CAS 1011641-78-3

D34-919

Formel: C22H27N5OS

InChl: InChI=1S/C22H27N5OS/c1-22(2,3)16-7-5-14(6-8-16)18-17(13-23)20(26-21(25-18)29-4)27-11-9-15(10-12-27)19(24)28/h5-8,15H,9-12H2,1-4H3,(H2,24,28)

InChI Key: IOTHJSIAPSZEHT-UHFFFAOYSA-N

SMILES: CC(C)(C)C1=CC=C(C=C1)C2=C(C(=NC(=N2)SC)N3CCC(CC3)C(=O)N)C#N

Synonyme:

• D34-919

D34-919

CAS: 1011641-78-3

D34-919 is a potent inhibitor of the ALDH1A3-PKM2 interaction, effectively inhibiting the ALDH1A3-mediated tetramerization enhancement of PKM2. Treatment mediated by D34-919 both in vitro and in vivo enhances and restores apoptosis and sensitivity in glioblastoma (GBM) cells induced by radiochemotherapy.

Formel: C₂₂H₂₇N₅OS

Farbe und Form: Solid

Molekulargewicht: 409.55

Ref: TM-T201370