CAS 1802068-51-4

Formel: C22H16N6

InChl: InChI=1S/C22H16N6/c1-2-6-15(7-3-1)19-14-20(28-27-19)25-22-17-8-4-5-9-18(17)24-21(26-22)16-10-12-23-13-11-16/h1-14H,(H2,24,25,26,27,28)

InChI Key: OMNOGBPVYFVKRM-UHFFFAOYSA-N

SMILES: C1=CC=C(C=C1)C2=CC(=NN2)NC3=NC(=NC4=CC=CC=C43)C5=CC=NC=C5

UNI418

CAS: 1802068-51-4

UNI418 is a dual inhibitor targeting PIKfyve and PIP5K1C, exhibiting antiviral activity against SARS-CoV-2 (EC50=1.4 μM). It inhibits the endocytosis of the virus mediated by ACE2 by suppressing PIP5K1C (IC₅₀=60.1 nM; Kd=61 nM). Additionally, UNI418 impedes the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic activation regulated by PIKfyve (Kd=0.78 nM).

Formel: C₂₂H₁₆N₆

Farbe und Form: Solid

Molekulargewicht: 364.40

Ref: TM-T200240