CAS 1263-89-4

Paromomycinsulfat

Beschreibung:

Paromomycinsulfat ist ein Aminoglykosid-Antibiotikum, das hauptsächlich zur Behandlung von Infektionen eingesetzt wird, die durch bestimmte Arten von Bakterien verursacht werden, insbesondere in Fällen von intestinaler Amöbiasis und Leishmaniose. Es wird aus dem Bakterium Streptomyces griseus gewonnen und wirkt, indem es die Proteinsynthese in empfindlichen Mikroorganismen hemmt. Die Verbindung zeichnet sich durch ihre Fähigkeit aus, an die 30S-ribosomale Untereinheit zu binden, was zu einer fehlerhaften Ablesung der mRNA führt und letztendlich das Bakterienwachstum stört. Paromomycin wird typischerweise oral oder parenteral verabreicht, abhängig von der zu behandelnden Infektion. Es ist bekannt für seine relativ geringe Toxizität im Vergleich zu anderen Aminoglykosiden, obwohl es dennoch Nebenwirkungen wie gastrointestinale Störungen und Nephrotoxizität in einigen Fällen verursachen kann. Die Sulfatform verbessert seine Löslichkeit in Wasser, was es für verschiedene Formulierungen geeignet macht. Paromomycin wird auch auf sein potenzielles Einsatzgebiet bei der Behandlung von multiresistenten Infektionen untersucht, was seine Bedeutung im Bereich der antimikrobiellen Therapie unterstreicht.

Formel: C₂₃H₄₇N₅O₁₈S

InChl: InChI=1/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23?;/m1./s1

InChI Key: InChIKey=LJRDOKAZOAKLDU-UDXJMMFXSA-N

SMILES: S(=O)(=O)(O)O.O([C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H](CO)O2)[C@@H](O)[C@H](N)C[C@@H]1N)[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4N

Synonyme:

• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside sulfate (1:1)
• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-α-D-glucopyranoside sulfate (salt)
• (2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside sulfate (1:1)
• 1600 Antibiotic
• 4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxyhexopyranosyl)-D-lyxofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxyhexopyranoside sulfate (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:?)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-amino-2-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-β-<smallcap>D</span>-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (salt)
• Aminosidin sulfate
• Aminosidin sulphate
• Aminosidine Sulphate
• Aminosidine sulfate
• Aminoxidin
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (salt)
• D-Streptamine, O-2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (1:?)
• D-Streptamine, O-2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (salt)
• Farmiglucin
• Farminosidin
• Fi 5853
• Gabbroral
• Humagel
• Humatin
• Humycin sulfate
• O-2-Amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-D-streptamine sulfate (salt)
• Paramicina
• Pargonyl
• Paricina
• Paromomycin Sulphate
• Paromomycin Sulphates
• Paromomycin sulfate salt
• Paromomycinsulfate
• Sinosid
• Sulfates De Paromomycine
• Sulfatos De Paromomicina
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:?)
• Paromomycin sulfate
• D-Streptamine, O-2-amino-2-deoxy-a-D-glucopyranosyl-(14)-O-[O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(13)-b-D-ribofuranosyl-(15)]-2-deoxy-, sulfate (salt) (9CI)
• fi5853
• PayoMoMycin Sulfate
• Paromomycin sulphate solution,1000ppm solution
• Barone sulfate kanamycin Solution, 100ppm
• humycinsulfate
• Humatin (tn)
• Paromomycin sulfate (jan/usp)
• O - 2, 6 - Diamino - 2, 6 - dideoxy - b - L - idopyranosyl - (1,3) - O - b - D - ribofuranosyl - (1,5) - O - [2 - amino - 2 - deoxy - a - D - glucopyranosyl - (1,4) ] - 2 - deoxy - streptamine sulfate
• sulf
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(13)-O-b-D-ribofuranosyl-(15)-O-[2-amino-2-deoxy-a-D-glucopyranosyl-(14)]-2-deoxy-, sulfate (salt) (8CI)
• Paromomycin sulphate solution,100ppm
• aminosidinesulfate
• PAROMOMYCIN SULFATE CELL CULTURE REAGENT 97+%
• Paromomycin Sulfate (125 mg)
• paromomycin sulfate cell culture tested
• Paromomycin Sufate
• paromomycin sulfate plant cell*culture tested
• streptamine,o-2,6-diamino-2,6-dideoxy-beta-l-idopyranosyl-(1-3)-o-beta-d-ribof
• NEOMYCIN E
• aminosidinesulphate
• Paramomycinsulfate
• O-2,6-DiaMino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-aMino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-StreptaMine Sulfate
• aminosidinsulfate
• O-2-AMino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diaMino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-D-streptaMine Sulfate
• D00868
• PAROMOMYCIN SULFATE USP 97+%
• Paromomycin sulfate ,98%
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:1)

Paromomycin Sulfate

CAS: 1263-89-4, 7542-37-2, 84420-34-8

Formel: C₂₃H₄₅N₅O₁₄·xH₂SO₄

Reinheit: >92.0%(HPLC)

