Derivados de Quinazolina e Quinolina
As quinazolinas e quinolinas são compostos heterocíclicos contendo nitrogénio, com estruturas aromáticas que desempenham um papel fundamental na síntese de fármacos com atividade anticancerígena, antimicrobiana e anti-inflamatória. Os seus derivados apresentam modificações estruturais que otimizam a biodisponibilidade e a seletividade, permitindo o desenvolvimento de novos princípios ativos para diversas aplicações terapêuticas. Estes compostos são utilizados na fabricação de APIs para o tratamento do câncer, infeções, doenças neurodegenerativas e cardiovasculares. Além disso, os derivados de quinazolina e quinolina são essenciais na investigação de inibidores enzimáticos e no desenvolvimento de moléculas bioativas inovadoras.
Na CymitQuimica, oferecemos derivados de quinazolina e quinolina de alta pureza para aplicações em síntese química, desenvolvimento farmacêutico e biotecnologia.
Foram encontrados 65562 produtos de "Derivados de Quinazolina e Quinolina"
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Carmustine
CAS:Produto Controlado<p>Stability Temperature Sensitive<br>Applications An alkylating and carbamoylating nitrosourea compound. It interacts with DNA, RNA and proteins causing DNA interstrand cross linking which is cytotoxic and leads to apoptotic cell death.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stahl, et al.: Chem. Res. Toxicol., 5, 106 (1992), Kokkinakis, D.M., et al.: Clin. Cancer Res., 5(11), 3676 (1999), Hickman, M.J., et al.: Proc. Natl. Acad. Sci. USA, 96(19), 10764 (1999),<br></p>Fórmula:C5H9Cl2N3O2Cor e Forma:Light Yellow To Light Orange ColourPeso molecular:214.05Seleno-D,L-ethionine
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Used as a substrate for methionine adenosyltransferase from rat liver.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lombardini, J.B., et al.: Biochem. Pharmacol., 32(3), 489 (1983), Kajander, E., et al.: Cancer Res., 46 (6), 2866 (1986), Kajander, E., et al.: Biochem. J., 267 (3), 767 (1990)<br></p>Fórmula:C6H13NO2SeCor e Forma:Off-White To Light BeigePeso molecular:210.137-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid, 90%
CAS:Produto Controlado<p>Impurity Norfloxacin EP Impurity A; Norfloxacin USP Related Compound A (7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-d<br>Applications 7-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid (Norfloxacin EP Impurity A) is a Norfloxacin intermediate. Norfloxacin EP Impurity A; Norfloxacin USP Related Compound A (7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid).<br>References Piganeau, N., et al.: J. Mol. Biol., 312, 1177 (2001), Rameshkumar, N., et al.: Eur. J. Med. Chem., 38, 1001 (2003), You, Q., et al.: J. Med. Chem., 52, 5649 (2009),<br></p>Fórmula:C12H9ClFNO3Pureza:90%Cor e Forma:NeatPeso molecular:269.66(S)-4,5,6,7-Tetrahydro-N2,N6-propionyl-2,6-benzothiazolediamine
CAS:Produto Controlado<p>Applications Pramipexole derivative.<br></p>Fórmula:C13H19N3O2SCor e Forma:NeatPeso molecular:281.37Dipyridamole Tri(diethanolamine)
CAS:Produto Controlado<p>Impurity Dipyridamole EP Impurity B<br>Applications Dipyridamole Tri(diethanolamine) (Dipyridamole EP Impurity B) Dipyridamole (D492625) impurity.<br>References Gerlach, E., et al.: Arzneim.-Forsch., 15, 558 (1965),<br></p>Fórmula:C23H40N8O6Cor e Forma:NeatPeso molecular:524.61N-Nitrosometoprolol
CAS:<p>Applications N-Nitrosometoprolol is an N-nitroso derivative of rac Metoprolol(M338815), which is a β1 selective aryloxypropanolamine andrenergic antagonist. Used in the treatment of a variety of cardiovascular disorder. N-Nitrosometoprolol can be used to assess human and rat hepatocytes.<br>References McGourty, J.C., et al.: Br. J. Clin. Pharmacol. 20, 555 (1985); Lennard, M.S., et al.: Biochem. Pharmacol., 35, 2757 (1986); Martelli, A., In Vivo, 11, 189-194, (1997);<br></p>Fórmula:C15H24N2O4Cor e Forma:Colourless To Light YellowPeso molecular:296.36(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Ethyl Ester
