Esteroides e Derivados
Os esteroides são compostos orgânicos que possuem uma estrutura de quatro anéis fundidos, conhecida como núcleo esteroide. Esse núcleo pode estar ligado a vários grupos funcionais que modificam suas propriedades e funções biológicas. Os esteroides desempenham um papel fundamental na regulação dos processos metabólicos e hormonais. São utilizados na medicina para tratar distúrbios inflamatórios, doenças autoimunes e desequilíbrios hormonais. Além disso, alguns derivados de esteroides possuem potentes propriedades anti-inflamatórias, como os corticosteroides. Em terapias específicas, são utilizados para reduzir a inflamação e controlar a dor em diversas doenças.
Na CymitQuimica, oferecemos uma variedade de esteroides e seus derivados para pesquisa e desenvolvimento farmacêutico.
Foram encontrados 4949 produtos de "Esteroides e Derivados"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
3-Oxo-4-aza-5a-androst-1-ene-17b-carboxylic acid
CAS:<p>3-Oxo-4-aza-5a-androst-1-ene-17b-carboxylic acid is a covalently bonded prodrug that is metabolized to its active form, finasteride, in the body. It has been shown to have physiological activities such as skin permeation and cell growth. 3-Oxo-4-aza-5a-androst-1-ene 17b carboxylic acid also has immunotherapy properties and can be conjugated with other compounds for use in cancer treatment.</p>Fórmula:C19H27NO3Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:317.42 g/molDefluoro atorvastatin calcium
CAS:<p>Defluoro atorvastatin calcium is a bulk drug that has been approved to be used as an adjunct to diet to reduce elevated cholesterol levels in adults. Defluoro atorvastatin calcium is the desfluoro-enantiomer of atorvastatin, which is a statin that inhibits the enzyme HMG-CoA reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonic acid, which is an early step in the synthesis of cholesterol. The fluoro group on defluoro atorvastatin calcium is not expected to have any significant effect on its potency or metabolic pathways and any impurities are not expected to have any therapeutic effect.</p>Fórmula:C66H70CaN4O10Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:1,119.36 g/molβ-Epoxyabiraterone acetate
CAS:<p>Beta-Epoxyabiraterone acetate is a synthetic and natural metabolite of abiraterone that is used as an API impurity in the synthesis of abiraterone acetate. The drug product is a niche compound with CAS No. 52464-96-6. The Metabolite is an impurity found in the synthesis of beta-epoxyabiraterone acetate. Drug development research and development, analytical methods, and pharmacopoeia are all involved in the production of this compound.</p>Fórmula:C26H33NO3Pureza:Min. 90 Area-%Cor e Forma:White Off-White PowderPeso molecular:407.55 g/mol(betaS,deltaS)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5- (1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole- 1-heptanoic acid calcium salt (2:1)
CAS:<p>(betaS,deltaS)-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole- 1-heptanoic acid calcium salt (2:1) is a fluorinated derivative of the natural metabolite 2-(4-fluorophenyl)-beta,delta-dihydroxy -5-(1 methylethyl)-3 phenyl 4-[(phenylamino)carbonyl]-1H pyrrole 1 heptanoic acid. It is an enantiomer of the racemate with optical purity > 98%. The compound has been used as a pharmacological and supramolecular chemistry probe for assays and chemosensors.</p>Fórmula:C66H68CaF2N4O10Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:1,155.34 g/mol(3R,5S)-Atorvastatin sodium salt
CAS:<p>(3R,5S)-Atorvastatin sodium salt is a synthetic compound that is used in the treatment of high cholesterol. It belongs to the class of statins, which are used for lowering blood cholesterol levels. The drug product contains at least 99% by weight of (3R,5S)-atorvastatin sodium salt. This product also has an analytical purity greater than 98%. It is metabolized via oxidation and hydroxylation to form metabolites that exhibit pharmacological activity similar to the parent molecule. (3R,5S)-Atorvastatin sodium salt is a natural product that can be found in plants such as yew trees. This drug has been shown to have niche applications in drug development and research and development.</p>Fórmula:C33H34FN2NaO5Pureza:Min. 95%Cor e Forma:PowderPeso molecular:580.62 g/molAtorvastatin epoxy pyrrolooxazin tricyclic impurity
