CAS 147127-20-6

Tenofovir

Beschreibung:

Tenofovir ist ein antiretrovirales Medikament, das hauptsächlich zur Behandlung und Prävention von HIV/AIDS und chronischer Hepatitis B eingesetzt wird. Es gehört zur Klasse der Nukleotid-Reverse-Transkriptase-Inhibitoren (NRTIs) und wirkt, indem es das Enzym Reverse Transkriptase hemmt, das für die virale Replikation entscheidend ist. Die chemische Struktur von Tenofovir umfasst eine Phosphonatgruppe, die zu seinem Wirkmechanismus beiträgt. Es wird typischerweise in Form seines Disoproxilfumarats verabreicht, was seine Bioverfügbarkeit erhöht. Tenofovir ist bekannt für sein relativ günstiges Sicherheitsprofil, obwohl es mit Nierentoxizität und Verlust der Knochendichte bei einigen Patienten in Verbindung gebracht werden kann. Die Substanz ist in Wasser löslich, was ihre Formulierung in oralen Darreichungsformen erleichtert. Ihre Pharmakokinetik umfasst eine schnelle Absorption und Umwandlung in ihre aktive Form, Tenofovir Diphosphat, innerhalb der Zellen. Als wichtiger Bestandteil von Kombinationstherapien spielt Tenofovir eine bedeutende Rolle im Management von HIV-Infektionen und wird auch in der Prä-Expositions-Prophylaxe (PrEP) eingesetzt, um das Risiko einer HIV-Übertragung zu verringern.

Formel: C₉H₁₄N₅O₄P

InChl: InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1

InChI Key: InChIKey=SGOIRFVFHAKUTI-ZCFIWIBFSA-N

SMILES: C([C@H](OCP(=O)(O)O)C)N1C=2C(N=C1)=C(N)N=CN2

Synonyme:

• P-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid
• Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-
• (R)-9-(2-Phosphonomethoxypropyl)adenine
• Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-
• Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, (R)-

Tenofovir

CAS: 147127-20-6

Formel: C₉H₁₄N₅O₄P

Reinheit: >98.0%(T)(HPLC)

Farbe und Form: White to Almost white powder to crystaline

Molekulargewicht: 287.22

Ref: 3B-T3006

Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-

CAS: 147127-20-6

Formel: C₉H₁₄N₅O₄P

Reinheit: 95%

Farbe und Form: Solid

Molekulargewicht: 287.2123

Ref: IN-DA001EMI

Tenofovir

CAS: 147127-20-6

Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B.

Formel: C₉H₁₄N₅O₄P

Reinheit: 98.69% - 99.92%

Farbe und Form: White To Tan Solid Solid Powder

Molekulargewicht: 287.21

Ref: TM-T1649

Tenofovir

CAS: 147127-20-6

Formel: C₉H₁₄N₅O₄P

Farbe und Form: White To Off-White Solid

Molekulargewicht: 287.22

Ref: 4Z-T-023

Tenofovir

CAS: 147127-20-6

Tenofovir

Reinheit: 98%

Molekulargewicht: 287.21g/mol

Ref: 54-OR1030259

Tenofovir

CAS: 147127-20-6

Tenofovir

Reinheit: ≥98%

Molekulargewicht: 287.21g/mol

Ref: 54-BUP16961

Tenofovir

CAS: 147127-20-6

Formel: C₉H₁₄N₅O₄P

Reinheit: ≥ 98.0% (anhydrous)

Farbe und Form: White to off-white powder

Molekulargewicht: 287.21

Ref: 7W-GP5400

Tenofovir

CAS: 147127-20-6

Farbe und Form: Neat

Ref: 86-MM1329.19

Tenofovir

CAS: 147127-20-6

Applications Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.
References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);

Formel: C₉H₁₄N₅O₄P

Farbe und Form: White To Off-White

Molekulargewicht: 287.21

Ref: TR-T018500

Tenofovir - Bio-X ™

CAS: 147127-20-6

Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases. 
Tenofovir is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formel: C₉H₁₄N₅O₄P

Reinheit: Min. 98.5 Area-%

Farbe und Form: White To Off-White Solid

Molekulargewicht: 287.21 g/mol

Ref: 3D-BT164455

Tenofovir

CAS: 147127-20-6

Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases. An oral prodrug, used in the treatment of HIV, is tenofovir alafenamide (TAF) hemifumerate and this has improved stability, greater antiviral activity and reduces the risk of side effects such as loss of kidney function. Furthermore, TAF is easily metabolized into tenofovir in the lymphocytes allowing increased drug accumulation in HIV cells.

Formel: C₉H₁₄N₅O₄P

Reinheit: Min. 95%

Farbe und Form: White Clear Liquid

Molekulargewicht: 287.21 g/mol

Ref: 3D-FT10480

(R)-9-(2-Phosphonomethoxypropyl)adenine

CAS: 147127-20-6

Formel: C₉H₁₄N₅O₄P

Reinheit: 95%

Farbe und Form: Solid

Molekulargewicht: 287.216

Ref: 10-F077792

Tenofovir (1 mg/mL in Water)

CAS: 147127-20-6

Formel: C₉H₁₄N₅O₄P

Farbe und Form: Single Solution

Molekulargewicht: 287.21

Ref: TR-KIT7765

Dimethylaminocarboxymethyl POC Tenofovir (Mixture of Diastereomers)

Kontrolliertes Produkt

CAS: 147127-20-6

Impurity Tenofovir Impurity
Stability Light Sensitive
Applications An impurity of Tenofovir (T018500). Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent.
References Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);

Formel: C₁₈H₂₉N₆O₉P

Farbe und Form: Neat

Molekulargewicht: 504.431

Ref: TR-M540865

Tenofovir-d5

Kontrolliertes Produkt

CAS: 147127-20-6

Formel: C₉D₅H₉N₅O₄P

Farbe und Form: Neat

Molekulargewicht: 292.243

Ref: TR-T018503