CAS:Produto ControladoFórmula:C15H13F2NO4Cor e Forma:Off-White To Light YellowPeso molecular:309.26(E)-N-Methylcinnamylamine Hydrochloride
CAS:Produto Controlado<p>Applications (E)-N-Methylcinnamylamine is an 3-amino-1-phenyl-prop-1-ene derivative with potential to inhibit and inactivate monoamine oxidase.<br>References Williams, C.H. et al.: Biochim. Biophys. Acta Prot. Struc. Mol. Enzymol., 119, 111 (1992);<br></p>Fórmula:C10H14ClNCor e Forma:NeatPeso molecular:183.684-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
CAS:Produto Controlado<p>Applications 4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide is a compound used as a reagent to synthesize Regorafenib (R143000), a multikinase inhibitor that is used to treat patients with advanced colorectal cancer.<br>References Mross, K., et al.: Clin. Cancer Res., 18, 2658 (2012); Stiehl, J., et al. Process for Preparation of Regorafenib. PCT Int. Appl. 2011128261. Oct 20, 2011; Van Cutsem, E., et al.: J. Clin. Oncol., 30, 3502 (2012)<br></p>Fórmula:C13H12FN3O2Cor e Forma:Dark Orange To Red BrownPeso molecular:261.25Des(benzylpyridyl) Atazanavir
CAS:Produto Controlado<p>Applications The N-dealkylated metabolite (M1) of Atazanavir (A790051), a HIV protease inhibitor.<br>References Heine, R., et al.: Drug Metab. Dispos., 37, 1826 (2009),<br></p>Fórmula:C26H43N5O7Cor e Forma:White To Off-WhitePeso molecular:537.65cis-Hydroxy Perhexiline-d11 (Mixture of Diastereomers)
CAS:Produto Controlado<p>Applications A labelled metabolite of Perhexiline.<br>References Shah, R., et al.: Br. Med. J., 284, 295 (1982), Gould, B., et al.: Xenobiotica, 16, 491 (1986), Marquet, P., et al.: Ther. Drug Monit., 24, 255 (2002), Sallustio, B., et al.: Br. J. Clin. Pharmacol., 54, 107 (2002),<br></p>Fórmula:C19D11H24NOCor e Forma:NeatPeso molecular:304.56Dehydro Felodipine-d3
CAS:Produto ControladoFórmula:C18H14D3Cl2NO4Cor e Forma:NeatPeso molecular:385.26Desethyl Terbuthylazine-d9
CAS:Produto ControladoFórmula:C72H9H3ClN5Cor e Forma:Off White SolidPeso molecular:210.71Rivaroxaban
CAS:<p>Applications A novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Fórmula:C19H18ClN3O5SCor e Forma:White To BeigePeso molecular:435.88Perazine Dihydrochloride
CAS:<p>Applications Antipsychotic.<br>References Hromatka, et al.: Monatsh. Chem., 88, 56 (1957), Franke, U., et al.: J. Pharm. Sci., 88, 89 (1999), Hashem, H., et al.: Pharmazie, 60, 186 (2005),<br></p>Fórmula:C20H25N3S·2ClHCor e Forma:NeatPeso molecular:412.42Dacarbazine-d6
CAS:Produto Controlado<p>Applications Labelled Dacarbazine (D101400). Dacarbazine is used as an antineoplastic for treatment of malignant melanoma and sarcomas.<br>References Shealy, et al.: Biochem. Pharmacol., 11, 674 (1962), Carter, et al.: Eur. J. Cancer, 8, 85 (1972),<br></p>Fórmula:C62H6H4N6OCor e Forma:Light Yellow SolidPeso molecular:188.22Cyclohexylmethyl 5-(1,3-dioxolan-2-yl)-2-thienyl ketone
CAS:Pureza:97.0%Peso molecular:280.3800048828125(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran
CAS:Produto Controlado<p>Applications (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran is used as a reactant in the efficient synthesis of empagliflozin inhibitor of SGLT-2 utilizing AlCl3-promoted silane reduction of β-glycopyranoside.<br>References Wang, X., et al.: Org. Lett., 16, 4090 (2014);<br></p>Fórmula:C17H16BrClO2Cor e Forma:Off-WhitePeso molecular:367.6610α-Hydroxy Naloxone
