Terpenoides e Derivados

<p>Applications Labelled Campesterol (C155360). A phytosterol, which may inhibit the intestinal absorption of cholesterol.<br>References Fransen, H., et al.: J. Nut., 140, 1062 (2010), Kojoma, M., et al.: Plant Biotechnol., 27, 59 (2010), Orozco-Solano, M., et al.: J. Agric. Food Chem., 58, 7539 (2010),<br></p>

<p>Applications Campesterol is a phytosterol that may inhibit the intestinal absorption of cholesterol.<br>References Fransen, H., et al.: J. Nut., 140, 1062 (2010), Kojoma, M., et al.: Plant Biotechnol., 27, 59 (2010), Orozco-Solano, M., et al.: J. Agric. Food Chem., 58, 7539 (2010),<br></p>

<p>Applications An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.<br>References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),<br></p>

<p>Applications 3H-4,7a-Methanocyclohept[3,3a]indeno[5,4-b]oxete Benzenepropanoic Acid derivative is an analogue of Paclitaxel (P132500) and has weak antimitotic activity.<br>References Chen, S.H., et. al.: Tetrahedron Lett., 33, 7679 (1992)<br></p>

<p>Impurity Paclitaxel Side Chain Impurity 1<br>Applications (2R,3S)-N-Benzoyl-3-phenylisoserine is an intermediate in the preparation of potent anticancer drug Paclitaxel (P132500) used to study the location of the binding sites. (2R,3S)-N-Benzoyl-3-phenylisoserine shows cytotoxic, antiviral and immunomodulatory activity. Paclitaxel Side Chain Impurity 1.<br>References Paal, K. et al.: Bioorg. Med. Chem., 15, 1323 (2007); Krawczyk, E. et al.: J. Pharm. Pharmacol., 57, 791 (2005);<br></p>

<p>Applications A metabolite of all-trans Retinoic acid (R250200).<br>References Idres, N., et al.: Cancer Res., 61, 700 (2001), Taimi, M., et al.: J. Biol. Chem., 279, 77 (2004), Vermot, J., et al.: Science, 308, 563 (2005),<br></p>

<p>Impurity Paclitaxel - impurity G<br>Applications A semi-synthetic precursor of Paclitaxel. Paclitaxel - impurity G.<br></p>

<p>Applications The natural isomer of the abscission-accelerating plant hormone.<br>References Krochko, J.E., et al.: Plant Physiol., 118, 849 (1998), Jacobsen, J.V., et al.: Psysiol. Plant., 115, 428 (2002),<br></p>

<p>Applications Artemether- 13C, d3, is the labeled analogue of Artemether (A777400), which is a derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant.<br>References Hombhanje, F., et al.: Pharma., 3, 3581 (2010), Michael, O., et al.: Malaria J., 9, 335 (2010), Cesar, I., et al.: J. Pharm. Biomed. Anal., 54, 114 (2011),<br></p>

<p>Stability Light and Temperature Sensitive<br>Applications A metabolite of Retinoic acid.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hoyos, B., et al.: J. Exp. Med.,192, 835 ( 2000), Braungart, E., et al.: J. Invest. Dermatol.,116, 778 (2001), Fray, M., et al.: J. Med. Chem., 46, 3514 (2003), Ha, M., et al.: Exp. Dermatol., et al.: 13, 543 (2004),<br></p>

<p>Stability Hygroscopic<br>Applications 20(S)-Ginsenoside Rg2 is used as an aldose reductase inhibitor and my exert anti-inflammatory and immunomodulatory activity. It exists as a bioactive metabolite of the ginsenoside component of Panax ginseng.<br>References Cho, K. et al.: Biomol. Ther., 22, 55 (2014); Fatmawati, S. et al.: Bioorg. Med. Chem. Lett., 24, 4407 (2014);<br></p>

