CAS 16009-13-5

Hemin

Beschreibung:

Hemin, mit der CAS-Nummer 16009-13-5, ist ein Häm-Derivat, das eine bedeutende Rolle in verschiedenen biochemischen Prozessen spielt. Es zeichnet sich durch sein dunkelbraunes bis schwarzes kristallines Aussehen aus und ist in organischen Lösungsmitteln wie Dimethylsulfoxid (DMSO) löslich und leicht in Wasser löslich, insbesondere bei saurem pH-Wert. Hemin ist die oxidierte Form von Häm, das ein Eisenion enthält, das an einen Porphyrinring koordiniert ist. Diese Verbindung ist bekannt für ihre Fähigkeit, an Redoxreaktionen teilzunehmen und kann als Katalysator in verschiedenen biochemischen Wegen wirken. Hemin wird häufig in Laborumgebungen für Studien im Zusammenhang mit Hämoglobin und Myoglobin sowie in der Synthese anderer hämhaltiger Verbindungen verwendet. Darüber hinaus hat es Anwendungen in der Medizin, insbesondere bei der Behandlung bestimmter Porphyrien, wo es hilft, die Häm-Synthese zu regulieren. Seine Stabilität und Reaktivität machen es zu einer wertvollen Verbindung sowohl in der Forschung als auch in klinischen Kontexten.

Formel: C₃₄H₃₀ClFeN₄O₄·2H

InChl: InChI=1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3/b25-13-,26-13?,27-14?,28-15?,29-14-,30-15-,31-16-,32-16?;;

InChI Key: InChIKey=BTIJJDXEELBZFS-KKXYAJQKSA-K

SMILES: [Cl-][Fe+3]123[N-]4C5=CC6=[N]1C(=CC=7[N-]2C(C=C8[N]3=C(C=C4C(C)=C5CCC([O-])=O)C(C=C)=C8C)=C(C=C)C7C)C(C)=C6CCC([O-])=O.[H+]

Synonyme:

• 1,3,5,8-Tetramethyl-2,4-divinylporphine-6,7-dipropionic acid ferrichloride
• 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-, iron complex
• Chloro[dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]iron
• Chlorohemin
• Chloroprotoferriheme
• Chloroprotohemin
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]-, dihydrogen, (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N²¹,N²²,N²³,N²⁴]-, dihydrogen, (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-, hydrogen (1:2), (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN²¹,κN²²,κN²³,κN²⁴]-, dihydrogen, (SP-5-13)-
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN²¹,κN²²,κN²³,κN²⁴]-, hydrogen (1:2), (SP-5-13)-
• Ferric hemin
• Ferriheme
• Ferriheme chloride
• Ferriporphyrin chloride
• Ferriprotoporphyrin
• Ferriprotoporphyrin IX
• Ferriprotoporphyrin IX chloride
• Haemin
• Hemin
• Hemin IX
• Hemin chloride
• Hemina
• Hemine
• Iron(III) protoporphyrin chloride
• Iron, chloro[dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]-
• Kjb 003
• Panhematin
• Protoferriheme
• Protohemin
• Protohemin IX
• Protohemin chloride
• Teichmann's crystals
• Ferrate(2-), chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kappaN21,kappaN22,kappaN23,kappaN24)-, hydrogen (1:2), (SP-5-13)-
• Ferrate(2-), chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kappaN21,kappaN22,kappaN23,kappaN24)-, dihydrogen, (SP-5-13)-
• Alkaline Hematin D-575
• UNII-743LRP9S7N
• AI3-18784
• Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-, dihydrogen, (SP-5-13)-
• Ferrihaem
• NSC 122707
• Teichmanns crystals
• CCRIS 7061

Hemin

CAS: 16009-13-5

Formel: C₃₄H₃₂ClFeN₄O₄

Reinheit: >95.0%(T)