<p>Atorvastatin is a drug product that is metabolized to atorvastatin epoxy pyrrolooxazin tricyclic impurity. Due to the presence of this impurity, the purity of the drug product is not 100%. Atorvastatin epoxy pyrrolooxazin tricyclic impurity is a natural metabolite with CAS number 516-80-1. It has been shown to have effects on metabolism and may be involved in the development of atherosclerosis. Metabolism studies have been conducted on animals, but not humans.</p>Fórmula:C33H32FN2NaO6Pureza:Min. 95%Peso molecular:594.61 g/molCalcipotriol EP impurity E
<p>Calcipotriol EP Impurity E is a synthetic impurity that is found in the calcipotriol EP API. Calcipotriol EP Impurity E is an impurity standard for HPLC and can be used in drug development, research and development, and pharmacopoeia. It has been shown to have no significant effect on the pharmacological activity of calcipotriol EP.</p>Fórmula:C27H42O3Pureza:Min. 95 Area-%Cor e Forma:PowderPeso molecular:414.62 g/molDutasteride impurity F
CAS:<p>Dutasteride impurity D is a natural impurity found in dutasteride and has been reported to be an analytical marker for dutasteride. It is also used as an impurity standard, HPLC standard, and custom synthesis for drug development. Metabolism studies have shown that the major route of elimination for Dutasteride impurity D is through glucuronidation with minor amounts being excreted in urine unchanged.</p>Fórmula:C27H31ClF6N2O2Pureza:Min. 95 Area-%Peso molecular:564.99 g/mol(R)-4-((5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
CAS:Pureza:95%Peso molecular:392.58Atorvastatin
CAS:<p>Orally active atorvastatin inhibits HMG-CoA reductase, lowers lipids, hinders SV-SMC cell growth, and can up thrombotic risk with clopidogrel.</p>Fórmula:C33H35FN2O5Pureza:99.37% - 99.69%Cor e Forma:SolidPeso molecular:558.64Bexarotene
CAS:<p>Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).</p>Fórmula:C24H28O2Pureza:99% - 99.65%Cor e Forma:White SolidPeso molecular:348.48Travoprost
CAS:<p>Travoprost (Fluprostenol isopropyl ester) is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist.</p>Fórmula:C26H35F3O6Pureza:97.39% - 99.58%Cor e Forma:Colorless OilPeso molecular:500.55∆9,11-Dehydro-17α-cyanomethyl Estradiol
CAS:Produto Controlado<p>Applications ∆9,11-Dehydro-17α-cyanomethyl estradiol is a metabolite of progestin dienogest (D441870), and is currently being investigated for progesterone-receptor binding, progestational, antiprogestational, estrogenic and antigonadotropic activities for the inhibition of fertility. It is also being considered a novel treatment for heavy menstrual bleeding.<br>References Oettel, M., et al.: Pharmazie, 41, 627 (1993); Kiley, J. & Shulman, L.: Int. J. Womens Health, 3, 281 (2011);<br></p>Fórmula:C20H23NO2Cor e Forma:NeatPeso molecular:309.40(4S,cis)-1,1-Dimethylethyl-6-aminoethyl-2,2-dimethyl-1,3-dioxane-4-acetate
CAS:Produto Controlado<p>Applications An impurity of Atorvastatin.<br>References Graul, A., et al.: Drugs Fut. 22, 956 (1997),<br></p>Fórmula:C14H27NO4Cor e Forma:NeatPeso molecular:273.37(3aR,4R,5R,6aS)-Hexahydro-4-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]-2-oxo-2H-cyclopenta[b]furan-5-yl Ester [1,1'-Biphenyl]-4-carboxylic Acid
CAS:<p>Applications Latanoprost Enol is an impurity of Latanoprost (L177280), a prostaglandin analogue used to treat glaucoma and other degenerative diseases of the eye.<br>References Resul, B., et al.: J. Med. Chem., 36, 2242 (1993);<br></p>Fórmula:C31H30O5Cor e Forma:NeatPeso molecular:482.5721-Carboxy Dexamethasone
CAS:<p>Applications 21-Carboxy Dexamethasone is a useful research chemical.<br>References Shepard, Allan R., ACS Chem. Biol., 3, 549-558(2013);<br></p>Fórmula:C22H27FO6Cor e Forma:White To Off-WhitePeso molecular:406.4413-Ethyl-3-ethynyl-18,19-dinor-17α-pregna-3,5-dien-20-yn-17-ol(Levo Norgestrel Impurity)
CAS:Produto Controlado<p>Impurity Levonorgestrel EP Impurity C<br>Applications 13-Ethyl-3-ethynyl-18,19-dinor-17α-pregna-3,5-dien-20-yn-17-ol (Levonorgestrel EP Impurity C) is an impurity of Levonorgestrel.<br></p>Fórmula:C23H28OCor e Forma:NeatPeso molecular:320.47Vitamin D3 b-D-Glucuronide, >90%
CAS:Produto Controlado<p>Stability Temperature and Light Sensitive<br>Applications A metabolite of Vitamin D3.<br>References Bell, P.A., et al.: Biochem. J., et al.: 115, 663 (1969), Kumar, R.S., et al.: J. Clin. Invest., 65, 277 (1980), Shimada, K., et al.: Biol. Pharm. Bull., 19, 491 (1996),<br></p>Fórmula:C33H52O7Pureza:>90%Cor e Forma:NeatPeso molecular:560.76Exemestane-13C,D3
CAS:Produto Controlado<p>Applications Exemestane-13C,D3 is the labeled analogue of Exemestane (E957000), an antineoplastic (hormonal).<br>References Giudici, D., et al.: J. Steroid Biochem., 30, 391 (1988), Evans, T.R.J., et al.: Cancer Res., 52, 5933 (1992), Zilembo, N., et al.: Brit. J. Cancer, 72, 1007 (1995)<br></p>Fórmula:C1913CH21D3O2Cor e Forma:NeatPeso molecular:300.41(16α)-16-Methyl-17,20:20,21-bis[methylenebis(oxy)]-pregna-1,4-diene-3,11-dione
