3'-epi-5-chloro-2'-deoxyuridine

CAS: 188559-94-6

Ref. 3D-NE16712

Informação sobre produto

• Nome: 3'-epi-5-chloro-2'-deoxyuridine
• Sinónimos: 5-Chloro-1-(2-deoxy-b-D-threo-pentofuranosyl)-2,4(1H,3H)-pyrimidinedione
• Marca: Biosynth
• Descrição: 3'-epi-5-chloro-2'-deoxyuridine is a nucleotide analog that has been shown to inhibit the growth of cells in tissue culture. It is not active against bacteria, but can be used as an antineoplastic agent for the treatment of cancer. 3'-epi-5-chloro-2'-deoxyuridine is metabolized by a number of enzymes, including mononucleotide reductase, thymidylate synthase, and cytosine deaminase. The reaction mechanism for this drug has been studied using nuclear dna polymerases and proteases. The metabolism of 3'-epi-5-chloro-2'-deoxyuridine results in its incorporation into DNA by means of an enzymatic reaction with DNA polymerase. The incorporation of the analog into DNA leads to cell death due to lysis or inhibition of protein synthesis.

Propriedades químicas

• Peso molecular: 262.65 g/mol
• Fórmula: C₉H₁₁ClN₂O₅
• Pureza: Min. 95%