<p>Applications Artemisinin (A777500) is an effective antimalarial agent used to treat malaria. Artemisinic Aldehyde is converted into dihydroartemisinic aldehyde by Artemisinic aldehyde Δ11 (13) reductase (DBR2), which is involved in the biosynthetic pathway of artemisinin in Artemisia annua L.<br>References Yuan, Y., et al.: Biotechnol Appl Biochem 62, 17 (2015); Arjen, M. D., et al.: N Engl J Med 361, 455 (2009)<br></p>

<p>Applications Gibberellin A4 is a plant growth hormone that regulates growth and differentiation of plant cells for elongation, germination and enzyme induction.<br>References Zhang, R., et al.: Trees., 26, 1113 (2012); Sinska, I., et al.: Plant. Sci. Lett., 9, 163 (1977);<br></p>

<p>Impurity Paclitaxel - Impurity K<br>Applications Protected Paclitaxel. Paclitaxel - Impurity K.<br>References Kerns, E., et al.: J. Nat. Products, 57, 1391 (1994), Golik, J., et al.: Bioorg. Med. Chem. Lett., 6, 1837 (1996),<br></p>

<p>Applications 13-cis-Fenretinide, is an isomer of all-trans-Fenretinide (F250000), which is a synthetic analog of Vitamin A.<br>References Marth, C., et al.:J. Nat. Cancer Inst., 75, 871 (1985), Delia, D., et al.: Cancer Res., 53, 6036 (1993), Costa., A., et al.: Cancer Res., 54, Suppl., 2032s (1994), Decensi., A., et al.: Eur. J. Cancer Prev., 3, 377 (1994)<br></p>

<p>Applications Gamma Oryzanol is a mixture of 6 substances derived from rice bran oil, including sterols and ferulic acid, called Cycloartanyl Ferulate or Triterpene alcohol ferulate. It has been approved in Japan for several conditions, including menopausal symptoms, mild anxiety, stomach upset, and high cholesterol. In the US, it is widely used as a sports supplement, as well as for reducing cholesterol.Gamma Oryzanol is widely used as a food additive, pharmaceutical material. In cosmetic area, the application to creams and sunscreens exploiting its skin age resistor function and ultraviolet absorbing effect.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Somogyi, M., et al.: J. Biol. Chem., 195, 19 (1952), Wiseman, H., et al.: Biochemical. J., 313, 17 (1996), Banchuen, J., et al.: J. Agricul. Sci., 2009, 42, 191 (2009),<br></p>

<p>Applications γ-Eudesmol can be isolated from the essential oil of Tanacetum hololeucum. γ-Eudesmol exhibits antibacterial and antioxidant properties.<br>References Hamed, S., et al.: Rec Nat Prod 10, 818 (2016); Ud-Daula, A. F. M. S., et al.: Ind Crops Prod. 84, 189 (2016);<br></p>

<p>Impurity Paclitaxel - Impurity N<br>Applications A precursor to Paclitaxel, a neoplasm inhibitor to ovarian and breast cancers found in Taxus species. Paclitaxel - Impurity N.<br>References Katkovcinova, Z., et al.: J. Biosci., 63, 721 (2008), Tian, J., et al.: J. Pharm. Sci., 97, 3100 (2008), Miao, Z., et al.: App. Biochem. Microbiol., 45, 81 (2009),<br></p>

<p>Applications Movento is a synergistic insecticide. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Byrne, F., et al.: Crop. Prot., 25, 831 (2006), Kanrar, B., et al.: Bull Environ. Contam. Toxicol., 77, 631 (2006), Venkateswarlu, P., et al.: Food Chem., 105, 1760 (2007), Khay, S., et al.: Biomed. Chromatogr., 22, 581 (2008),<br></p>

<p>Applications ISOBORNYL ACRYLATE (cas# 5888-33-5) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications DL-Camphene, is a minor constituent of many essential oils such as turpentine, cypress oil, camphor oil, citronella oil (C525020), neroli, ginger oil, and valerian. It can also be used in fragrances and as a food additive for flavoring.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Perino-Issartier, S., et al.: J. Chromatography A, 1305 (2013); Zhang, L., et al.; Shizhen Guoyi Guoyao, 23, 3061 (2012);<br></p>