CAS:Produto ControladoFórmula:C24H30O6Cor e Forma:NeatPeso molecular:414.49rac 7-Methoxy Lasofoxifene
CAS:Produto Controlado<p>Applications Lasofoxifene intermediate.<br>References Rosati, R., et al.: J. Med. Chem., 41, 2928 (1998),<br></p>Fórmula:C29H33NO2Cor e Forma:NeatPeso molecular:427.58Estriol 16a,17b-Diacetate
CAS:Produto Controlado<p>Applications Estriol 16α,17β-Diacetate is a diacetate derivative of Estriol (E888960); an estrogenic metabolite considerably less potent than the hormone Estradiol (E888000).<br>References Marrian, et al.: Biochem. J., 23,1090 (1929); Huffman, et al.: J. Biol. Chem., 169, 167 (1947)<br></p>Fórmula:C22H28O5Cor e Forma:NeatPeso molecular:372.4516-Methyl-17,20:20,21-bis[methylenebis(oxy)]-pregn-4-ene-3,11-dione
CAS:Produto ControladoFórmula:C24H32O6Cor e Forma:NeatPeso molecular:416.51(3aR,4R,5R,6aS)-4-Formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate
CAS:Produto Controlado<p>Applications (3aR,4R,5R,6aS)-4-Formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate is an intermediate in the synthesis of Prostaglandin E2 (P838610), the most common and biologically potent of mammalian prostaglandins.<br>References Radeuchel, B., et al.: Tetrahedron. Lett., 633, 9 (1975);<br></p>Fórmula:C21H18O5Cor e Forma:NeatPeso molecular:350.36463-Oxo-4-aza-5a-androst-1-ene-17b-carboxylic Acid Methyl Ester
CAS:Produto Controlado<p>Impurity Finasteride EP Impurity B<br>Applications 3-Oxo-4-aza-5α-αndrost-1-ene-17β-carboxylic Acid Methyl Ester (Finasteride EP Impurity B) is an impurity of Finasteride (F342000) and Dutasteride (D735000). An intermediate in the synthesis of Finasteride and Dutasteride, 5α-reductase inhibitors used for treatment of benign prostatic hyperplasia acne, seborrhea, female hirsutism, prostatitis, and prostatic carcinoma and other hyperandrogenetic related disorders. Finasteride impurity.<br>References Bakshi., et al.: J. Med. Chem., 38, 3189 (1995),<br></p>Fórmula:C20H29NO3Cor e Forma:White To Off-WhitePeso molecular:331.45(5E)-Calcipotriene
CAS:Produto Controlado<p>Impurity Calcipotriol EP Impurity C<br>Stability Temperature Sensitive<br>Applications The trans-isomeric impurity of Calcipotriene (C144200) and a vitamin D3 analogue with antitumor effects.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wietrzyk, J. et al.: Anti-Cancer Drugs, 18, 447 (2007); Wietrzyk, J. et al.: Anticancer Res., 27, 3387 (2007); Filip, B. et al.: J. Ster. Biochem. Mol. Biol., 121, 399 (2010);<br></p>Fórmula:C27H40O3Cor e Forma:NeatPeso molecular:412.60Ciclesonide-d11 (Mixture of Diastereomers)
CAS:Produto Controlado<p>Applications A labelled glucocorticoid microemulsion nasal preparation allergy inhibitor rhinitis.This compound is a mixture of diastereomers at the cyclohexyl acetal.<br>References Fukuoka, E., et al.: Chem. Pharm. Bull., 35, 2943 (1987), Schmitt, E., et al.: J. Pharm. Sci., 88, 291 (1999), Hancock, B., et al.: Pharm. Res., 17, 397 (2000), Hogan, S., et al.: Pharm. Res., 18, 112 (2001).<br></p>Fórmula:C32D11H33O7Cor e Forma:NeatPeso molecular:551.7611β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione-d3
Produto Controlado<p>Applications A labelled metabolite of Budesonide (B689490), an antiinflammatory agent.<br>References Cserhati, T., et al.: J. Pharm. Biomed. Anal., 22, 25 (2000), Dilger, K., et al.: J. Clin. Pharmacol., 47, 1532 (2007), Buchwald, P., et al.: Steroids, 73, 193 (2008),<br></p>Fórmula:C21H25D3O6Cor e Forma:NeatPeso molecular:379.46Estradiol 3-Valerate
CAS:Produto Controlado<p>Applications Estradiols ester used in polymeric matrix for transdermal treatment of osteoporosis.<br>References Tripathi, V.N., et al.: Can. J. Animal Sci., 48, 449 (1968),<br></p>Fórmula:C23H32O3Cor e Forma:NeatPeso molecular:356.516a-Hydroxy Levonorgestrel
CAS:<p>Impurity Levonorgestrel EP Impurity G<br>Applications 6α-Hydroxy Levonorgestrel (Levonorgestrel EP Impurity G) is a hydroxylated impurity of Norgestrel (N689500).<br>References Lin, Y., et al.: Biochim. Biophys. Acta, 218, 526 (1970), Smith, K., et al.: J. Steroid Biochem., 32, 445 (1989), Hu, S., et al.: Steroids, 60, 337 (1995),<br></p>Fórmula:C21H28O3Cor e Forma:White SolidPeso molecular:328.44Dexamethasone acetate monohydrate
CAS:<p>Dexamethasone acetate treats rheumatic issues, skin conditions, asthma, allergies, COPD, brain swelling, croup, TB adjunct.</p>Fórmula:C24H33FO7Cor e Forma:SolidPeso molecular:452.523-(N-Phenyl-N-methyl)aminoacrolein
