CAS 1373822-39-9

Formel: C20H19ClN5O5P

InChl: InChI=1S/C20H19ClN5O5P/c1-22-20-24-17-16(19(27)25-20)26(10-11-31-14-6-4-13(21)5-7-14)18(23-17)12-2-8-15(9-3-12)32(28,29)30/h2-9H,10-11H2,1H3,(H2,28,29,30)(H2,22,24,25,27)

InChI Key: MCYZBWKMUOPJOU-UHFFFAOYSA-N

SMILES: CNC1=NC2=C(C(=O)N1)N(C(=N2)C3=CC=C(C=C3)P(=O)(O)O)CCOC4=CC=C(C=C4)Cl

eIF4E-IN-4

CAS: 1373822-39-9

eIF4E-IN-4 (Compound 33) is a selective inhibitor of the eukaryotic initiation factor 4E (eIF4E) with a biochemical activity value of 95 nM. It inhibits cap-dependent mRNA translation with an IC50 of 2.5 μM and is applicable in research on breast cancer, colon cancer, and head and neck cancer.

Formel: C₂₀H₁₉ClN₅O₅P

Farbe und Form: Solid

Molekulargewicht: 475.822

Ref: TM-T206372