1-Ethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS: 6490-42-2
Ref. 3D-GAA49042
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Informação sobre produto
1-Ethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (ETP) is a potent inhibitor of pyrimidine biosynthesis. It has been shown to inhibit the growth of cancer cells in vitro and in vivo. ETP binds to the enzyme dihydroorotate dehydrogenase and prevents the formation of orotic acid from l-tartaric acid. This inhibition leads to an accumulation of orotic acid and l-tartaric acid in the cell which inhibits cellular respiration. ETP also inhibits other enzymes involved in DNA replication, such as ribonucleotide reductase and thymidylate synthase. This inhibition leads to decreased synthesis of DNA and RNA molecules that are necessary for cell division. ETP has also been shown to be effective against hepatitis B virus by inhibiting viral DNA synthesis and causing viral DNA degradation.
Propriedades químicas
Consulta técnica sobre: 3D-GAA49042 1-Ethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
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