CAS:<p>3-(N-Phenyl-N-methyl)aminoacrolein is a hydrophobic compound that has been shown to reversibly bind to serum albumin. This binding leads to a decrease in the lipid content of lipoproteins and a decrease in the rate of their metabolism. These effects are mediated by hydrophobic interactions with the hydrophobic regions of serum albumin. 3-(N-Phenyl-N-methyl)aminoacrolein also interacts with human serum albumin, which is involved in lipid transport and metabolism, and can be used as a contrast agent for X-ray diffraction studies.</p>Fórmula:C10H11NOPureza:Min. 97 Area-%Cor e Forma:PowderPeso molecular:161.2 g/mol(4R)-4-[(1S,2S,5R,7R,10R,11S,14R,15R,16S)-5,16-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]pentanoic acid
CAS:Fórmula:C24H40O4Pureza:98%Cor e Forma:SolidPeso molecular:392.58[1S-(1α,3aBeta,4β,7aAlpha)]-4-[2-(2,5-Dihydroxyphenyl)ethyl]octahydro-1-hydroxy-7a-methyl-5H-inden-5-one
CAS:Produto ControladoFórmula:C18H24O4Cor e Forma:NeatPeso molecular:304.389α-Bromobudesonide
CAS:Produto Controlado<p>Impurity Budesonide EP Impurity J<br>Applications 9α-Bromobudesonide (Budesonide EP Impurity J) is an impurity of Budesonide (B689460), a non-halogenated glucocorticoid intended for the local treatment of lung disease.<br>References Ryrfeldt, Å., et al.: Eur. J. Respir. Dis., 122, 86 (1981); Vestbo, J., et al.: Lancet, 353, 1819 (1999)<br></p>Fórmula:C25H33BrO6Cor e Forma:NeatPeso molecular:509.43Dexamethasone Oxetanone
CAS:Produto Controlado<p>Applications Dexamethasone Oxetanone is a potent antiglucocorticoid.<br>References Lamontagne, N., et al.: Endocrinology, 114, 2252 (1984);<br></p>Fórmula:C22H27FO4Cor e Forma:NeatPeso molecular:374.4518-Methyl Mestranol
CAS:Produto Controlado<p>Applications Mestranol (M258755) derivative. It is used as contraceptive.<br>References Cullen, L.F., et al.: J. Pharma. Sci., 57, 1857 (1968),<br></p>Fórmula:C22H28O2Cor e Forma:NeatPeso molecular:324.464β-Hydroxy Cholesterol
CAS:Produto Controlado<p>Applications A metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker.<br>References Breuer, O., et al.: J. Lipid Res., 36, 2275 (1995), Pikuleva, I., et al.: J. Biol. Chem., 273, 18153 (1998), Chawla, A., et al.: Science, 294, 1866 (2001), Bodin, K., et al.: J. Biol. Chem., 276, 38685 (2001),<br></p>Fórmula:C27H46O2Cor e Forma:White To Light BeigePeso molecular:402.651,2-Dihydro Triamcinolone
CAS:Produto Controlado<p>Applications 1,2-Dihydro Triamcinolone is a derivative of Triamcinolone (T767165), a glucocorticoid, antiasthmatic (inhalant); antiallergic (nasal).<br>References Florey, K., et al.: Anal. Profiles Drug Subs., 1, 397 (1972); Bernstein, I.L., et al.: Chest, 81, 20 (1982);<br></p>Fórmula:C21H29FO6Cor e Forma:NeatPeso molecular:396.45Dexamethasone 17-Propionate
CAS:Produto Controlado<p>Applications A Dexamethasone Dipropionate metabolite.<br>References Miyachi, Y., et al.: Steroids, 52, 137 (1988), Soh H., et al.: Brit. J. dermatol., 125, 73 (1991), Civiale, C., et al.: J. Ocul. Pharmacol., Thera., 20, 75 (2004),<br></p>Fórmula:C25H33FO6Cor e Forma:NeatPeso molecular:448.5217α-Hydroxyprogesterone Valerate
CAS:Produto Controlado<p>Applications 17α-Hydroxy-progesterone Valerate acts as a synthetic Progesterone (P755900) reducing the chance of pre-term birth in women. Progesterone is a steroid hormone produced by the corpus luteum. Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation<br>References Anderson, E., et al.: Breast Cancer Res., 4, 197 (2002), Lanari, C., et al.: Breast Cancer Res., 4, 240 (2002), Albrecht, E.D., et al.: Front. Biosci., 8, 416 (2003), Qiu, M., et al.: J. Steroid Biochem. Mol. Biol., 85, 147 (2003),<br></p>Fórmula:C26H38O4Cor e Forma:NeatPeso molecular:414.58Estradiol 17-Valerate-d9
CAS:Produto Controlado<p>Applications Labelled Estradiol (E888000) derivative. An estrogen.<br>References Salole, E.G., et al.: Anal. Profiles Drug Subs., 15, 283 (1986), Lievertz, R.W., et al.: Am. J. Obstet. Gynecol., 156, 1289 (1987),<br></p>Fórmula:C23H23D9O3Cor e Forma:NeatPeso molecular:365.55(E/Z)-17-Deacetylnorgestimate
CAS:Produto ControladoFórmula:C21H29NO2Cor e Forma:NeatPeso molecular:327.46δ6-Gestodene
Produto Controlado<p>Applications Δ6-Gestodene, is an impurity of Gestodene (G368250), an orally active gestogen with progesterone-like profile of activity. Used in combination with estrogen as oral contraceptive.<br>References Duesterberg, B., et al.: Contraception, 24, 673 (1981); Duesterberg, B., et al.: Seroids, 43, 43 (1984); Losert, W., et al.: Arzneim.-Forsch., 35, 459 (1985);<br></p>Fórmula:C21H24O2Cor e Forma:NeatPeso molecular:308.41(6α,9β,11β,16α)-21-(Acetyloxy)-9,11-epoxy-6-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,20-dione