<p>Applications Paclitaxel-13C is the labeled analogue of Paclitaxel (P132500). Paclitaxel is an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.<br>References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),<br></p>

<p>Stability Light Sensitive<br>Applications Isotope labelled Permethrin (P288500), which is a synthetic pyrethroid insectide, more stable to light and at least as active as the natural pyrethrins (1) and with low mammalian toxicity (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Elliot, M. et al.: Nature. 1973 Nov 16;246(5429):169-70.2. Muturi, E. et al.: Sci Rep. 2017 Mar 16;7:44565.<br></p>

<p>Applications Levomenol is used in as an anti-inflammatory agent extracted from chamomile. Also functions as an anti-irritant, in rodents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Andersen, F. et al.: Contact Derm., 55, 148 (2006); Jakovlev, V. et al.: Planta Med., 35, 125 (1979);<br></p>

<p>Applications Campesteryl Ferulate is a component of γ-​oryzanol with antioxidant activities.<br>References Xu, Z., et al.: J. Agric. Food Chem., 49, 2077 (2001);<br></p>

<p>Stability Light Sensitive<br>Applications Carvone is useful for the treatment of various metabolic disorders and GI related disorders.<br>References Shabi, M. M., et al.: Res. J. Pharm. Biol. Chem. Sci., 8, 328 (2017)<br></p>

<p>Stability Light Sensitive<br>Applications trans-Permethrinic acid is a potent insecticide used in the agricultural industry to eliminate unwanted pests from crops. trans-Permethrinic acid is also metabolite of pyrethroid compounds, a group of pesticides that are relatively low toxicity (to organisms that are not intended to be targeted) and biodegradable.<br>References Kale, M., et al.: Toxicol. Lett., 105, 197 (1999); Leszczynski, J., et al.: J. Am. Chem. Soc., 115, 5891 (1993); Sodurlund, D. &amp; Bloomquist, J.: Ann. Rev. Entomol., 34, 77 (1989)<br></p>

<p>Applications Labelled Menthol. Used for oral gel patch or film containing herb extracts or Chinese medicine, fruit extract, spearmint, and menthol for smoking cessation.<br>References Ikaheimo, I., et al.: J. Antimicrob. Chemother., 46, 287 (2000), Gillet, Y., et al.: Lancet, 359, 753 (2002), Turos, E., et al.: Bioorg. Med. Chem. Lett., 2002, 12, 2229 (2002),<br></p>

<p>Applications ent-Kaurenoic Acid can be used in biological study. Kinetic profile of guaco syrup metabolites like coumarin, 7-hydroxycoumarin, o-coumaric acid, kaurenoic acid can be performed for identification of alternative route of coumarin metabolism in human plasma.<br>References Gasparetto, J. C., et al.: PLoS One, 10, 1-22 (2015)<br></p>

<p>Applications Deltamethrin intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kini, S., et al.: J. Enz. Inhibit. Med. Chem., 25, 730 (2010), Talele, T., et al.: Bioorg. Med. Chem., 18, 4630 (2010),<br></p>

<p>Applications 7-O-(Triethylsilyl)-10-deacetyl Baccatin III (cas# 115437-18-8_x000D_) is a compound useful in organic synthesis.<br></p>

<p>Applications Nordihydrocapsaicin is a capsaicinoid and analog and congener of capsaicin in chili peppers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Iwai, K., et al.: Agri. Biol. Chem., 43, 2493 (1979); Kozukue, N., et al.: J. Agr. Food Chem., 53, 9172 (2005)<br></p>

<p>Stability Light Sensitive<br>Applications A synthetic retinoid which is the major metabolite of Etretinate (E938000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sato, T., et al.: J. Med. Chem., 51, 7705 (2008), Liu, X., et al.: Cancer Chemother. Pharmacol., 63, 167 (2008),<br></p>

