CAS 1818339-66-0

Formel: C18H19F2N5O3S2

InChl: InChI=1S/C18H19F2N5O3S2/c1-9-4-10-6-30-17(21)25-18(10,8-27-9)15-24-13(7-29-15)23-14(26)12-3-2-11(5-22-12)28-16(19)20/h2-3,5,7,9-10,16H,4,6,8H2,1H3,(H2,21,25)(H,23,26)/t9-,10-,18-/m0/s1

InChI Key: ZLZUHACSRMOLLV-RAALSFIWSA-N

SMILES: C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=NC(=CS3)NC(=O)C4=NC=C(C=C4)OC(F)F)N

N-(2-((4aR,6S,8aR)-2-Amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide

CAS: 1818339-66-0

N-(2-((4aR,6S,8aR)-2-Amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide

Formel: C₁₈H₁₉F₂N₅O₃S₂

Reinheit: 99.23%

Molekulargewicht: 455.51

Ref: 54-PC1005767

N-(2-((4Ar,6S,8Ar)-2-Amino-6-Methyl-4,4a,5,6-Tetrahydropyrano[3,4-D][1,3]Thiazin-8A(8H)-Yl)Thiazol-4-Yl)-5-(Difluoromethoxy)Picolinamide

CAS: 1818339-66-0

Formel: C₁₈H₁₉F₂N₅O₃S₂

Reinheit: 99.23%

Farbe und Form: Solid

Molekulargewicht: 455.5020

Ref: IN-DA00234K

N-(2-((4aR,6S,8aR)-2-Amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide

CAS: 1818339-66-0

N-(2-((4aR,6S,8aR)-2-Amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide

Formel: C₁₈H₁₉F₂N₅O₃S₂

Reinheit: 98%

Molekulargewicht: 455.5

Ref: IN-DG00784322

PF-06751979

CAS: 1818339-66-0

PF-06751979 is a nonselective, aspartyl protease inhibitor that has been shown to penetrate the cerebral cortex and cause a decrease in the amount of neurofibrillary tangles (NFTs) found in the brain. It also causes an increase in the amount of pigmented neurons in the cerebral cortex, which may be related to its ability to inhibit NFT production. PF-06751979 is being developed for the treatment of Alzheimer's disease and other diseases with neuropathological features, such as Parkinson's disease and Huntington's disease.

Formel: C₁₈H₁₉F₂N₅O₃S₂

Reinheit: Min. 95%

Molekulargewicht: 455.5 g/mol

Ref: 3D-TXC33966

PF-06751979

CAS: 1818339-66-0

PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).

Formel: C₁₈H₁₉F₂N₅O₃S₂

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 455.502

Ref: TM-T12429