S-(2-Hydroxy-5-nitrobenzoyl)-6-thioguanosine
CAS: 41094-07-9
Ref. 3D-NH08019
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Informação sobre produto
- 2-Amino-6-[(2-hydroxy-5-nitrobenzyl)thio]-9-(b-D-ribofuranosyl)purineS-(2-Hydroxy-5-nitrobenzoyl)-6-thio-D-guanosine
- 2-Hydroxy-5-nitrobenzylthioguanosine
- 2-Hydroxy-5-nitrobenzyl-6-thioguanosine
- Hnbtg
- Hydroxynitrobenzoylthioguanosine
- Phenol, 2-(((2-amino-9-beta-D-ribofuranosyl-9H-purin-6-yl)thio)methyl)-4-nitro-
- 6-[(2-hydroxy-5-nitrobenzyl)sulfanyl]-9-(beta-D-ribofuranosyl)-9H-purin-2-amine
S-(2-Hydroxy-5-nitrobenzoyl)-6-thioguanosine is a benzodiazepine derivative that inhibits the uptake of uridine into cells. It binds to adenosine receptors and inhibits neurotransmission by preventing the release of the inhibitory neurotransmitter GABA. S-(2-Hydroxy-5-nitrobenzoyl)-6-thioguanosine also has an inhibitory effect on mitochondrial function, which may be due to its ability to bind with and inactivate mitochondrial enzyme succinate dehydrogenase. This drug is potent in inhibiting uptake assays, but has low potency and poor bioavailability as a result of its covalent linkages.
Propriedades químicas
Consulta técnica sobre: 3D-NH08019 S-(2-Hydroxy-5-nitrobenzoyl)-6-thioguanosine
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