<p>Applications β-Selinene is a natural product found in essential oils from variety of plants. It is a functional antioxidant with antiradical and antimicrobial properties.<br>References Sacchetti, G., et al.: Food Chem., 91, 621 (2005); Bozin, B., et al.: J. Agric. Food Chem., 54, 1822 (2006);<br></p>

<p>Applications Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists.<br>References Korth, R., et al.: Eur. J. Pharmacol., 152, 101 (1988), Braquet, P., et al.: Med. Res. Rev., 11, 295 (1991), van Beek, T.A., et al.: Bioorg. Med. Chem., 13, 5001 (2005)<br></p>

<p>Stability Hygroscopic<br>Applications Ginsenoside Rg1 protects against arthitis through osteoclast differentiation inhibition. Anti-tumor agent, inhibits the NF-kB-dependant MMP-expression in PMA (phorbol myristate acetate)-induced tumor cell invasion.<br>References Gu, Y. et al.: Med. Infl., 305071/14. (2014); Li, L. et al. Onc. Rep., 32, 1779 (2014);<br></p>

<p>Applications One of the naturally occurring forms of Vitamin E. Isolated from soybean oil.<br>References Emerson, et al.: Science, 83, 421 (1936), Bieri, J.G., et al.: J. Nutr., 104, 850 (1974), Jiang, Q., et al.: Am. J. Clin. Nutr., 74, 714 (2001),<br></p>

<p>Applications Olivetol Dimethyl Ether is an intermediate in various syntheses of tetrahydrocannabinol.<br>References Bailey, K., et al.: Biochem. Pharmacol., 22, 2780 (1973), Poldy, J., et al.: Org. Biomol. Chem., 7, 4296 (2009),<br></p>

<p>Stability Light Sensitive<br>Applications A tetranortriterpinoid isolated from the seeds of the neem tree. Highly active insect feeding deterrent and growth regulator. Isolation from A. indica and identification as feeding inhibitor in locusts. Used experimentally as insect control agent. Azadirachtin is used in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Gill, J.S., et al.: Nature, 232, 402 (1971), Klocke, J.A., et al.: Entomol. Exp. Appl., 32, 299 (1982), Kubo, I., Agric. Biol. Chem., 46, 1951 (1982),<br></p>

<p>Applications Thymol is an antimicrobial compound which can increase the efficacy of antibiotics involving drug resistant bacteria. It inhibits growth and lactate production as well as reduces cellular glucose uptake within the bacteria.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Palaniappan, K. et al.: Int. J. Food Microbio., 140, 164 (2010); Evans, J. et al.: Curr. Microbiol., 41, 336 (2000);<br></p>

<p>Stability Hygroscopic<br>Applications O-Desmethyl Midostaurin is a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.<br>References Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Pedeboscq, S., et al.: PLoS. One., 7, 36811 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications 2-Debenzoyl-2-pentenoyldocetaxel is a related compound of Docetaxel (D494420), a chemotherapy drug that exhibits anti-mitotic properties and used for treating various metastatic cancers.<br>References Yokoyama, G., et al.: Int J Clin Oncol 10, 139 (2005); Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)<br></p>

<p>Applications Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists.<br>References Korth, R., et al.: Eur. J. Pharmacol., 152, 101 (1988), Braquet, P., et al.: Med. Res. Rev., 11, 295 (1991), van Beek, T.A., et al.: Bioorg. Med. Chem., 13, 5001 (2005)<br></p>

<p>Applications The major metabolites 1 and 3 (diastereomers) of Docetaxel.<br>References Van Asperen, J., et al.: J. Pharm. Sci., 86, 881 (1997), Bradshaw, D.M., et al.: J. Clin. Oncol., 16, 3674 (1998),<br></p>