CAS:Produto Controlado<p>Applications (6α,9β,11β,16α)-21-(Acetyloxy)-9,11-epoxy-6-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,20-dione is an intermediate in the synthesis of Paramethasone Acetate (P191845), a derivative of Dexamethasone (D298800), a potent synthetic member of the glucocorticoid class of steroid drugs that has anti-inflammatory and immunosuppressant properties.<br>References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995), Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999), Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)<br></p>Fórmula:C24H29FO6Cor e Forma:Off-WhitePeso molecular:432.48Mexrenone
CAS:Produto Controlado<p>Applications Mexrenone is an impurity of eplerenon (E588775). Eplerenone is a selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.<br>References de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987), Delyani, J.A., et al.: Cardiovasc. Drug Rev., 19, 185 (2001), Burgess, E., et al.: Expert. Opin. Pharmacother., 5, 2573 (2004), Ravis, W.R., et al.: J. Clin. Pharmacol., 45, 810 (2005),<br></p>Fórmula:C24H32O5Cor e Forma:Off-WhitePeso molecular:400.50793-Aminobenzotrifluoride
CAS:Produto Controlado<p>Applications 3-Aminobenzotrifluoride is a known human toxin that can cause bacterial mutation and hepatocyte unscheduled DNA synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Reinhold, D., et al.: T. ASAE, 49, 2077 (2006); Thompson, C., et al.: Environ. Mutagen., 5, 803 (1983)<br></p>Fórmula:C7H6F3NCor e Forma:YellowPeso molecular:161.12Cortisol-D4 21-Sulfate Potassium Salt
CAS:Produto Controlado<p>Applications Labelled Cortisol-d4 21-Sulfate (C696320). Cortisol 21-Sulfate is a phase II metabolite of Cortisol (H714615).<br>References Spielgelhalder, B., et al.: J. Steroid Biochem., 7, 749 (1976), Vanluchene, E., et al.: J. Chromatogr., 456, 175 (1988), Choi, M., et al.: Steroids, 65, 54 (2000),<br></p>Fórmula:C21H25D4KO8SCor e Forma:NeatPeso molecular:484.64Testosterone-d8
CAS:Produto Controlado<p>Applications Labelled Testosterone (T155000). Principal hormone of the testes, produced by the interstitial cells. Major circulating androgen; converted by 5α-reductase in androgen-dependent target tissues to 5α-dehydrotestosterone which is required for normal male sexual differentiation. Also converted by aromatization to Estradiol.Controlled substance (anabolic steroid). Androgen.<br>References McFarland, K., et al.: Science, 245, 494 (1989), Heckert, L., et al.: Mol. Endocrinol., 12, 1499 (1998), Themmen, A., et al.: Endocr. Rev. 21, 551 (2000), Kumar, R., et al.: Biol. Reprod., 65, 710 (2001),<br></p>Fórmula:C19H20D8O2Cor e Forma:White To Off-WhitePeso molecular:296.4721-Butyryloxy Budesonide
<p>Applications 21-Butyryloxy Budesonide is a derivative of Budesonide (B689490), a non-halogenated glucocorticoid related to triamcinolone hexacetonide.<br>References Ryrfeldt., A., et a.: J. Steroid Biochem., 10, 317 (1979); Roth, G., et al.: J. Pharm. Sci., 69, 766 (1980); Clissold, S.P., et al.: Drugs, 28, 485 (1984)<br></p>Fórmula:C29H40O7Cor e Forma:NeatPeso molecular:500.62(11β)-9-Fluoro-11,21-dihydroxy-16-methyl-pregna-1,4,16-triene-3,20-dione
CAS:Produto Controlado<p>Applications (11β)-9-Fluoro-11,21-dihydroxy-16-methyl-pregna-1,4,16-triene-3,20-dione is a derivative of Dexamethasone (D298800), an anti-inflammatory glucocorticoid.<br>References Kodelja, V., et al.: J. Immunol., 160, 1411 (1998), Metselaar, J., et al.: Arthritis Rheum., 48, 2059 (2003), Buttgereit, F., et al.: Arthritis Rheum., 50, 3408 (2004), Martinez, F., et al.: Front Biosci., 13, 453 (2008),<br></p>Fórmula:C22H27FO4Cor e Forma:WhitePeso molecular:374.45a,a,a-Trifluorotoluene
CAS:Produto Controlado<p>Applications α,α,α-Trifluorotoluene, is used as a specialty solvent in organic synthesis and an intermediate in the production of pesticides and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Skelly, P. D., et al.: Handbook for Critical Cleaning, 1, 191 (2011);<br></p>Fórmula:C7H5F3Cor e Forma:ColourlessPeso molecular:146.1111b-Hydroxy Etiocholanolone
CAS:Produto Controlado<p>Applications A metabolite of Etiocholanolone.<br>References Eriksson, H., et al.: Eur. J. Biochem., 15, 132 (1970), Cook, D., et al.: Endocrinology, 93, 1019 (1973),<br></p>Fórmula:C19H30O3Cor e Forma:White To Off-WhitePeso molecular:306.4417α-Hydroxyprogesterone Heptanoate
CAS:<p>Applications 17α-Hydroxyprogesterone Heptanoate can be used in therapeutic use and biological study of pharmaceutical compounds and methods of use thereof for treating gender-biased immune disorders.<br>References Stoloff, G., et al.: PCT Int. Appl. WO 2016005599 A1 20160114 (2016)<br></p>Fórmula:C28H42O4Cor e Forma:NeatPeso molecular:442.63Desisobutyryl Ciclesonide
