Derivados de Purinas e Pirimidinas
As purinas possuem uma estrutura bicíclica, formada por um anel de seis membros fundido a um anel de cinco membros, ambos contendo átomos de nitrogênio em posições-chave. Os derivados das purinas, como a adenina e a guanina, são essenciais para a formação do DNA e RNA. Estes compostos possuem aplicações terapêuticas no tratamento do câncer e de doenças virais, pois inibem a replicação celular. As pirimidinas, por outro lado, possuem uma estrutura monocíclica de seis membros com dois átomos de nitrogênio. Seus derivados, como citosina, timina e uracila, também são componentes essenciais do DNA e RNA e são utilizados na quimioterapia e em tratamentos antivirais.
Na CymitQuimica, oferecemos derivados de purinas e pirimidinas para pesquisa em biologia molecular, genômica e desenvolvimento de terapias inovadoras.
Foram encontrados 8895 produtos de "Derivados de Purinas e Pirimidinas"
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2-Oxo Clopidogrel-13C,d3 Hydrochloride(Mixture of Diastereomers)
CAS:Produto ControladoFórmula:C1513CH14D3Cl2NO3SCor e Forma:NeatPeso molecular:378.292,4-Diamino-6-(hydroxymethyl)pteridine Hydrochloride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Methotrexate intermediate.<br>References Feng, Y., et al.: J. Med. Chem., 49, 770 (2006),<br></p>Fórmula:C7H8N6O·ClHCor e Forma:YellowPeso molecular:228.64nPOC-POC Tenofovir Fumarate(Mixture of Diastereomers)
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Tenofovir (T018500) impurity.<br></p>Fórmula:C19H30N5O10P·C4H4O4Cor e Forma:White To Off-WhitePeso molecular:635.51Caffeine Citrate
CAS:<p>Applications Caffeine citrate (Cafcit) is a citrate salt of Caffeine, sometimes used in medical treatment, including short-term treatment of apnea of prematurity (lack of breathing in premature infants). Caffeine citrate functions in much the same capacity as does caffeine, but takes effect more quickly; its speed of dissociation is faster than that of Caffeine. Caffeine citrate is typically only used to treat severe migraines.<br>References Zubair, U.M., et al.: Anal. Profiles Drug Subs., 15, 71 (1986); Cherrah, Y., et al.: Biochem. Pharmacol., 37, 1311 (1988); Grillon, C., et al.: Clin. Neurophysiol., 114, 1557 (2003); Duangdao, D., et al.: Behav. Brain Res., 205, 1 (2009);<br></p>Fórmula:C8H10N4O2·C6H8O7Cor e Forma:WhitePeso molecular:386.314-Hydroxy-1,3-benzenedicarbonitrile
CAS:Produto Controlado<p>Applications 4-Hydroxy-1,3-benzenedicarbonitrile is used in the preparation of febuxostat (F229000), a non-purine xanthine oxidase inhibitor used as a treatment for hyperuricaemia and chronic gout.<br>References Smith, C.J., et al.: Bioorg. Med. Chem. Lett., 20, 346 (2010); Cramp. S., et al.: BIoorg. Med. Chem. Lett., 20, 2516 (2010); Sato, T., et al.: Bioorg. Med. Chem. Lett., 19, 184 (2009);<br></p>Fórmula:C8H4N2OCor e Forma:NeatPeso molecular:144.13rac-Clopidogrel Carboxylic Acid Hydrochloride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications rac-Clopidogrel Carboxylic Acid Hydrochloride is a salt metabolite of rac-Clopidogrel.<br></p>Fórmula:C15H15Cl2NO2SCor e Forma:NeatPeso molecular:344.26Picolinamide
CAS:Produto Controlado<p>Applications A nicotinic acid derivative for prevention and treatment of cancer by activating RUNX3 gene.<br>References Ludwig, et al.: Cancer Res., 50, 2470 (1990), Gupta., et al.: Biomed. Environ. Sci., 13,122 (2000), Cai., et al.: J. Med. Chem., 46, 2474 (2003),<br></p>Fórmula:C6H6N2OCor e Forma:NeatPeso molecular:122.128-13C-Uric Acid (contains ~1.5% unlabelled)
CAS:Produto Controlado<p>Applications 8-13C-Uric Acid is the labeled analogue of Uric Acid (U829200), a heterocyclcic compound that is created when purine nucleotides are broken down of by the human body. High blood concetration of Uric Acid is known as hyperuricemia and is often associated with a wide range of disorders and medical conditions such as gout, diabetes and metabolic syndrome. Uric acid may be a marker of oxidative stress and may have a potential therapeutic role as an antioxidant.<br>References Heinig, M. et al.: Cle. Clin. J. Med., 73, 1059 (2006); Glantzounis, G.K. et al.: Curr. Pharmac. Des., 11, 4145 (2005); Dehghan, A. et al.: Diab. Care, 31, 361 (2008); Nakagawa, T. et al.: Am. J. Physiol. Renal Physiol., 290, F625 (2006)<br></p>Fórmula:C413CH4N4O3Cor e Forma:NeatPeso molecular:169.1(1R,5R,6R)-5-(1-Ethylpropoxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic Acid Ethyl Ester