<p>Stability Light Sensitive<br>Applications Permethrin is a synthetic pyrethroid insectide, more stable to light and at least as active as the natural pyrethrins (1) and with low mammalian toxicity (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Elliot, M. et al.: Nature. 1973 Nov 16;246(5429):169-70.2. Muturi, E. et al.: Sci Rep. 2017 Mar 16;7:44565.<br></p>

<p>Applications Abundant plant triterpene. Occurs in the skin of lupin seeds, in circle, in the latex of fig trees and of rubber plants. It was detected in cocoons of Bombyx mori.<br>References Owen, R., et al.: Food Chem. Toxicol., 38, 647 (2000), Salvador, M., et al.: Food Chem., 80, 359 (2003), Chiavaro, E., et al.: J. Agric. Food Chem., 55, 10779 (2007),<br></p>

<p>Applications (E)-Labd-13-ene-8,15-diol possesses antiviral and anticancer activities and has been the most effective growth inhibitor of murine leukemia cell lines P388.<br>References Kim, J., et. al.: J. App. Bio. Chem., 56, 49 (2013)<br></p>

<p>Applications Prallethrin is a synthetic pyrethroid; propynyl analog of allethrin. Prallethrin is used as an insecticide. Useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gersdorff, W.A., et al.: J. Econ. Entomol., 54, 1250 (1961), Matsuo, N., et al.: Pestic. Sci., 52, 21 (1998),<br></p>

<p>Stability Light Sensistive, Temperature Sensitive<br>Applications Geranylgeraniol, a precursor to Geranylgeranylpyrophosphate (G367600), is an intermediate in the mevalonate pathway. Geranylgeraniol has been shown to prevent bone re-adsorption, inhibition of osteoclast formation, and kinase activation in vitro.<br>References Aiuchi, T., et al.: J. Biochem., 124, 300 (1998), Fisher, J.E., et al.: Proc. Natl. Acad. Sci. U.S.A. 96, 133 (1999), Montero, M.T., et al.: J. Immunol., 173, 4936 (2004), Campia, I., et al.: Br. J. Pharmacol., 158, 1777 (2009),<br></p>

<p>Applications Sclareolide is found in Salvia yosgadensis and is a close analog of sclareol, an antifungal diterpene.<br>References Topcu, G., et. al.: J. Nat. Prod., 59, 113 (1996); Jasinski, M., et. al.: Plant Cell, 13, 1095 (2001)<br></p>

<p>Applications Oxazolidine Cabazitaxel is an impurity of Cabazitaxel (C046500) which is a novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer.<br>References Agarwal, N. et al.: Fut. Oncol., 7, 15 (2011); Mita, A. et al.: Clin. Cancer Res., 15, 723 (2009); Figg, W.D. et al.: Cancer Biol. Ther., 10, 1233 (2010);<br></p>

<p>Applications Bicyclo[2.2.1]hept-2-ene is a catalyst used in many reactions such as in the cascade cyclizations of iodoarene, bromobenzylamine, and electron-deficient alkene derivatives and arene C-H amination with aryl halides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Narbonne, V., et. al.: Org. Lett., 16, 628 (2014); Dong, Z., Dong, G.: J. Am. Chem. Soc., 135, 18350 (2013)<br></p>

<p>Stability Hygroscopic<br>Applications Camphor benzalkonium methosulfate is a sunscreen agent found in cosmetics.<br>References Gagliardi, L., et al.: J. Chromatogr., 408, 409 (1987); Dean, S. W., et al.: Mutagenesis, 7, 179 (1992);<br></p>

<p>Applications Geraniol is used in the synthesis of insect repellant. It is also used in the synthesis of Angelicoin A and Herecinone J, which inhibit collagen-induced platelet aggregation.<br>References Barnard, D. et al.: J. Med. Entomol., 41, 726 (2004); Mori K. et al.: Phytomedicine, 17, 1082 (2010);<br></p>