CAS:Produto Controlado<p>Applications Preclinical profile of Ciclesonide, a novel corticosteroid for the treatment of asthma.<br>References Austin, R., et al.: Eur. Respir. J., 20, 1386 (2002), Belvisi, M.G., et al.: J. Pharmacol. Exp. Ther., 314, 568 (2005), Richter, K., et al.: J. Clin. Pharmacol., 45, 146 ( 2005).<br></p>Fórmula:C28H38O6Cor e Forma:White To Off-WhitePeso molecular:470.6013-Ethyl-18,19-dinor-17α-pregn-4-en-20-yn-17-ol (~90%) (Levo Norgestrel Impurity)
CAS:Produto Controlado<p>Impurity Levonorgestrel EP Impurity D<br>Applications 13-Ethyl-18,19-dinor-17α-pregn-4-en-20-yn-17-ol (Levonorgestrel EP Impurity D) is an impurity of Levonorgestrel.<br>References McGinty, D., et al.: Endocrinology, 24, 829 (1939), Belanger, A., et al.: Steroids, 37, 361 (1981), Nieman, L., et al.: J. Clin. Endocrinol. Metab., 61, 536 (1985), Klebe, G., et al.: J. Med. Chem., 37, 4130 (1994),<br></p>Fórmula:C21H30OCor e Forma:NeatPeso molecular:298.464-Hydroxy Estradiol 1-N3-Adenine
CAS:Produto Controlado<p>Applications 4-Hydroxy Estradiol 1-N3-Adenine is an estrogen metabolite formed with DNA which can lead to the mutations that initiate breast, prostate, and other types of cancer. The N3Ade depurinating adducts could serve as biomarkers to predict the risk of breast cancer.<br>References Chakravarti, D., et al.: Mutat. Res., 456, 17 (2000), Liehr, J., et al.: Endocr. Rev., 21, 4054 (2000), Chakravarti, D., et al.: Oncogene, 20, 7945 (2001), Cavalieri, E., et al.: Chem. Res. Toxicol., 14, 1041 (2002),<br></p>Fórmula:C23H27N5O3Cor e Forma:NeatPeso molecular:421.49Epoxy Metradiene
CAS:Produto Controlado<p>Applications Epoxy Metradiene is an impurity from synthesis of Fluorometholone (F593145),a glucocorticoid; anti-inflammatory.<br>References Kupferman, A., et al.: Arch. Ophthlmol., 640, 100 (1982); Tokunaga H., et al.: Chem. Pharm. Bull., 32, 4012 (1984);<br></p>Fórmula:C22H28O4Cor e Forma:NeatPeso molecular:356.4620-Dihydroprogesterone Acetate
CAS:Produto Controlado<p>Impurity Progesterone EP Impurity E<br>Applications 20-Dihydroprogesterone Acetate (Progesterone EP Impurity E) is an analogue of Progesterone (P755900), a steroid used in cardiovascular and menopausal studies.<br>References Grodstein, F. et al.: New. Eng. J. Med., 335, 453 (1996); Cushman, M. et al.: Circulation, 100, 717 (1999);<br></p>Fórmula:C23H34O3Cor e Forma:NeatPeso molecular:358.51Estriol 3,16a,17b-Triacetate
CAS:Produto Controlado<p>Applications Estriol 3,16α,17β-Triacetate is a triacetate derivative of Estriol (E888960) with contraceptive activity.<br>References Wotiz, H.H., et al.: J. Reprod. Fertil., 26, 363 (1971)<br></p>Fórmula:C24H30O6Cor e Forma:NeatPeso molecular:414.494'-Nitro-3'-(trifluoromethyl)acetanilide
CAS:<p>Applications 4’-Nitro-3’-(trifluoromethyl)acetanilide is a metabolite of the nonsteroidal antiandrogen drug, Flutamide (F598850).<br>References Kang, P. et al.: Drug Metab. Dispos., 36, 1425 (2008); Takashima, E. et al.: Biol. Pharmac. Bull., 26, 1455 (2003); Katchen, B. et al.: J. Invest. Dermatol., 66, 379 (1976);<br></p>Fórmula:C9H7F3N2O3Cor e Forma:NeatPeso molecular:248.16Betamethasone 21-Mesylate (>90%)
CAS:Produto ControladoFórmula:C23H31FO7SPureza:>90%Cor e Forma:NeatPeso molecular:470.5513β-Ethyl-11-methylenegon-4-en-17-one
CAS:Produto Controlado<p>Applications Desogestrel intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bergink, E., et al.: J. Steroid Biochem., 14, 175 (1981), Phillips, A., et al.: Contraception, 36, 181 (1987)<br></p>Fórmula:C20H28OCor e Forma:NeatPeso molecular:284.44Betamethasone 21-Phosphate Biotin (>85%)
Produto ControladoFórmula:C34H49FN3O10PSPureza:>85%Cor e Forma:NeatPeso molecular:741.816-Oxo Boldione
CAS:Produto Controlado<p>Applications A derivative of Exemestane (E957000), a new aromatase inhibitor.<br>References Thompson, E., et al.: J. Biol. Chem., 249, 5364 (1974), Cole, P., et al.: J. Med. Chem., 33, 2933 (1990), Buzzetti, F., et al.: Steroids, 58, 527 (1993),<br></p>Fórmula:C19H22O3Cor e Forma:Off-White To Light YellowPeso molecular:298.38(11β,16α)-9-Bromo-21-[(ethoxycarbonyl)oxy]-11-(formyloxy)-17-hydroxy-16-methylpregna-1,4-diene-3,20-dione
CAS:Produto Controlado<p>Stability Moisture Sensitive<br>Applications (11β,16α)-9-Bromo-21-[(ethoxycarbonyl)oxy]-11-(formyloxy)-17-hydroxy-16-methylpregna-1,4-diene-3,20-dione is an impurity of Dexamethasone (D298800), a glucocorticoid used as an anti-inflammatory agent.<br>References Spangler, M., et al.: Chromatographia, 54(5/6), 329-334 (2001);Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995)<br></p>Fórmula:C26H33BrO8Cor e Forma:NeatPeso molecular:553.443β,5α-Tetrahydrodeoxycorticosterone