CAS:Produto Controlado<p>Applications This compound is an isomer of compound (E925685) used in the synthesis of neuraminidase inhibitors.<br>References Jarinrat K. et al.: Bioorg. Med. Chem. Lett., 20, 2152 (2012);<br></p>Fórmula:C14H22O4Cor e Forma:NeatPeso molecular:254.32(R)- 3-[(1-Methyl-2-pyrrolidinyl)methyl]-1H-Indole
CAS:Produto ControladoFórmula:C14H18N2Cor e Forma:NeatPeso molecular:214.31Febuxostat 67M-2
CAS:Produto Controlado<p>Applications Febuxostat 67M-2 is a derivative compound of Febuxostat 67M-1 (F229005) which is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and also used to reduce the risk of gout or kidney stone formation.<br>References Du, J., et al.: Handbook of Metabolic Pathways of Xenobiotics, 4, 1395 (2014)<br></p>Fórmula:C16H16N2O4SCor e Forma:NeatPeso molecular:332.37Mono-POC Tenofovir 6-Isopropyl Carbamate (Mixture of Diastereomers)
CAS:Produto Controlado<p>Stability Very Hygroscopic<br>Applications Tenofovir (T018500) impurity.<br></p>Fórmula:C18H28N5O9PCor e Forma:White SolidPeso molecular:489.426-Oxo-(S,S)-Palonosetron (~90%)
CAS:Produto Controlado<p>Applications 6-Oxo-(S,S)-Palonosetron is an impurity of (S,S)-Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.<br>References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),<br></p>Fórmula:C19H22N2O2Pureza:~90%Cor e Forma:NeatPeso molecular:310.395-Hydroxymethyl-N,N-dimethyltryptamine
CAS:Produto Controlado<p>Applications Degradation product of Sumatriptan Succinate (S810000).<br>References Xu, X. et al.: J. Pharmaceut. Biomed. 367, 26 (2001)<br></p>Fórmula:C13H18N2OCor e Forma:WhitePeso molecular:218.29N-(5-Aminopentyl) Methotrexate Amide
CAS:Produto Controlado<p>Applications The 5-aminopentyl amide derivative of the folic acid antagonist Methotrexate (M260675) used in the study of membrane-associated folate transporters from L1210 cells.<br>References Fan, J. et al.: J. Biol. Chem., 266, 14862 (1991);<br></p>Fórmula:C25H34N10O4Cor e Forma:NeatPeso molecular:538.6nPOC-POC Tenofovir(Mixture of Diastereomers)
CAS:Produto Controlado<p>Applications An impurity of Tenofovir (T018500(P)). Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Fórmula:C19H30N5O10PCor e Forma:NeatPeso molecular:519.44Ethyl 2-(4-Butoxy-3-cyanophenyl)-4-methylthiazole-5-carboxylate
Produto Controlado<p>Applications Ethyl 2-(4-Butoxy-3-cyanophenyl)-4-methylthiazole-5-carboxylate, is an impurity in the synthesis of Febuxostat n-Butyl Isomer (F229035).<br></p>Fórmula:C18H20N2O3SCor e Forma:NeatPeso molecular:344.43(N,N-Dimethyl-1-butanamine) Zolmitriptan Dimer
CAS:Produto Controlado<p>Impurity Zolmitriptan USP Related Compound F<br>Stability Hygroscopic<br>Applications (N,N-Dimethyl-1-butanamine) Zolmitriptan Dimer (Zolmitriptan USP Related Compound F) is an impurity from the synthesis of Zolmitriptan (Z639000). Zolmitriptan is a Serotonin 5HTID-receptor agonist.<br>References Glen, R.C., et al.: J. Med. Chem., 38, 3566 (1995), Seaber, E., et al.: Brit. J. Clin. Pharmacol., 41, 141 (1996), Tepper, S.J., et al.: Curr. Med. Res. Opin., 15, 254 (1999)<br></p>Fórmula:C38H53N7O4Pureza:>90%Cor e Forma:NeatPeso molecular:671.87Valbenazine (~90% Purity)
CAS:Produto Controlado<p>Applications Valbenzine is a highly selective vesicular monoamine transporter 2 inhibitor. It is used in the treatment of tardive dykinesia.<br>References O'Brien, C. et al.: Movement Dis., 30, 1681 (2015);<br></p>Fórmula:C24H38N2O4Pureza:~90%Cor e Forma:NeatPeso molecular:418.572-Pyrimidinemethanamine
CAS:Produto Controlado<p>Applications 2-Pyrimidinemethanamine (cas# 75985-45-4) is a useful research chemical.<br></p>Fórmula:C5H7N3Cor e Forma:NeatPeso molecular:109.13
![(1R,5R,6R)-5-(1-Ethylpropoxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic Acid Ethyl Ester](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FE925690.webp&w=3840&q=75)
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