Farbe und Form: Dark green to Dark purple to Black powder to crystal

Molekulargewicht: 651.95

Ref: 3B-H0008

Hemin (porcine), 97+%

CAS: 16009-13-5

Hemin is used in cellular protection and control mechanism. It stimulates the synthesis of globulin. It is also used to study the bacterial strains and growth conditions, in the short-term colony assays and cell transfections. Further, it is used to treat the symptoms of various porphyrias. In addit

Formel: C₃₄H₃₂ClFeN₄O₄

Reinheit: 97+%

Farbe und Form: Dark purple or brown to black, Crystals or powder or crystalline powder

Molekulargewicht: 651.95

Ref: 02-A11165

Hemin

CAS: 16009-13-5

Hemin

Formel: C₃₄H₃₂ClFeN₄O₄

Reinheit: 99.5%

Farbe und Form: Solid

Molekulargewicht: 651.94

Ref: 54-BUP18540

Hemin porcine

CAS: 16009-13-5

Hemin porcine

Formel: C₃₄H₃₂ClFeN₄O₄

Farbe und Form: Dark Blue Powder

Molekulargewicht: 651.94g/mol

Ref: 54-BIH1004

Hemin, 95%

CAS: 16009-13-5

Formel: C₃₄H₃₂ClFeN₄O₄

Reinheit: ≥ 95.0%

Farbe und Form: Dark blue or dark green to brown-black powder

Molekulargewicht: 651.95

Ref: 7W-GE0624

Hemin bovine

CAS: 16009-13-5

Hemin bovine

Formel: C₃₄H₃₂ClFeN₄O₄

Reinheit: 97%

Molekulargewicht: 651.95g/mol

Ref: 54-BI4570

Hemin, 98%

CAS: 16009-13-5

Formel: C₃₄H₃₂ClFeN₄O₄

Reinheit: ≥ 98%

Farbe und Form: Dark blue to brown-black powder

Molekulargewicht: 651.95

Ref: 7W-GE9985

1,3,5,8-Tetramethyl-2,4-divinylporphine-6,7-dipropionic acid ferrichloride

CAS: 16009-13-5

Formel: C₃₄H₃₂ClFeN₄O₄

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 651.9403

Ref: IN-DA00HYL2

Hemin

CAS: 16009-13-5

Formel: C₃₄H₃₂ClFeN₄O₄

Reinheit: >95%

Farbe und Form: Dark Blue

Molekulargewicht: 651.94

Ref: FT-H651-9

Hemin Chloride (Technical grade)

CAS: 16009-13-5

Applications Hemin chloride is a porphyrin complex heme oxygenase-1 inducer with acts in cellular protection and control. At a concentration of 20 mM Hemin chloride demonstrated the significance of heme in myotube maturation by increasing size, number, cross-striations, and contraction frequency and strength of myotubes. The compound has been observed to induce cGMP formation through induction of guanylate cyclase. Hemin chloride has been noted to stimulate calcium-dependent K+ channels and modulate fluid transport and Na+ in the loop of henle in rat studies. Hemin has also been documented to give rise to active chloride secretion in Caco-2 cells. In cadmium injured rat testes, hemin chloride demonstrated anti-apoptotic, antiinflamatory and antioxidant properties. Through reactive oxygen species of ERK
References Vanova, K. et al.: BMC Cancer., 16, 309 (2016); Wang, X. et al.: ACS App. Mat. Inter., 9, 25387 (2017);

Formel: C₃₄H₃₂ClFeN₄O₄

Farbe und Form: Neat

Molekulargewicht: 651.94

Ref: TR-H245648

Hemin

CAS: 16009-13-5

Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer.