<p>Applications Campestanol can be used as analyte in biological and analytical studies for the determination of 22 natural brassinosteroids in a minute sample of plant tissue by UHPLC-ESI-MS/MS.<br>References Tarkowska, D., et al.: Anal. Bioanal. Chem., 408, 6799-6812 (2016)<br></p>

<p>Stability Light Sensitive<br>Applications D-α-Tocopherol Quinone is an vitamin E derivative that exhibits antioxidant properties. D-α-Tocopherol Quinone has been shown to partially restore the activity of NADH dehydrogenase and used to investigate the electron transport system in rat hepatocyte and human erythrocyte.<br>References Sun, I. L., et al.: Proc. Natl. Acad. Sci. USA 89, 11126 (1992); Hosomi, A., et al.: FEBS Lett. 409, 105 (1997)<br></p>

<p>Applications (+)-Fenchone is a terpenoid with broad spectrum activity against infective agents. It is a constituent of the essential oil component of fennel fruit. Fenchone is widely used as a flavouring agent in food industries, and also for perfumery in cosmetics industries.<br>References Mafud, A. C., et al.: Chem. Biol. Interact., 244, 129 (2016); Kan, Y., et al.: Ankara Universitesi Eczacilik Fakultesi Dergisi, 35, 95 (2006); Kpoviessi, S., et al.; J. Ethnopharmacol., 151, 652 (2014)<br></p>

<p>Applications Ginsenoside Rf is an anti-arthritic agent, attenuating collagen-induced arthritis in mice.<br>References Jung, S., et al.: Endale, Med. Inflamm., 748964/1 (2014); Wang, H., et al.: J. Pharm. Biomed. Anal., 98, 296 (2014);<br></p>

<p>Applications The major human metabolite of Docetaxel (D494420), an antineoplastic.<br>References Van Asperen, J., et al.: J. Pharm. Sci., 86, 881 (1997), Bradshaw, D.M., et al.: J. Clin. Oncol., 16, 3674 (1998),<br></p>

<p>Stability Hygroscopic<br>Applications Ginsenoside C-K is reported to exhibit anti-wrinkle effects. Also, it potentiates tumor necrosis factor (TNF)-related apotosis-inducing ligand (TRAIL)-induced apotosis in HCT116 colon cancer.<br>References Han, S., et al.: J. Cell. Biochem., (2017); Chen, L., et al.: Cell Death Diff., 7, 2334 (2016)<br></p>

<p>Stability Liight Sensitive, Temperature Sensitive<br>Applications Occurs preformed only in animals; metabolized from carotenoids, such β-carotene, in the intestinal mucosa. Dietary sources include liver, milk, butter, cheese, eggs and fish liver oils or as carotenois from fruits and vegetables. Stored primarily in the liver in esterified form; transported in the blood by retinol binding protein (RBP). Nutritional factor.<br>References Davis, M., et al.: J. Biol. Chem., 15, 167 (1913), Crouch, R.K., et al.: Photochem. Photobiol., 64, 613 (1996),<br></p>

<p>Impurity Docetaxel EP Impurity B<br>Stability Epimerize in solution<br>Applications 10-Oxo Docetaxel (Docetaxel EP Impurity B) is a novel taxoid having remarkable anti-tumor properties. Docetaxel (D494420) intermediate. This product is unstable in solution, epimerize.<br>References Appendino, G., et al.: Tetrahedron Lett., 37, 7836 (1996),<br></p>

<p>Stability Hygroscopic<br>Applications A major bioactive component of panax ginseng that promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway. It has been reported to display immunostimulatory and anticancer effects.<br>References Xue, J. et al.: Brain Res., 1106, 91 (2006); Kim, B. et al.: J. Ginseng Res., 33, 330 (2009); Li, B. et al.: Cancer Lett., 289, 62 (2010);<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications A metabolite of vitamin A (Retinol) (R252000).<br>References Allo, S., et al.: J. Biol. Chem., 266, 22003 (1991), Brancolini, C., et al.: J. Cell Biol., 139, 759 (1997), Bubb, M., et al.: J. Biol .Chem., 269, 14869 (1994),<br></p>

