Derivados de Quinazolina e Quinolina
As quinazolinas e quinolinas são compostos heterocíclicos contendo nitrogénio, com estruturas aromáticas que desempenham um papel fundamental na síntese de fármacos com atividade anticancerígena, antimicrobiana e anti-inflamatória. Os seus derivados apresentam modificações estruturais que otimizam a biodisponibilidade e a seletividade, permitindo o desenvolvimento de novos princípios ativos para diversas aplicações terapêuticas. Estes compostos são utilizados na fabricação de APIs para o tratamento do câncer, infeções, doenças neurodegenerativas e cardiovasculares. Além disso, os derivados de quinazolina e quinolina são essenciais na investigação de inibidores enzimáticos e no desenvolvimento de moléculas bioativas inovadoras.
Na CymitQuimica, oferecemos derivados de quinazolina e quinolina de alta pureza para aplicações em síntese química, desenvolvimento farmacêutico e biotecnologia.
Foram encontrados 65562 produtos de "Derivados de Quinazolina e Quinolina"
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[2-(1H-indol-3-yl)ethyl][(pyridin-4-yl)methyl]amine hydrochloride
CAS:Pureza:95.0%Peso molecular:287.79000854492197-Hydroxy Quetiapine
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic.<br>References Newton, D., et al.: Drug Metab. Dispos., 23, 154 (1995), Tanaka, E., et al.: J. Clin. Pharm. Ther., 24, 7 (1999)<br></p>Fórmula:C21H25N3O3SCor e Forma:WhitePeso molecular:399.511,2-DIMETHYL-4-OXO-N-PHENYL-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE
CAS:Pureza:95.0%Peso molecular:292.3380126953125Methylchloroisothiazolinone/Methylisothiazolinone Mixture
CAS:<p>Methylchloroisothiazolinone/Methylisothiazolinone Mixture (Kathon 886MW),a preservative, activates MMPs in human bronchial epithelial cells.</p>Fórmula:C8H9ClN2O2S2Cor e Forma:SolidPeso molecular:264.75Dibenzyloxy Tezacaftor-D4
Produto ControladoFórmula:C40H35D4F3N2O6Cor e Forma:NeatPeso molecular:704.78[1-(2-Chloro-pyridine-3-carbonyl)-piperidin-3-ylmethyl]-carbamic acid tert-butyl ester
CAS:Pureza:95.0%Peso molecular:353.8500061035156Vemurafenib
CAS:Produto Controlado<p>Applications Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600. Potent B-Raf inhibitor<br>References Halaban, R. et al.: Pigm. Cell. Melonoma Res., 23, 190 (2010); Yang, H. et al.: Cancer Res., 70, 5518 (2010); Comin-Anduix, B. et al.: Clin. Cancer Res., 16, 6040 (2010);<br></p>Fórmula:C23H18ClF2N3O3SCor e Forma:NeatPeso molecular:489.921-(4-Bromophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid hydrazide
CAS:Fórmula:C11H11BrN4OPureza:95.0%Peso molecular:295.144,4',4''-((1,3,5-TRIAZINE-2,4,6-TRIYL)TRIS(OXY))TRIBENZALDEHYDE
CAS:Pureza:95%Peso molecular:441.39898681640625Ref: 10-F852142
1g43,00€5g148,00€10g273,00€25g665,00€50g1.158,00€100g2.301,00€100mgA consultar250mgA consultar2-(2,3-Dimethoxybenzoyl)-5-(1,3-dioxolan-2-yl)thiophene
CAS:Pureza:97.0%Peso molecular:320.35998535156252-Phenylbutyric Acid
CAS:Produto ControladoFórmula:C10H12O2Cor e Forma:White To Off-WhitePeso molecular:164.2Famotidine-d4 (Major)
CAS:Produto Controlado<p>Applications Famotidine-d4 is the labeled analogue of Famotidine (F102250), a histamine H2-receptor antagonist. Antiulcerative.<br>References Takeda, M., et al.: Arzneim.-Forsch., 32, 734 (1982); Miwa, M., et al.: J. Clin. Pharmacol. Ther. Toxicol., 22, 214 (1984); Takabatke, T., et al.: Eur. J. Clin. Pharmacol., 28, 327 (1985)<br></p>Fórmula:C8H11D4N7O2S3Cor e Forma:NeatPeso molecular:341.47(R)-tert-Butyl 2-((7-chloropyrido[4,3-b]pyrazin-5-ylamino)methyl)morpholine-4-carboxylate
CAS:Pureza:97.0%Peso molecular:379.8500061035156(3-Amino-pyrrolidin-1-yl)-thiophen-2-yl-methanone hydrochloride
CAS:Pureza:95.0%Peso molecular:232.729995727539063,5-(Dimethyl-1H-pyrazol-4yl)methylamine
CAS:Pureza:95.0%Cor e Forma:LiquidPeso molecular:125.17500305175781Phenylbutazone-d9
CAS:Produto ControladoFórmula:C192H9H11N2O2Cor e Forma:White To Light BrownPeso molecular:317.43Mirtazapine N-Glucuronide (Mixture of Diastereomers) Contains Unknown Inorganics >80%