CAS:<p>Applications 3β,5α-Tetrahydrodeoxycorticosterone is a novel derivative of the steroid Dehydroepiandrosterone (DHEA), a known uncompetitive inhibitor of Glucose 6-Phosphate Dehydrogenase (G6PD). Studies have shown that 3β,5α-Tetrahydrodeoxycorticosterone may have potential function in the modulation of calcium and GABAA-gated chloride channel currents found in rat and guinea-pig neurons.<br>References Hamilton, N.M., et al.: J. Medn. Chem., 55, 4431 (2012); Ffench, M., et al.: Steriods., 64, 76 (1999);<br></p>Fórmula:C21H34O3Cor e Forma:White To Off-WhitePeso molecular:334.49(11β,16β)-11,21-bis(acetyloxy)-2'-methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione(Deflazacort Impurity)
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications (11β,16β)-11,21-bis(acetyloxy)-2'-methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione, is an impurity of Deflazacort, which is a systemic corticosteroid, used for rheumatoid arthritis and lupus.<br>References Nathansohn, G., et al.: J. Med. Chem., 10,799 (1967), Schiatti, P., et al.: Arzneim. Forsch., 30, 1543 (1980), Cavall-Perin, P., et al.: Eur. J. Clin. Pharmacol., 26, 357 (1984), Imbimbo, B., et al.: Adv. Exp. Med. Biol., 171, 241 (1984),<br></p>Fórmula:C27H33NO7Cor e Forma:NeatPeso molecular:483.553-Oxo-4-aza-5-androstene-17β-carboxylic Acid
CAS:Produto ControladoFórmula:C19H27NO3Cor e Forma:NeatPeso molecular:317.4223-Hydroxybudesonide
CAS:Produto Controlado<p>Applications 23-Hydroxybudesonide is an metabolite of budesonide (B689490), a non-halogenated glucocorticoid related to triamcinolone hexacetonide. Used as an antiinflammatory agent.<br>References Edsbaecker, S., et al.: Drug. Metabol. Dispostion., 15, 403 (1987); Moore, C.D., et al.: Drug. Metabolism. Disposition., 41, 379 (2013);<br></p>Fórmula:C25H34O7Cor e Forma:NeatPeso molecular:446.539-Dehydroestrone
CAS:Produto ControladoFórmula:C18H20O2Cor e Forma:White To Off-WhitePeso molecular:268.35(3(α))-Allopregnanolone 3-(β)-DGlucuronide
CAS:Produto Controlado<p>Applications (3α)-Allopregnanolone 3-β-D-Glucuronide is the glucuronide conjugate of (3α)-Allopregnanolone (A547100), metabolite of progesterone and potent positive modulator of GABAA receptors.<br>References Martin, F. et al.: LJ Steroid Biochem., 6, 1339 (1975); Lin, M.T. et al.: Steroids, 32, 547 (1978);<br></p>Fórmula:C27H42O8Cor e Forma:NeatPeso molecular:494.6218-Methyl Ethynyl Estradiol
CAS:Produto ControladoFórmula:C21H26O2Cor e Forma:NeatPeso molecular:310.4299Fluocinolone Acetonide-13C3
CAS:Produto ControladoFórmula:C2113C3H30F2O6Cor e Forma:NeatPeso molecular:455.47Testosterone-16,16,17-d3 17-Decanoate
CAS:Produto Controlado<p>Applications Testosterone 17-Decanoate-d3, is the labeled analogue of Testosterone 17-Decanoate (T155120), an ester of Testosterone (T155000). Testosterone 17-Decanoate, can be used as a potential long-acting male contraceptive, with the combination of subcutaneous etonogestrel implants.<br>References Brady, B. M., et al.: Human Reproduction, 21 (1), 285 (2006); Themmen, A., et al.: Endocr. Rev. 21, 551 (2000);<br></p>Fórmula:C292H3H43O3Cor e Forma:NeatPeso molecular:445.69Boldione (1 mg/ml in Acetonitrile)
CAS:Produto ControladoFórmula:C19H24O2Cor e Forma:Single SolutionPeso molecular:284.396-Deschloro Cyproterone Acetate
CAS:Produto Controlado<p>(1β,2β)-17-(Acetyloxy)-1,2-dihydro-3'H-cyclopropa[1,2]pregna<br>-1,4,6-triene-3,20-dione; 17-Hydroxy-1 ,2 -methylenepregna<br>-4,6-diene-3,20-dione Acetate; Cyproterone Acetate EP<br>Impurity A<br></p>Fórmula:C24H30O4Cor e Forma:NeatPeso molecular:382.493Testosterone (1mg/ml in Acetonitrile)
CAS:Produto ControladoFórmula:C19H28O2Cor e Forma:ColourlessPeso molecular:288.426β,17α-Dihydroxyprogesterone
CAS:Produto ControladoFórmula:C21H30O4Cor e Forma:NeatPeso molecular:346.466β-Hydroxymethylandrosta-1,4-diene-3,17-dione
CAS:Produto ControladoFórmula:C20H26O3Cor e Forma:White To Off-WhitePeso molecular:314.422,2-Dibromo-1-(4-fluorophenyl)-2-phenylethanone
Produto ControladoFórmula:C14H9Br2FOCor e Forma:NeatPeso molecular:372.03Deflazacort-d3 (Major)
CAS:Produto ControladoFórmula:C25H28D3NO6Cor e Forma:NeatPeso molecular:444.5425-Hydroxy Cholesterol-d6
