O., et al.: Biochem. Pharmacol., 45, 1243 (1993), Sidelmann, U.G. , et al.: Xenobiotica, 26, 709 (1996),<br></p>Fórmula:C12H17N3O9Cor e Forma:NeatPeso molecular:347.284-{[4-(4-Methyloxyphenyl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]-triazol-3-one
CAS:Produto Controlado<p>Applications 4-{[4-(4-Methyloxyphenyl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]-triazol-3-one, is an intermediate for the synthesis of Itraconazole (I937500), an Antifungal.<br></p>Fórmula:C19H21N5O2Cor e Forma:NeatPeso molecular:351.404-Acetoxy Midazolam
CAS:Produto Controlado<p>Applications A metabolite of Midazolam (M343000).<br></p>Fórmula:C20H15ClFN3O2Cor e Forma:NeatPeso molecular:383.80Oxybutynin-d10 Hydrochloride
CAS:Produto Controlado<p>Applications Oxybutynin-d10 Hydrochloride is a labeled analogue of Oxybutynin Chloride (O868525), an inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells.<br>References Park, J.M., et al.: J. Urol., 162, 1110 (1999); Watson, M., et al.: Brit. J. Pharmacol., 127, 590 (1999)<br></p>Fórmula:C22H22D10ClNO3Cor e Forma:NeatPeso molecular:404.01(S)-Modafinil-d10
CAS:Produto Controlado<p>Applications Labelled (S)-Modafinil. Used for treatment of excessive sleepiness, α1-adrenoceptor agonist.<br>References Saletu, B., et al.: Int. J. Clin. Pharmacol. Res., 9, 183 (1989), Chemelli, R.M., et al.: Cell, 98, 437 (1999), Purnell, M., et al.: J. Sleep Res., 11, 219 (2002), Dinges, D., et al.: Curr. Med. Res. Opin., 22, 159 (2006)<br></p>Fórmula:C15D10H5NO2SCor e Forma:NeatPeso molecular:283.4110-Chloro Carbamazepine
CAS:<p>Applications 10-Chloro Carbamazepine is a derivative of Carbamazepine (C175840) which is used in treatment of pain associated with trigeminal neuralgia.<br>References Stenger, E.G., et al.: Med. Exp., 11, 191 (1964), Pynnonen, S., et al.: Ther. Drug Monit., 1, 409 (1979), Sidebottom, A., et al.: J. Clin. Pharm. Ther., 20, 31 (1995)<br></p>Fórmula:C15H11ClN2OCor e Forma:White PowderPeso molecular:270.71Lurasidone Opened Imide (Mixture of Diastereomers)
CAS:Produto Controlado<p>Applications Lurasidone Opened Imide is an impurity in the synthesis of Lurasidone (L474920) which is antipsychotic used for treatment of schizophrenia.<br>References Ishiyama, T., et al.: Eur. J. Pharmacol., 572, 160 (2007); Cole, P., et al.: Drugs of the Fut., 33, 316 (2008);<br></p>Fórmula:C28H38N4O3SCor e Forma:NeatPeso molecular:510.69Scopolamine Sulfate
CAS:Produto Controlado<p>Applications Scopolamine Sulfate is an impurity of Scopolamine (S200000), an acetylcholine antagonist used in the treatment of motion sickness and also used as antiemetic, antispasmodic, mydriatic, preanesthetic agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Trendelenburg P., et al.: Archiv fuer Exper. Pathol. Pharmacol., 73, 118 (1914);<br></p>Fórmula:C17H21NO7SCor e Forma:NeatPeso molecular:383.42Hydroxy Varenicline N-Trifluoroacetic Acid Salt
CAS:Produto Controlado<p>Applications Protected Varenicline metabolite.<br></p>Fórmula:C15H12F3N3O2Cor e Forma:NeatPeso molecular:323.2710,11-Dihydro Carbamazepine
CAS:Produto ControladoFórmula:C15H14N2OCor e Forma:WhitePeso molecular:238.28Midazolam-d6 (1 mg/mL in Acetonitrile)
CAS:Produto ControladoFórmula:C18D6H7ClFN3Cor e Forma:Single SolutionPeso molecular:331.80Voriconazole-d3 N-Oxide (~90%)
CAS:Produto ControladoFórmula:C16D3H11F3N5O2Pureza:~90%Cor e Forma:NeatPeso molecular:368.332-(Ethylthio)ethanol
CAS:Produto Controlado<p>Applications 2-(Ethylthio)ethanol is used to prepare aryldihydropyrimidinones as inhibitors of fatty acid transporter FATP4.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Blackburn, C., et al.: Bioorg. Med. Chem. Lett., 16, 3504 (2006)<br></p>Fórmula:C4H10OSCor e Forma:NeatPeso molecular:106.19(E)-Ethyl 2-cyano-5-methylhex-2-enoate
CAS:Produto ControladoFórmula:C10H15NO2Cor e Forma:NeatPeso molecular:335.429(3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl Acetate
CAS:Produto Controlado<p>Impurity Lansoprazole<br>Applications (3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl Acetate is an impurity of Lansoprazole (L175000). Lansoprazole is used as a gastric proton pump inhibitor and an antiulcerative. It May limit the severity of tuberculosis.<br>References Figgitt, D., et al.: Drugs, 60, 925 (2000); Katsuki, H., et al.: Eur. J. Clin. Pharmacol., 57, 709 (2001); Barradell, L.B., et al.: Drugs, 44, 225 (1992); Kim, K., et al.: Clin. Pharmacol. Ther., 72, 90 (2002); Niioka, T., et al.: Ther. Drug Monit., 28, 321 (2006); Chem. and Eng. News. p. 28 July 20 (2018)<br></p>Fórmula:C11H12F3NO3Cor e Forma:NeatPeso molecular:263.213
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![4-{[4-(4-Methyloxyphenyl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]-triazol-3-one](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FM266245.webp&w=3840&q=75)