CAS:Produto Controlado<p>Impurity Naloxone EP Impurity C<br>Applications 10α-Hydroxy Naloxone is a hydroxylated analog of the opioid antagonist Naloxone (N285000(P)), which is a specific opioid antagonist; narcotic antagonist.<br>References Jasinski, D.R., et al.: J. Pharmacol. Exp. Ther., 157, 420 (1967), McNicholas, L.F., et al.: Drugs, 27, 81 (1984), Hasson, M.M.A., et al.: Anal. Profiles Drug Subs., 14, 453 (1985), Stowe, C., et al.: Ann. Pharmacother., 27, 447 (1993)<br></p>Fórmula:C19H21NO5Cor e Forma:NeatPeso molecular:343.372-(4,6-Bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl)-5-(octyloxy)phenol
CAS:Pureza:98%Peso molecular:509.6940002441406Methyl 4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)benzoate
CAS:Pureza:95.0%Peso molecular:356.3850097656256-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-1-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butyl]-3,4-dihydro-2(1H)-quinolinone
CAS:Produto Controlado<p>Impurity Cilostazol USP Related Compound C<br>Applications 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-1-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butyl]-3,4-dihydro-2(1H)-quinolinone, is an impurity of Cilostazol (C441500), a potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake.<br>References Suri, A., et al.: J. Clin. Pharmacol., 38, 144 (1998), Park, S.-W., et al.: Am. J. Cardiol., 84, 511 (1999), Tsuchikane, E., et al.: Circulation, 100, 21 (1999);<br></p>Fórmula:C31H45N9O2Cor e Forma:NeatPeso molecular:575.75Vildagliptin Cyclo Imidamide
CAS:<p>Applications Vildagliptin Cyclo Imidamide Hydrochloride is an impurity of vildagliptin (V305000). Glyptins are class of oral anti-hyperglycemic agents that inhibit dipeptidyl peptidase 4 (DPP-4), which can act as a serine exopeptidase. ASide from there use in type 2 diabetes, gliptins have positive cardiovascular and anti-inflammtatory effects. Antidiabetic.<br>References Ahren, B., et al.: J. Clin. Endocrinol. Metab., 89, 2078 (2004), Ahren, B., et al.: Diabetes Care, 27, 2874 (2004), Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 5, 1094 (2004),<br></p>Fórmula:C17H25N3O2Cor e Forma:NeatPeso molecular:303.40Ranitidine Hydrochloride
CAS:<p>Stability Hygroscopic<br>Applications A histamine H2-receptor antagonist which inhibits gastric acid secretion. Antiulcerative.<br>References Bradshaw, J., et al.: Brit. J. Pharmacol., 66, 464 (1979), Berstad, A., et al.: Scand. J. Gastroenterol, 15, 637 (1980), Hohnjec, M., et al.: Anal. Profiles Drug Subs., 15, 533 (1986),<br></p>Fórmula:C13H22N4O3S·ClHCor e Forma:NeatPeso molecular:350.86Rafoxanide
CAS:<p>Applications Rafoxanide is a thyroid hormone receptor.<br>References Bernal, J., et al.: Vitam. Horm., 71, 95 (2005), Fujimoto, N., et al.: J. Endocrinol., 181, 77 (2005), Hamers, T., et al.: Toxicol. Sci., 92, 157 (2006), Jugan, M., et al.: Biochem. Pharmacol., 79, 939 (2010),<br></p>Fórmula:C19H11Cl2I2NO3Cor e Forma:WhitePeso molecular:626.01EPZ 6438
CAS:Produto Controlado<p>Applications EPZ 6438 is a potent and selective inhibitor of EZH2.<br>References Knutson, S., et al.: Nat. Chem. Biol., 8, 890 (2012)<br></p>Fórmula:C34H44N4O4Cor e Forma:NeatPeso molecular:572.742-[4-[2-(1-Piperidinyl)ethoxy]benzoyl]benzoic Acid
CAS:<p>Applications 2-[4-[2-(1-Piperidinyl)ethoxy]benzoyl]benzoic Acid is a research reagent with antispasmodic<br>References Bal-Tembe, S., et al.: Bioorg. Med. Chem., 5, 1381(1997);Punekar, N., et al.: Biotech. App. Biochem, 14, 378 (1991);<br></p>Fórmula:C21H23NO4Cor e Forma:NeatPeso molecular:353.414-(6,7-DIMETHOXY-QUINOLIN-4-YLOXY)-PHENYLAMINE
CAS:Pureza:95.0%Cor e Forma:Liquid, No data available.Peso molecular:296.32598876953125(2-CHLOROPYRIDIN-4-YL)(1H-PYRROLO[3,2-C]PYRIDIN-3-YL)METHANONE
CAS:Pureza:95.0%Peso molecular:257.679992675781252,3-Diphenyl-5-(thiophen-2-yl)-2H-tetrazol-3-ium chloride
CAS:Pureza:98%Peso molecular:340.82998657226564,5-Dichloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide
