CAS 190841-57-7

Formel: C22H24Cl2N2O

InChl: InChI=1S/C22H22N2O.2ClH/c25-22(15-24-12-9-20(22)10-13-24)19-6-3-16(4-7-19)17-5-8-21-18(14-17)2-1-11-23-21;;/h1-8,11,14,20,25H,9-10,12-13,15H2;2*1H

InChI Key: ALEHEGZTOBQIGC-UHFFFAOYSA-N

SMILES: C1CN2CCC1C(C2)(C3=CC=C(C=C3)C4=CC5=C(C=C4)N=CC=C5)O.Cl.Cl

RPR107393

CAS: 190841-57-7

RPR107393 is an orally active and selective inhibitor of squalene synthase (SQS). It inhibits squalene synthase in rat liver microsomes with an IC₅₀ of 0.8 nM. By increasing cellular farnesol and its derivatives, RPR107393 suppresses fatty acid biosynthesis, thereby reducing triglyceride synthesis. It also lowers plasma cholesterol in rats and marmosets. RPR107393 is applicable in research related to metabolic diseases, such as hypercholesterolemia, hypertriglyceridemia, and atherosclerosis ^[1][2].

Formel: C₂₂H₂₄Cl₂N₂O

Molekulargewicht: 403.35

Ref: TM-T213660