CAS:Produto Controlado<p>Applications Mirtazapine N-Glucuronide is a metabolite of Mirtazapine (M365000), an α2-Adrenergic blocker; analogue of Mianserin. Antidepressant.<br>References Smith, D.A., RSC Drug Discovery Series, 1, 193 (2010); De Boer, T., et al.: Neuropharmacology, 27, 399 (1988); Smith, W.T., et al.: Psychopharmacol. Bull., 26, 191 (1990)<br></p>Fórmula:C23H28N3O6Pureza:>80%Cor e Forma:NeatPeso molecular:442.48Demethylpiperazinyl 7-Desoxo 7-Thioxosildenafil Sulfonic Acid
CAS:Produto ControladoFórmula:C17H20N4O4S2Cor e Forma:Off White SolidPeso molecular:408.50Nizatidine-d3
CAS:Produto Controlado<p>Applications Labelled Nizatidine. Histamine H2-receptor antagonist related to Ranitidine (R120000). Antiulcerative.<br>References Callaghan, J.T., et al.: Clin. Pharmacol. Ther., 37, 162 (1985), Secor, J.W., et al.: Br. J. Clin. Pharmacol., 20, 710 (1985), Knadler, M.P., et al.: Drug Metab. Dispos., 14, 175 (1986), Wozniak, T.J., et al.: Anal. Profiles Drug Subs., 19, 397(1990)<br></p>Fórmula:C12D3H18N5O2S2Cor e Forma:Light Yellow SolidPeso molecular:334.486-(1-METHYL-1H-PYRAZOL-4-YL)-3-((2-METHYL-2H-INDAZOL-5-YL)THIO)-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZINE
CAS:Pureza:95.0%Peso molecular:362.4200134277344Minoxidil-d10
CAS:Produto Controlado<p>Applications Deuterated Minoxidil, which is used as an antihypertensive and antialopecia agent. Minoxidil activates ATP-activated K+ channels.<br>References Franz, T.J., Arch. Dermatol., 121, 203 (1985), Gadwood, R.C., et al.: Annu. Rep. Med. Chem., 24, 187 (1989), Hautala, T., et al.: Biochem. J., 283, 51 (1992)<br></p>Fórmula:C92H10H5N5OCor e Forma:White To Off-WhitePeso molecular:219.31Dimetridazole-d3
CAS:Produto Controlado<p>Applications Labelled Dimetridazole (D479660). An antihistomonal agent. Antiprotozoal (Histomonas).<br>References Butler, K., et al.: J. Med. Chem., 10, 891 (1967), Mitrovic, M., et al.:; Antimicrob. Agents Chemother., 445, 1968, Mitrovic, M., et al.: Poult. Sci., 49, 86 (1970),<br></p>Fórmula:C52H3H4N3O2Cor e Forma:Off-WhitePeso molecular:144.151-(3,4-Dichlorophenyl)piperazine
CAS:Produto ControladoFórmula:C10H12Cl2N2Cor e Forma:NeatPeso molecular:231.12N-Desmethyl Clozapine-d8
CAS:Produto Controlado<p>Applications A major labelled metabolite of clozapine. A potent and selective 5-HT2C serotonin receptor antogonist.<br>References Kuoppamaki, M. et al.: Eur. J. Pharm. Mol. Pharm. Sect., 245, 179 (1993), Olessen, O.V., et al.: J. Chromatog., 622, 39 (1993), Pirmohamed, M., et al.: J. Pharmacol. Exp. Ther., 272, 984 (1995)<br></p>Fórmula:C172H8H9ClN4Cor e Forma:Light YellowPeso molecular:320.85Diclazuril 6-Carboxylic Acid
CAS:Produto Controlado<p>Applications Diclazuril 6-Carboxylic Acid is an impurity of Diclazuril (D436200), a nucleotide analog with broad-spectrum anticoccidial activity.<br>References Fodey, T.L., et al.: J. Immunol. Meth., 323, 31 (2007);<br></p>Fórmula:C18H9Cl3N4O4Cor e Forma:NeatPeso molecular:451.65N,N'-Dicyclohexylurea
CAS:Produto Controlado<p>Impurity Lomustine USP Related Compound C<br>Applications N,N'-Dicyclohexylurea,is a substituted Urea (U822500) compound, which has shown to be a potent inhibitor of juvenile hormone epoxide hydrolase (JHEH) of the tobacco hornworm M. sexta. Lomustine USP Related Compound C.<br>References Garriga, M., et al.: Chemosphere, 82, 1604 (2011)<br></p>Fórmula:C13H24N2OCor e Forma:Light YellowPeso molecular:224.344-Cyano-3-trifluoromethylphenylisothiocyanate
CAS:Produto ControladoFórmula:C9H3F3N2SCor e Forma:NeatPeso molecular:228.19Olanzapine LIP 1 Acetyl
CAS:<p>Applications Olanazpine LIP 1 Acetyl is an Olanazpine impurity. Olanazpine is an antipsychotic medicine.<br>References Perera, V., et al.: Br. J. Clin. Pharmacol., 78, 800 (2014); Pratt, N., et al.: Pharmacoepidemiol. Drug Saf., 22, 915 (2013)<br></p>Fórmula:C18H20N4OSCor e Forma:YellowPeso molecular:340.444-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-iodo-2-methoxy-benzamide