<p>Stability Hygroscopic<br>Applications β-Tocopherol (Racemic Mixture) is one of the naturally occurring forms of Vitamin E. Is biologically less active than α-Tocopherol. This is the racemic mixture of all stereoisomers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bianchi, G., et al.: Eur. J. Lipid Sci. Technology, 105, 229 (2003), Sakouhi, F., et al.: Food Chem., 108, 833 (2008),<br></p>

<p>Applications Ginsenoside Rh4 possesses inhibitory and antifungal activity.<br>References Xue, P., et al: RSC Adv., 7, 10939-10946 (2017)<br></p>

<p>Stability Hygroscopic<br>Applications Cantharidin is a well known natural compound produced by beetles of the Meloidae and Oedemeridae families. Insecticidal toxin. Apoptosis inducer in human H460 human lung cancer cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Khan, R. et al.: GMR. Gen. Mol. Res., 12, 4393 (2013); Hsia, T. et al.: Int. J. Onc., 45, 245 (2014);<br></p>

<p>Applications Artemisinic Alcohol is a compound that may be useful for semi-synthesis of Artemisinin (A777500), which is an effective antimalarial agent used to treat malaria.<br>References Yuan, Y., et al.: Biotechnol Appl Biochem 62, 17 (2015); Arjen, M. D., et al.: N Engl J Med 361, 455 (2009)<br></p>

<p>Applications Gibberellin A7 is an plant hormone that was isolated from culture filtrates of the fungus Gibberella fujikuroi. Gibberellin A7 was shown to promote the growth and elongation of cells.<br>References Cross, B.E., et al.: Tetrahedron., 8, 451 (1962); Meijon, M., et al.: J. Plant. Growth. Regulat., 30, 74 (2011); Ward, D.A., et al.: Phytochem., 71, 2010 (2010);<br></p>

<p>Applications Olivetol-d9 is a precursor in various syntheses of labelled tetrahydrocannabinols.<br>References Kumano, T., et al.: Bioorg. Med. Chem., 16, 8117 (2008), Appendino, G., et al.: J. Nat. Prod., 71, 1427 (2008), Sampietro, D., et al.: Food Chem., 115, 1170 (2009),<br></p>

<p>Applications A metabolite of Artemether (A777400) and derivative of the antimalarial drug Artemisinin (A777500). Studies suggest that it may display neurotoxicity in animals due to its interaction with iron.<br>References Smith, S.L. et al.: Neurotoxicology, 19, 557 (1998); Blum, W. et al.: J. Chrom. B Biomed. Sci. Appl., 710, 101 (1998);<br></p>

<p>Stability Light Sensitive<br>Applications α-Tocopherol is the most bioactive of the naturally occurring forms of Vitamin E. Richest sources are green vegetables, grains, and oils, particularly palm, safflower and sunflower oils.<br>References Bianchi, G., et al.: Eur. J. Lipid Sci. Technology, 105, 229 (2003), Sakouhi, F., et al.: Food Chem., 108, 833 (2008),<br></p>

<p>Applications Artemether (A777400) impurity. Artemisinin impurity<br>References Pandey, A., et al.: J. Biol. Chem., 274, 19383 (1999), Kremsner, P., et al.: Lancet, 364, 285 (2004),<br></p>

<p>Applications Amorphadiene is a sesquiterpene synthesized via the cyclization of farnesyl pyrophosphate and a precursor in the biosynthesis of Artemisinin (A777500), which is an effective antimalarial agent used to treat malaria. Genetically modified Saccharomyces cerevisiae can be utilized as an alternative semisynthetic strategy to produce artemisinin from amorphadiene.<br>References Wallaart, T. E., et al.: Planta 212, 460 (2001); Westfall, P. J. et al.: Proc. Natl. Acad. Sci. USA 109, E111 (2012); Shiba, Y., et al.: Metab. Eng 9, 160 (2007).<br></p>