Formel: C₃₄H₃₂ClFeN₄O₄

Reinheit: 97.16% - 99.97%

Farbe und Form: Black Solid

Molekulargewicht: 651.94

Ref: TM-T5515

Hemin

CAS: 16009-13-5

1,3,5,8-Tetramethyl-2,4-divinylporphine-6,7-dipropionic acid ferrichloride

Formel: C₃₄H₃₂ClFeN₄O₄

Reinheit: 97%

Molekulargewicht: 651.94

Ref: IN-DG132990

Hemin

CAS: 16009-13-5

Hemin is an iron-containing porphyrin (Fe(III) complex of protoporphyrin IX) and is present in human blood. It plays an important role in immune response by facilitating hemoglobin release, increasing the production of reactive oxygen species (ROS) and promoting bacterial lysis. Hemin is also found in Porphyromonas gingivalis and hemophilus influenza bacteria and it may play a role in their virulence since it serves as an iron source for growing cultures. However, hemin has shown antibacterial properties when it binds to serum albumin and some modified porphyrins, and has been reported to trigger cell death in Porphyromonas gingivalis (an oral pathogen) by reducing the iron uptake. This might affect the levels of free hemin that actively affect the peroxidation of low-density lipoproteins (LDL). To prevent the peroxidation, hemopexin captures these globin-free hemin by binding to it and transporting it to the liver, where it is internalized and degraded.

Formel: C₃₄H₃₂ClFeN₄O₄

Reinheit: Min. 97 Area-%

Farbe und Form: Powder

Molekulargewicht: 651.94 g/mol

Ref: 3D-FH16318

Hemin

CAS: 16009-13-5

Hemin is an iron-containing porphyrin (Fe(III) complex of protoporphyrin IX) and is present in human blood. It plays an important role in immune response by facilitating hemoglobin release, increasing the production of reactive oxygen species (ROS) and promoting bacterial lysis. Hemin is also found in Porphyromonas gingivalis and hemophilus influenza bacteria and it may play a role in their virulence since it serves as an iron source for growing cultures. However, hemin has shown antibacterial properties when it binds to serum albumin and some modified porphyrins, and has been reported to trigger cell death in Porphyromonas gingivalis (an oral pathogen) by reducing the iron uptake. This might affect the levels of free hemin that actively affect the peroxidation of low-density lipoproteins (LDL). To prevent the peroxidation, hemopexin captures these globin-free hemin by binding to it and transporting it to the liver, where it is internalized and degraded.

Formel: C₃₄H₃₂ClFeN₄O₄

Reinheit: 98.0 To 100.0 Area-%

Farbe und Form: Powder

Molekulargewicht: 651.94 g/mol

Ref: 3D-XH181795

Hemin

CAS: 16009-13-5

Formel: C₃₄H₃₂ClFeN₄O₄

Molekulargewicht: 651.9

Ref: BE-RMT13310

Hemin

CAS: 16009-13-5

Formel: C₃₄H₃₂ClFeN₄O₄

Molekulargewicht: 651.9

Ref: BE-BePure-25229

Hemin (Ferriprotoporphyrin IX chloride), min. 95%

CAS: 16009-13-5

Hemin (Ferriprotoporphyrin IX chloride), min. 95%

Formel: Fe(C₃₄H₃₂N₄O₄)Cl

Reinheit: min. 95%

Farbe und Form: black xtl.

Molekulargewicht: 651.95

Ref: 08-26-1480

Hemin Chloride cryst. ex. Porcine extrapure, 98%

CAS: 16009-13-5

Formel: C₃₄H₃₂CIFeN₄O₄

Reinheit: min. 98%

Farbe und Form: Dark brownish black to dark blue to grey, Crystalline powder

Molekulargewicht: 651.96

Ref: SR-98457

Hemin Chloride cryst. ex. Bovine extrapure, 98%

CAS: 16009-13-5

Formel: C₃₄H₃₂CIFeN₄O₄

Reinheit: min. 98 %

Farbe und Form: Dark brownish black, Crystalline powder

Molekulargewicht: 651.96

Ref: SR-78372

Hemin-d6

Kontrolliertes Produkt

CAS: 16009-13-5

Formel: C₃₄D₆H₂₆ClFeN₄O₄

Farbe und Form: Neat

Molekulargewicht: 657.977

Ref: TR-H245647