CAS 1558021-37-6

TP0463518

CAS: 1558021-37-6

TP0463518

Formel: C₂₀H₁₈ClN₃O₆

Reinheit: ≥98%

Molekulargewicht: 431.83

Ref: 54-BUP06159

TP0463518

CAS: 1558021-37-6

Formel: C₂₀H₁₈ClN₃O₆

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 431.8264

Ref: IN-DA01V3Z0

TP0463518

CAS: 1558021-37-6

TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).

Formel: C₂₀H₁₈ClN₃O₆

Reinheit: 99.52%

Farbe und Form: Solid

Molekulargewicht: 431.83

Ref: TM-T5392

2-[(1-{[6-(4-chlorophenoxy)pyridin-3-yl]methyl}-2,4-dioxopiperidin-3-yl)formamido]acetic acid

CAS: 1558021-37-6

Reinheit: ≥98%

Molekulargewicht: 431.8299866

Ref: 10-F861414

TP0463518

CAS: 1558021-37-6

TP0463518 is a potent, selective inhibitor of the 11β-hydroxylase enzyme that blocks the synthesis of cortisol. This agent stabilizes the kidney cortex and protects against chronic kidney disease in a dose-dependent manner. TP0463518 has been shown to increase erythropoiesis and reduce hemoglobinuria in nephrectomized rats, as well as inhibiting renal injury caused by ischemia/reperfusion in a rat model.
TP0463518 can be used to treat patients with chronic kidney disease, such as those with polycystic kidney disease or acute renal failure. It also has potential applications for patients undergoing hemodialysis or on peritoneal dialysis.

Formel: C₂₀H₁₈ClN₃O₆

Reinheit: Min. 95%

Molekulargewicht: 431.83 g/mol

Ref: 3D-IMC02137