Farbe und Form: White to Almost white powder to crystal

Ref: 3B-P2092

Paromomycin sulfate

CAS: 1263-89-4

Inhibits initiation and elongation during protein synthesis

Formel: C₂₃H₄₇N₅O₁₈S

Farbe und Form: White to pale cream to pale yellow, Powder

Molekulargewicht: 713.71

Ref: 02-J61274

PAROMOMYCIN SULFATE RS

CAS: 1263-89-4

PAROMOMYCIN SULFATE RS

Formel: C₂₃H₄₅N₅O₁₄

Molekulargewicht: 615.6285

Ref: 41-ICRS0378

Paromomycin Sulfate

CAS: 1263-89-4

Aminoglycoside antibiotics

Formel: C₂₃H₄₅N₅O₁₄·xH₂SO₄

Farbe und Form: White Off-White Light Yellow Powder

Molekulargewicht: 615.2963

Ref: 45-1500003

Paromomycin sulphate

CAS: 1263-89-4

Paromomycin sulphate

Formel: C₂₃H₄₅N₅O₁₄·H₂SO₄

Reinheit: Ph - 6 loss on drying: 3.1% (Typical Value in Batch COA)

Farbe und Form: Solid

Molekulargewicht: 713.70698

Ref: 54-BIP0141

Paromomycin Sulfate

CAS: 1263-89-4

Paromomycin Sulfate, an aminoglycoside antibiotic, binds to 30S ribosomes, disrupting protein synthesis and killing bacteria.

Formel: C₂₃H₄₇N₅O₁₈S

Reinheit: 99.73% - 99.86%

Farbe und Form: Solid

Molekulargewicht: 713.71

Ref: TM-T1104

Paromomycin sulfate

CAS: 1263-89-4

Formel: C₂₃H₄₇N₅O₁₈S

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 713.7070

Ref: IN-DA0072SF

Paromomycin Sulfate

CAS: 1263-89-4

Paromomycin Sulfate

Formel: C₂₃H₄₇N₅O₁₈S

Reinheit: ≥98%

Molekulargewicht: 713.71

Ref: 54-BUP18626

Paromomycin sulfate salt

CAS: 1263-89-4

Formel: C₂₃H₄₅N₅O₁₄·H₂SO₄

Farbe und Form: White to off-white powder

Molekulargewicht: 713.71

Ref: 7W-GA4947

Paromomycin sulfate

Kontrolliertes Produkt

CAS: 1263-89-4

Formel: C₂₃H₄₅N₅O₁₄·H₂O₄S

Farbe und Form: Neat

Molekulargewicht: 713.71

Ref: 04-C15893500

Paromomycin Sulfate

CAS: 1263-89-4

Stability Hygroscopic
Applications an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed additive in turkey poults experimentally infected with Histomonas meleagridis.
References Rehg, J.E. et al.: J. Infect. Dis., 170, 934 (1994); Fong, D. et al.: Am. J. Trop. Med. Hyg., 51, 758 (1994); Hafez, H.M. et al.: Arch. Anim. Nut., 64, 77 (2010);

Formel: C₂₃H₄₅N₅O₁₄·H₂O₄S

Farbe und Form: Neat

Molekulargewicht: 713.71

Ref: TR-P205650

Paromomycin sulfate

CAS: 1263-89-4

Paromomycin sulfate is an aminoglycoside antibiotic with action on bacterial protein synthesis inhibition and is used for treating intestinal infections and leishmaniasis.

Formel: C₂₃H₄₅N₅O₁₄·xH₂SO₄

Reinheit: ≥675Μg/Mg(On Dried Basis)

Farbe und Form: Yellow Powder

Molekulargewicht: 615.63 g/mol

Ref: 3D-AP31110

Paromomycin sulfate, Antibiotic for Culture Media Use Only

CAS: 1263-89-4

Paromomycin sulfate is an antibiotic used for culture media to control bacterial contamination of mediums and other laboratory substances. Most Gram-negative bacteria strains are sensitive to paromomycin sulfate, showing a low sensitivity (≀10%) in Enterobacteriaceae, Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae and Serratia marcescens. Paromomycin sulfate is also used in the treatment of colorectal cancer by blocking DNA synthesis through inhibition of protein synthesis in susceptible cells. This can result in reduced damage in colon tumor cells within the body, although it may have neurotoxic effects on brain tissue. Furthermore, it has anti-inflammatory properties when given orally or intravenously at therapeutic doses. Acridine orange can be used to identify sulfuric acid resistant gram.

Formel: C₂₃H₄₇N₅O₁₈S

Reinheit: Min. 95.0 Area-%

Molekulargewicht: 713.71 g/mol

Ref: 3D-Q-201537

Paromomycin Sulfate (PRM)

CAS: 1263-89-4

Formel: C₂₃H₄₅N₅O₁₄·H₂SO₄

Farbe und Form: White to off-white, Powder

Molekulargewicht: 713.17

Ref: SR-27436

Paromomycin sulfate

CAS: 1263-89-4

Reinheit: 95+%

Molekulargewicht: 713.710022

Ref: 10-F806731

Neomycin sulfate EP Impurity E

CAS: 1263-89-4

Formel: C₂₃H₄₅N₅O₁₄H₂SO₄

Molekulargewicht: 615.63 : 98.07

Ref: ST-EA-CP-N53005