CAS 1007786-48-2

Formel: C19H18N4OS2

InChl: InChI=1S/C19H18N4OS2/c1-9-11(3)25-19-15(9)17(24)22-16(23-19)12(4)26-18-10(2)20-13-7-5-6-8-14(13)21-18/h5-8,12H,1-4H3,(H,22,23,24)

InChI Key: ZYCFQLYFRCQEMK-UHFFFAOYSA-N

SMILES: CC1=C(SC2=C1C(=O)NC(=N2)C(C)SC3=NC4=CC=CC=C4N=C3C)C

JNK-IN-23

CAS: 1007786-48-2

JNK-IN-23 (Compound K12) is an inhibitor of JNK. It effectively inhibits the proliferation of MDA-MB-231 cells with a GIC50 of 30 nM. In vivo, JNK-IN-23 blocks metastatic growth of triple-negative breast cancer (TNBC). Additionally, it suppresses the growth of lung metastases by dual targeting of glutaminase-1 (GLS) and the pyruvate dehydrogenase complex (PDHC).

Formel: C₁₉H₁₈N₄OS₂

Farbe und Form: Solid

Molekulargewicht: 382.50

Ref: TM-T210950