CAS 1211877-36-9

Formel: C26H41N3O5

InChl: InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22+,23-/m0/s1

InChI Key: TZYWCYJVHRLUCT-ZRBLBEILSA-N

SMILES: CC(C)C[C@@H](C=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1

(R)-MG-132

CAS: 1211877-36-9

(R)-MG-132

Formel: C₂₆H₄₁N₃O₅

Reinheit: ≥98%

Molekulargewicht: 475.62

Ref: 54-BUP12924

N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-D-leucinamide

CAS: 1211877-36-9

Formel: C₂₆H₄₁N₃O₅

Reinheit: 95%

Farbe und Form: Solid

Molekulargewicht: 475.6208

Ref: IN-DA009BMJ

(R)-MG-132

CAS: 1211877-36-9

Benzyl ((S)-1-(((R)-1-amino-4-methyl-1-oxopentan-2-yl)((S)-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate

Formel: C₂₆H₄₁N₃O₅

Reinheit: 98% (NMR）

Molekulargewicht: 475.62

Ref: IN-DG758089

(R)-MG-132

CAS: 1211877-36-9

(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.

Formel: C₂₇H₄₃N₃O₅

Reinheit: 99.90%

Farbe und Form: Solid

Molekulargewicht: 489.6474

Ref: TM-T12628

(R)-MG-132

Kontrolliertes Produkt

CAS: 1211877-36-9

Formel: C₂₆H₄₁N₃O₅

Farbe und Form: Neat

Molekulargewicht: 475.621

Ref: TR-M340975

(R)-MG 132

CAS: 1211877-36-9

Ischemia reperfusion injury is a major cause of irreversible brain damage. The enzyme GTPase-activating protein (GAP) has been shown to be involved in the regulation of cell death and may represent a potential therapeutic target for ischemia reperfusion injury. MG132 is an inhibitor of GAP and can protect against brain damage in wild-type mice subjected to cerebral ischemia reperfusion injury. MG132 blocks protein synthesis, leading to apoptotic cell death in cancer cells, while it induces apoptotic cell death in cancer cells. MG132 also inhibits proteasome activity and leads to acute ischemic brain damage in wild-type mice.

Formel: C₂₆H₄₁N₃O₅

Reinheit: Min. 95%

Molekulargewicht: 475.63 g/mol

Ref: 3D-LYB87736