CAS:Produto Controlado<p>Applications 25-Hydroxy Cholesterol-d6, is the labeled analogue of 25-Hydroxy Cholesterol (H918030), which is an oxygenated derivative of Cholesterol (C432501); an oxysterol. An inhibitor of human immunodeficiency virus replication in vitro. It also induces apoptosis in human monocytic cell lines as well as inducing apoptosis in CEM cells associated with negative regulation of c-Myc.<br>References Aupeix, K. et al.: Immunobiology, 194, 415 (1995); Moog, C. et al.: Antivir. Chem, Chemother., 9, 491 (1998); Ayala-Torres, S. et al.: Exp. Cell Res., 246, 193 (1999);<br></p>Fórmula:C272H6H40O2Cor e Forma:NeatPeso molecular:408.69Atorvastatin-d5 tert-Butyl Ester
CAS:Produto Controlado<p>Applications Atorvastatin-d5 tert-Butyl Ester is the labeled analogue of Atorvastatin tert-Butyl Ester (A791740), an impurity arising in the synthesis of Atorvastatin (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.<br>References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996); Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)<br></p>Fórmula:C37H38D5FN2O5Cor e Forma:NeatPeso molecular:619.786a-9-Difluoroprednisolone-17-Carboxylate
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications 6α-9-Difluoroprednisolone-17-Carboxylate is an impurity of 6α,9α-Difluoroprednisolone (D446290), shown to increase metastases and increase glucocorticoid activity in C57/BL6 mice.<br>References Albert, D., Zeidman, I.: Cancer Res., 22, 1297 (1962)<br></p>Fórmula:C20H24F2O5Cor e Forma:NeatPeso molecular:382.4(3E)-17-Deacetylnorgestimate
CAS:<p>Applications E-17-Deacetylnorgestimate is a metabolite of Norgestimate. A contraceptive for birth control used by women.Note- The oxime isomerizes when: 1) Heated in any solvent or heating the crystalline form 2) Dissolved in MeOH at room temperature very quickly 3) Dissolved in acetone or CHCl3 at room temperature in a couple of hours at room temperature4) In EtOAc or EtOAc/isooctane over a couple of days at RT. It is stable in the crystalline form.<br>References Phillips, A., et al.: Steroids, 55, 373 (1990); Rabiolo, A., et al.: Arch. Gynecol. Obstet., 294, 1317 (2016)<br></p>Fórmula:C21H29NO2Cor e Forma:Off-WhitePeso molecular:327.46Betamethasone 17-Propionate 21-Mesylate
CAS:<p>Impurity Clobetasol Propionate EP Impurity I<br>Stability Hygroscopic<br>Applications Betamethasone 17-Propionate 21-Mesylate (Clobetasol Propionate EP Impurity I) is the 21-mesylate analogue of Betamethasone 17-Acetate (B327015) with antiinflammatory activity.<br>References Mitsukuchi, M. et al.: Chem. Pharm. Bull., 37, 3286 (1989);<br></p>Fórmula:C26H35FO8SCor e Forma:NeatPeso molecular:526.61Dexamethasone Acetate Impurity E
CAS:<p>Applications Dexamethasone Acetate Impurity E is a pregn-4-ene derivative used in the preparation of antiallergic and antiinflammatory drugs.<br>References Nedelec, L., et al.: Ger. Offen. (1978)<br></p>Fórmula:C24H33FO6Cor e Forma:NeatPeso molecular:436.512-Hydroxy Atorvastatin Lactone
CAS:Produto Controlado<p>Impurity Atorvastatin 2-Hydroxy Lactone<br>Stability Hygroscopic<br>Applications A metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.<br></p>Fórmula:C33H33FN2O5Cor e Forma:Off White SolidPeso molecular:556.62Dutasteride-13C6
CAS:Produto Controlado<p>Applications Labelled Dutasteride (D735000). Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.<br>References Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),<br></p>Fórmula:C2113C6H30F6N2O2Cor e Forma:NeatPeso molecular:534.496-Hydroxymethyl Exemestane
CAS:Produto Controlado<p>Applications A potential metabolite of Exemestane (E957000).<br>References Buzzetti, F., et al.: Steroids, 58, 527 (1993),<br></p>Fórmula:C20H24O3Cor e Forma:NeatPeso molecular:312.40
![(3aR,4R,5R,6aS)-Hexahydro-4-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]-2-oxo-2H-cyclopenta[b]furan…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FH294040.webp&w=3840&q=75)
![(16α)-16-Methyl-17,20:20,21-bis[methylenebis(oxy)]-pregna-1,4-diene-3,11-dione](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FM297605.webp&w=3840&q=75)
![16-Methyl-17,20:20,21-bis[methylenebis(oxy)]-pregn-4-ene-3,11-dione](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FM293570.webp&w=3840&q=75)
![(3aR,4R,5R,6aS)-4-Formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FF700960.webp&w=3840&q=75)
![[1S-(1α,3aBeta,4β,7aAlpha)]-4-[2-(2,5-Dihydroxyphenyl)ethyl]octahydro-1-hydroxy-7a-methyl-5H-inden…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FD458310.webp&w=3840&q=75)
![(11β,16α)-9-Bromo-21-[(ethoxycarbonyl)oxy]-11-(formyloxy)-17-hydroxy-16-methylpregna-1,4-diene-3,2…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FB683236.webp&w=3840&q=75)
![(11β,16β)-11,21-bis(acetyloxy)-2'-methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione(Deflazaco…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FB400605.webp&w=3840&q=75)