CAS:<p>Impurity Amisulpride EP Impurity C<br>Applications 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-iodo-2-methoxy-benzamide is an impurity of Amisulpride (A633250), an antipsychotic. Amisulpride is a dopamine receptor antagonist. (Amisulpride EP Impurity C). Dopamine imaging agent<br>References Protais, P., et al.: Neuropharmacol., 24, 861 (1985), Perrault, G., et al.: J. Pharmacol. Exp. Ther., 280, 73 (1997),<br></p>Fórmula:C15H22IN3O2Cor e Forma:NeatPeso molecular:403.26cis-Tadalafil
CAS:Produto Controlado<p>Impurity Tadalafil EP Impurity A<br>Applications The (6R)-cis-enantiomer of Tadalafil (T004500). Tadalafil Impurity (6R,12aS)<br>References Aldridge, J., et al.: Br. Med. J., 318, 669 (1999), Daugan, A., et al.: J. Med. Chem., 46, 4533 (2003), Vredenbregt, M., et al.: J. Pharm. Biomed. Anal., 40, 840 (2006),<br></p>Fórmula:C22H19N3O4Cor e Forma:Off-WhitePeso molecular:389.402-Hydroxymethyl Loratadine
CAS:Produto Controlado<p>Impurity Loratadine 2-Hydroxymethyl Impurity (USP)<br>Applications A usual impurity in Loratadine syrup formulations, a nonsedating-type histamine H1-receptor. Loratadine 2-Hydroxymethyl Impurity (USP).<br>References Okamoto, T., et al.: Chem. Pharm. Bull ., 7, 130 (1959), Eyjolfsson, R., et al.: Pharmazie, 58, 154 (2003),<br></p>Fórmula:C23H25ClN2O3Cor e Forma:NeatPeso molecular:412.91Tadalafil-d3
CAS:Produto Controlado<p>Stability Unstable in Methanol<br>Applications Tadalafil is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003), Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005), Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005),<br></p>Fórmula:C222H3H16N3O4Cor e Forma:White SolidPeso molecular:392.424-OXO-5-(THIOPHEN-2-YLMETHYL)-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE-3-CARBOXYLIC ACID
CAS:Pureza:95.0%Peso molecular:277.29998779296875Hydrolyzed Pomalidomide M11
CAS:Produto ControladoFórmula:C13H13N3O5Cor e Forma:NeatPeso molecular:291.26(R)-(+)-4’-Hydroxyphenyl Carvedilol
CAS:Produto Controlado<p>Applications An optically active metabolite of Carvedilol (C184625), a nonselective ß-adrenergic blocker with α1-blocking activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., ET AL.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 10, 958 (1998),<br></p>Fórmula:C24H26N2O5Cor e Forma:NeatPeso molecular:422.47Telmisartan-d3 Acyl-β-D-glucuronide
CAS:Produto Controlado<p>Applications Labelled Telmisartan Acyl-β-D-glucuronide (T017010). Telmisartan Acyl-β-D-glucuronide is a metabolite of Telmisartan (T017000).<br>References Abe, T., et al.: J. Biol. Chem., 274, 17159 (1999), Hirano, M., et al.: Drug Metab. Dispos., 34, 1229 (2006),<br></p>Fórmula:C39H35D3N4O8Cor e Forma:NeatPeso molecular:693.76Levosimendan
CAS:<p>Applications Bioactive enantiomer of racemate, Simendan. Positive inotropic agent with vasodilating activity. Cardiotonic.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995), Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996),<br></p>Fórmula:C14H12N6OCor e Forma:Yellow To Dark YellowPeso molecular:280.287-(4-Bromobutoxy)-3,4-dihydroquinolin-2-one
CAS:Produto Controlado<p>Impurity Aripiprazole Bromobutoxyquinoline Impurity<br>Stability Hygroscopic<br>Applications An impurity in the synthesis of Aripiprazole (A771000). A degradation product in Aripiprazole tablets. Aripiprazole Bromobutoxyquinoline Impurity<br>References Reddy, G.V.R., et al.: Eur. J. Chem., 1, 20 (2010),<br></p>Fórmula:C13H16BrNO2Cor e Forma:White To Off-WhitePeso molecular:298.18rac-Talinolol
CAS:Produto Controlado<p>Applications Selective β1-adrenergic blocker structurally related to Practolol. Antihypertensive; antiarrhythmic.<br>References Assmann, I., et al.: Curr. Med. Res. Opin., 13, 325 (1995), Trausch, B., et al.: Biopharm. Drug Dispos., 16, 403 (1995),<br></p>Fórmula:C20H33N3O3Cor e Forma:White To Light PinkPeso molecular:363.49
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