CAS 1402802-45-2

Formel: C12H22N4O2

InChl: InChI=1S/C12H22N4O2/c1-3-4-5-9(6-7-17)15-11-10(18-2)8-14-12(13)16-11/h8-9,17H,3-7H2,1-2H3,(H3,13,14,15,16)/t9-/m0/s1

InChI Key: VHYHGSJSNJIJDN-VIFPVBQESA-N

SMILES: CCCC[C@@H](CCO)NC1=NC(=NC=C1OC)N

TLR7/8 agonist 13

CAS: 1402802-45-2

TLR7/8 agonist 13 is an orally active dual agonist of TLR7 (with a lowest effective concentration (LEC) [hTLR7] of 1.6 μM) and TLR8 (LEC [hTLR8] of 1.6 μM). It acts on human peripheral blood mononuclear cells (hPBMC) with agonistic activity (LEC [hPBMC] = 0.5 μM). In mice and cynomolgus monkeys, TLR7/8 agonist 13 induces endogenous IFNα, activates myeloid dendritic cells and monocytes, promoting their differentiation towards a TH1 phenotype. In chronic AAV-HBV mouse models, it reduces viral load and HBV surface antigen levels. TLR7/8 agonist 13 has the potential to indirectly induce IFNγ, facilitating the response of HBV antigen-specific CD8 T cells. This compound is useful for hepatitis B virus research.

Formel: C₁₂H₂₂N₄O₂

Farbe und Form: Solid

Molekulargewicht: 254.33

Ref: TM-T212528