CAS 1332391-11-3

Formel: C20H13F4N5O2S

InChl: InChI=1S/C20H13F4N5O2S/c21-14-7-10(2-3-12(14)16(26)30)29-18(32)28(17(31)19(29)4-1-5-19)11-6-13(20(22,23)24)15(8-25)27-9-11/h2-3,6-7,9H,1,4-5H2,(H2,26,30)

InChI Key: BAANHOAPFBHUDX-UHFFFAOYSA-N

SMILES: C1CC2(C1)C(=O)N(C(=S)N2C3=CC(=C(C=C3)C(=O)N)F)C4=CC(=C(N=C4)C#N)C(F)(F)F

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.

Formel: C₂₀H₁₃F₄N₅O₂S

Reinheit: 98.6%

Farbe und Form: Solid

Molekulargewicht: 463.408

Ref: TM-T12146

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

N-Desmethyl-Apalutamide

Formel: C₂₀H₁₃F₄N₅O₂S

Reinheit: ≥95%

Molekulargewicht: 463.41

Ref: 54-BUP08683

N-Desmethyl Apalutamide

CAS: 1332391-11-3

Formel: C₂₀H₁₃F₄N₅O₂S

Farbe und Form: White To Off-White Solid

Molekulargewicht: 463.41

Ref: 4Z-A-284003

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

Formel: C₂₀H₁₃F₄N₅O₂S

Reinheit: 98%

Molekulargewicht: 463.4081

Ref: IN-DA01NV7R

N-Desmethyl Apalutamide

Kontrolliertes Produkt

CAS: 1332391-11-3

Applications N-Desmethyl Apalutamide has been exploresd asthiohydantion androgen receptor antagonist for treament of cancer
References Bignan, G.C. PCT Int. Appl. (2018), WO 2018037342 A1 20180301.

Formel: C₂₀H₁₃F₄N₅O₂S

Farbe und Form: Neat

Molekulargewicht: 463.41

Ref: TR-D291395

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzamide

Formel: C₂₀H₁₃F₄N₅O₂S

Reinheit: 98%

Molekulargewicht: 463.41

Ref: IN-DG01289413

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

Formel: C₂₀H₁₃F₄N₅O₂S

Molekulargewicht: 463.4

Ref: BE-RMCA245002

N-Desmethyl-Apalutamide

CAS: 1332391-11-3

Formel: C₂₀H₁₃F₄N₅O₂S

Molekulargewicht: 463.41

Ref: ST-EA-CP-A92016

N-Desmethyl Apalutamide-d4

Kontrolliertes Produkt

CAS: 1332391-11-3

Formel: C₂₀D₄H₉F₄N₅O₂S

Farbe und Form: Neat

Molekulargewicht: 467.433

Ref: TR-D291398

N-Desmethyl Apalutamide D-13C215N

Kontrolliertes Produkt

CAS: 1332391-11-3

Formel: C₂C₁₈H₁₃F₄₁₅NN₄O₂S

Farbe und Form: Neat

Molekulargewicht: 466.387

Ref: TR-D291397

N-Desmethyl-apalutamide

CAS: 1332391-11-3

Apalutamide is a nonsteroidal antiandrogen that binds to the androgen receptor in prostate cancer cells. It has been shown to inhibit the proliferation of human prostate cancer cell lines and tumor xenografts in nude mice. Apalutamide is a potent inhibitor of protein interactions with the androgen receptor, which may be due to its ability to compete with testosterone for binding sites. It also has an activating effect on the androgen receptor, leading to increased transcription of genes regulated by this receptor.

Formel: C₂₀H₁₃F₄N₅O₂S

Reinheit: Min. 95%

Molekulargewicht: 463.4 g/mol

Ref: 3D-HDC39111