CAS: 1269440-17-6 - LGX818

Formel: C₂₂H₂₇ClFN₇O₄S

InChl: InChI=1S/C22H27ClFN7O4S/c1-12(2)31-11-16(17-6-7-25-21(28-17)26-10-13(3)27-22(32)35-4)20(29-31)15-8-14(23)9-18(19(15)24)30-36(5,33)34/h6-9,11-13,30H,10H2,1-5H3,(H,27,32)(H,25,26,28)/t13-/m0/s1

InChI Key: InChIKey=CMJCXYNUCSMDBY-ZDUSSCGKSA-N

SMILES: O=C(OC)NC(C)CNC=1N=CC=C(N1)C2=CN(N=C2C=3C=C(Cl)C=C(NS(=O)(=O)C)C3F)C(C)C

Synonyme:

• (S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate
• Braftovi
• Carbamic acid, N-[(1S)-2-[[4-[3-[5-chloro-2-fluoro-3-[(methylsulfonyl)amino]phenyl]-1-(1-methylethyl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]-1-methylethyl]-, methyl ester
• Encorafenib
• Lgx 818
• Nvp-Lgx 818Nxa

Carbamic acid, N-[(1S)-2-[[4-[3-[5-chloro-2-fluoro-3-[(methylsulfonyl)amino]phenyl]-1-(1-methylethyl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]-1-methylethyl]-, methyl ester

CAS: 1269440-17-6

• Formel: C₂₂H₂₇ClFN₇O₄S
• Reinheit: 98%
• Farbe und Form: Solid
• Molekulargewicht: 540.0107

Encorafenib

CAS: 1269440-17-6

Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.

• Formel: C₂₂H₂₇ClFN₇O₄S
• Reinheit: 99.74%
• Farbe und Form: Solid
• Molekulargewicht: 540.01

Encorafenib

CAS: 1269440-17-6

• Formel: C₂₂H₂₇ClFN₇O₄S
• Molekulargewicht: 540.01

LGX 818

CAS: 1269440-17-6

Applications LGX 818 is potent and selective BRAFV600E kinase inhibitor and can be used for …

• Formel: C₂₂H₂₇ClFN₇O₄S
• Farbe und Form: White to Off-White Solid
• Molekulargewicht: 540.01

LGX 818

CAS: 1269440-17-6

Inhibitor of B-Raf mutant (V600E); anti-neoplastic

• Formel: C₂₂H₂₇ClFN₇O₄S
• Reinheit: Min. 95%
• Farbe und Form: White/Off-White Solid
• Molekulargewicht: 540.01 g/mol