O-t-Butyldiphenylsilylhydroxylamine

CAS: 103587-51-5

Ref. TR-B820030

Informação sobre produto

• Nome: O-t-Butyldiphenylsilylhydroxylamine
• Sinónimos: O-[(1,1-Dimethylethyl)diphenylsilyl]hydroxylamine, (t-Butyldiphenylsilyloxy)amine, O-[(1,1-Dimethylethyl)diphenylsilyl]-hydroxylamine, O-DPTBS hydroxylamine, Hydroxylamine, O-[(1,1-dimethylethyl)diphenylsilyl]-

Descrição

Applications O-t-Butyldiphenylsilylhydroxylamine is an intermediate in synthesizing N-Hydroxy Vortioxetine O-β-D-Glucuronide Sodium Salt (H996005), which is a metabolite of Vortioxetine (V766000, HBr); a multimodal serotonergic agent which inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT.
References Bang-Andersen, B., et al.: J. Med. Chem., 54, 3206 (2011); Mørk, A., et al.: J. Pharmacol. Exp. Ther., 340, 666 (2012); Mørk, A., et al.: Pharmacol. Biochem. Behav. 105C, 41 (2013); Uldam, H.K., et al.: Drug Metab. Dispos., 39, 2264 (2011);

• Marca: TRC

Propriedades químicas

• Peso molecular: 271.43
• Fórmula: C₁₆H₂₁NOSi
• Cor/forma: Neat
• InChI: InChI=1S/C16H21NOSi/c1-16(2,3)19(18-17,14-10-6-4-7-11-14)15-12-8-5-9-13-15/h4-13H,17H2,1-3H3
• Chave InChI: InChIKey=PWTWOGMXABHJOA-UHFFFAOYSA-N
• SMILES: CC(C)(C)[Si](ON)(c1ccccc1)c1ccccc1