Atorvastatin Epoxy Pyrrolooxazin Tricyclo Methane

Ref. TR-A791803

Informação sobre produto

• Nome: Atorvastatin Epoxy Pyrrolooxazin Tricyclo Methane
• Sinónimos: Methyl 2-(9-(4-Fluorophenyl)-1b-isopropyl-9a-phenyl-1a-(phenylcarbamoyl)octahydro-1aH-5,9-epoxyoxireno[2',3':3,4]pyrrolo[2,1-b][1,3]oxazocin-3-yl)acetate

Descrição

Applications Atorvastatin Epoxy Pyrrolooxazin Tricyclo Methane is an intermediate in the synthesis of Atorvastatin Epoxy Pyrrolooxazin Tricyclic Potassium Salt (A791895), a photodegadation product of Atorvastatin (a cyclic impurity of Atorvastatin (A791750)), a selective, competitive HMG-CoA reductase . Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.
References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000),

• Marca: TRC

Propriedades químicas

• Peso molecular: 586.65
• Fórmula: C₃₄H₃₅FN₂O₆
• Cor/forma: Off-White
• InChI: InChI=1S/C34H35FN2O6/c1-22(2)33-32(30(39)36-26-12-8-5-9-13-26)31(43-32,23-10-6-4-7-11-23)34(24-14-16-25(35)17-15-24)37(33)19-18-27(41-34)20-28(42-33)21-29(38)40-3/h4-17,22,27-28H,18-21H2,1-3H3,(H,36,39)
• Chave InChI: InChIKey=OKXAXTMLLBWBAO-UHFFFAOYSA-N
• SMILES: COC(=O)CC1CC2CCN3C(c4ccc(F)cc4)(O2)C2(c4ccccc4)OC2(C(=O)Nc2ccccc2)C3(C(C)C)O1