(3S)-1-Azabicyclo[2.2.2]octan-3-ol

CAS: 34583-34-1

Ref. TR-A795295

Informação sobre produto

• Nome: (3S)-1-Azabicyclo[2.2.2]octan-3-ol
• Sinónimos: 1-Azabicyclo[2.2.2]octan-3-ol, (S)-, (+)-Quinuclidin-3-ol, (3S)-(+)-Quinuclidin-3-ol, (3S)-Quinuclidin-3-ol, (S)-(+)-1-Azabicyclo[2.2.2]octan-3-ol, (S)-(+)-3-Quinuclidinol, (S)-(+)-Azabicyclo[2.2.2]octane-3-ol, (S)-1-Azabicyclo[2.2.2]octan-3-ol, (S)-3-Hydroxyquinuclidine, (S)-3-Quinuclidinol, (S)-(+)-3-Hydroxyquinuclidine, (S)-3-Quinuclidinol. Hydrochloride, (3S)-1-azabicyclo[2.2.2]octan-3-ol

Descrição

Applications (3S)-1-Azabicyclo[2.2.2]octan-3-ol is an intermediate in the synthesis of Solifenacin Hydrochloride (S676700), a muscarinic M3 receptor antagoinst. Used in treatment of urinary incontinence. Also used in the synthesis of new anticholinergenic drugs such as penehyclidine hydrochloride.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ikeda K., et al.: Arch. Pharmacol., 366, 97, (2002), Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004), Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004), Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005), Habb, F., et al.: Eur. Urol. 47, 376 (2005), Payne, C.K., et al.: Drugs, 66, 175 (2006); Naito, R. et al.: J. Med. Chem., 48, 6597 (2005); Liu, Y. et al.: J. Chem. Res., 5, 335 (2006);

• Marca: TRC

Propriedades químicas

• Peso molecular: 127.18
• Fórmula: C₇H₁₃NO
• Cor/forma: Neat
• InChI: InChI=1S/C7H13NO/c9-7-5-8-3-1-6(7)2-4-8/h6-7,9H,1-5H2/t7-/m1/s1
• Chave InChI: InChIKey=IVLICPVPXWEGCA-ZETCQYMHSA-N
• SMILES: O[C@H]1C[N@]2CC[C@@H]1CC2