CAS:<p>Applications 4,5-Dichloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide is an impurity of Rivaroxaban (R538000), a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Fórmula:C19H17Cl2N3O5SCor e Forma:NeatPeso molecular:470.33ent-Rivaroxaban
CAS:<p>Applications ent-Rivaroxaban is the R-isomer of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Fórmula:C19H18ClN3O5SCor e Forma:White To Off-WhitePeso molecular:435.883-[1-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2,5-dimethyl-1H-pyrrol-3-yl]-3-oxopropanenitrile
CAS:Pureza:98%Peso molecular:348.406005859375ent-Valsartan
CAS:<p>Impurity Valsartan USP Related Compound A<br>Applications ent-Valsartan (Valsartan USP Related Compound A) is the (R)-enantiomer of Valsartan (V095750).<br>References Corea, L., et al.: Clin. Pharmacol. Ther., 60, 341 (1996), Satana, E;., et al.: J. Pharm. Biomed. Anal., 25, 1009 (2001), Sironi, L., et al.: Hypertension, 37, 961 (2001),<br></p>Fórmula:C24H29N5O3Cor e Forma:WhitePeso molecular:435.52O-Desisopropyl-O-methoxyethyl Nimodipine
CAS:Produto Controlado<p>Impurity Nimodipine EP Impurity C; Nimodipine USP Related Compound B<br>Applications O-Desisopropyl-O-methoxyethyl Nimodipine (Nimodipine EP Impurity C) is an impurity in the synthesis of Nimodipine (A dihydropyridine calcium channel blocker. It is used as a vasodilator (cerebral). Nimodipine USP Related Compound B.<br>References Allen, G.S., et al.: N. Engl. J. Med., 308, 619 (1983), Schluter, H.: Arzneim.-Forsch., 36, 1733 (1986), Deyo, R.A., et al.: Science, 243, 809 (1989),<br></p>Fórmula:C21H26N2O8Cor e Forma:NeatPeso molecular:434.441,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl Ester
CAS:<p>Impurity Nicardipine USP Related Compound A<br>Applications 1,4-Dihydropyridine derivative used in the prevention and therapy of atherosclerotic degradation of arterial walls. Nicardipine USP Related Compound A.<br>References Henry, P.D., et al.: Clin. Invest. Med., 10, 601 (1987), Weinstein, D.B., et al.: Am. J. Med., 86, 27 (1989), Gaviraghi, G., et al.: Pharmacol. Res., 31, 251 (1995),<br></p>Fórmula:C16H16N2O6Cor e Forma:Light YellowPeso molecular:332.312-Methyl-2-propyl-1,3-propanediol
CAS:Produto Controlado<p>Applications An intermediate in the synthesis of Carisoprodol.<br></p>Fórmula:C7H16O2Cor e Forma:NeatPeso molecular:132.20Latrepirdine dihydrochloride
CAS:<p>Latrepirdine dihydrochloride (Dimebolin dihydrochloride) is an orally active, and neuroactive antagonist of multiple drug targets.</p>Fórmula:C21H25N3·2HClPureza:98.45%Cor e Forma:SolidPeso molecular:392.37Riluzole-13C,15N2
CAS:Produto ControladoFórmula:C713CH5F315N2OSCor e Forma:Light Beige To Light YellowPeso molecular:237.186-Methoxy-2-naphthol
CAS:Produto Controlado<p>Stability Light Sensitive<br>Applications 6-Methoxy-2-naphthol is a reactant in the development of sirtuin inhibitors from pyrazolone and isoxazol-5-one cambinol analogs.<br>References Mahajan, S.S., et. al.: J. Med. Chem., 57, 3283 (2014)<br></p>Fórmula:C11H10O2Cor e Forma:NeatPeso molecular:174.20
![(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FD445748.webp&w=3840&q=75)
![(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FB680755.webp&w=3840&q=75)
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![2-[4-[2-(1-Piperidinyl)ethoxy]benzoyl]benzoic Acid](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FP482095.webp&w=3840&q=75)
![(2-CHLOROPYRIDIN-4-YL)(1H-PYRROLO[3,2-C]PYRIDIN-3-YL)METHANONE](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F10%2Fthumb-webp%2FF505769.webp&w=3840&q=75)
![4,5-Dichloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiopheneca…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FD435588.webp&w=3840&q=75)
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