CAS 1968-05-4

3,3'-Diindolylmethan

Beschreibung:

3,3'-Diindolylmethan (DIM) ist eine organische Verbindung, die aus Indol abgeleitet ist und spezifisch durch die Dimerisierung von Indol-3-Carbinol gebildet wird, das in Kreuzblütlern wie Brokkoli und Rosenkohl vorkommt. Es ist gekennzeichnet durch seine zwei Indolringe, die durch eine Methylenbrücke verbunden sind. DIM ist bekannt für seine potenziellen gesundheitlichen Vorteile, insbesondere im Kontext der Krebsprävention und des hormonellen Gleichgewichts, da es den Östrogenstoffwechsel beeinflussen und entzündungshemmende Eigenschaften aufweisen kann. Die Verbindung ist typischerweise ein gelb bis orangefarbener kristalliner Feststoff und in organischen Lösungsmitteln löslich, hat jedoch eine begrenzte Löslichkeit in Wasser. Seine chemische Formel ist C18H16N2 und es hat ein relativ niedriges Molekulargewicht. DIM hat in der ernährungswissenschaftlichen und pharmazeutischen Forschung aufgrund seiner bioaktiven Eigenschaften Interesse geweckt, und Studien haben seine Rolle bei der Modulation verschiedener biologischer Wege, einschließlich Apoptose und Zellzyklusregulation, untersucht. Weitere Forschung ist jedoch erforderlich, um seine Mechanismen und therapeutischen Potenziale vollständig zu verstehen.

Formel: C₁₇H₁₄N₂

InChl: InChI=1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2

InChI Key: InChIKey=VFTRKSBEFQDZKX-UHFFFAOYSA-N

SMILES: C(C=1C=2C(NC1)=CC=CC2)C=3C=4C(NC3)=CC=CC4

Synonyme:

• 1H-Indole, 3,3′-methylenebis-
• 3,3'-Methylenebisindole
• 3,3'-methanediylbis(1H-indole)
• 3,3'Diindolemethane
• 3,3-Methylenediindole
• 3,3′-Bisindolylmethane
• 3,3′-Methanediyldi(1H-indole)
• 3,3′-Methylenebis[1H-indole]
• 3-[(1H-Indol-3-yl)methyl]-1H-indole
• Arundine
• Bis(1H-indol-3-yl)methane
• Bis(3-indolyl)methane
• Cervicon-DIM
• DIM
• DIM (AhR agonist)
• DIM (diindolylmethane)
• Di(1H-indol-3-yl)methane
• Diindolylmethane
• Diindoylmethane
• Hb 236
• Indole, 3,3′-methylenedi-
• Infemin
• 3,3-Diindolylmethane

3,3'-Methylenediindole

CAS: 1968-05-4

Formel: C₁₇H₁₄N₂

Reinheit: >98.0%(N)

Farbe und Form: White to Light yellow to Light red powder to crystal

Molekulargewicht: 246.31

Ref: 3B-M1399

3,3'-Diindolylmethane

CAS: 1968-05-4

3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent.

Formel: C₁₇H₁₄N₂

Reinheit: 99.09%

Farbe und Form: Solid

Molekulargewicht: 246.31

Ref: TM-T2991

3,3'-Diindolylmethane

CAS: 1968-05-4

3,3'-Diindolylmethane

Formel: C₁₇H₁₄N₂

Reinheit: ≥98%

Molekulargewicht: 246.31

Ref: 54-BUP14951

3,3'-Bisindolylmethane

CAS: 1968-05-4

Formel: C₁₇H₁₄N₂

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 246.3065

Ref: IN-DA003BAM

3,3-MethylenedIIndole

CAS: 1968-05-4

3,3-MethylenedIIndole

Formel: C₁₇H₁₄N₂

Reinheit: >98%

Molekulargewicht: 246.31

Ref: 54-OR1010762

3,3''-Diindolylmethane

CAS: 1968-05-4

Formel: C₁₇H₁₄N₂

Reinheit: ≥ 98.0% (anhydrous basis)

Farbe und Form: White to off-white crystalline powder

Molekulargewicht: 246.31

Ref: 7W-GK6642

3,3'-Diindolylmethane

Kontrolliertes Produkt

CAS: 1968-05-4

Applications 3,3'-Diindolylmethane is an activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. 3,3'-Diindolylmethane is an antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.
References Kandala, et al.: Mol.Pharmacol., 78, 297 (2010), Kandala, et al.: J. Pharmacol. Exp. Ther., 341 24 (2012),

Formel: C₁₇H₁₄N₂

Farbe und Form: Neat

Molekulargewicht: 246.31

Ref: TR-D455190

Bis (3-indolyl)methane

CAS: 1968-05-4

Formel: C₁₇H₁₄N₂

Reinheit: 98%

Farbe und Form: Solid, White to pale reddish yellow powder

Molekulargewicht: 246.313

Ref: 10-F024220

3,3'-Diindolymethane (synthetic)

CAS: 1968-05-4

3,3'-Diindolylmethane, also known as DIM, is natural compound derived from indole. In a recent study, DIM was evaluated as a potential agent for preventing biofilm formation by Streptococcus mutans, which is a major cause of dental caries. The researchers found that DIM significantly inhibited biofilm formation (by 92%) and reduced the production of extracellular polymeric substances (EPS), which are important for biofilm stability particularly under acidic conditions. The study suggests that 3,3'-diindolylmethane has anti-biofilm and anti-virulence properties against S. mutans, and it is a potential candidate for reducing biofilm formation and preventing dental caries.
It has been also reported that 3,3'-diindolymethane can act as a chemopreventive agent. DIM has estrogenic effects without interacting with the binding domain of the estrogen receptors. This study found that DIM could suppress cell growth and disrupt cell cycle progression of young adult mouse colonocytes (YAMCs) in vitro. Moreover, DIM altered gene expression associated with apoptosis and cell proliferation, and it induced transcriptional activity of the estrogen receptor (ER), which was inhibited by an ER antagonist.

Formel: C₁₇H₁₄N₂

Reinheit: Min. 95%

Farbe und Form: Powder

Molekulargewicht: 246.31 g/mol

Ref: 3D-FD14886

3,3'-Diindolylmethane

CAS: 1968-05-4

3,3'-Diindolylmethane

Formel: C₁₇H₁₄N₂

Reinheit: 98%

Molekulargewicht: 246.31

Ref: IN-DG8848

3,3'-Diindolymethane (natural)

CAS: 1968-05-4

3,3'-Diindolylmethane, also known as DIM, is natural compound derived from indole. In a recent study, DIM was evaluated as a potential agent for preventing biofilm formation by Streptococcus mutans, which is a major cause of dental caries. The researchers found that DIM significantly inhibited biofilm formation (by 92%) and reduced the production of extracellular polymeric substances (EPS), which are important for biofilm stability particularly under acidic conditions. The study suggests that 3,3'-diindolylmethane has anti-biofilm and anti-virulence properties against S. mutans, and it is a potential candidate for reducing biofilm formation and preventing dental caries. It has been also reported that 3,3'-diindolymethane can act as a chemopreventive agent. DIM has estrogenic effects without interacting with the binding domain of the estrogen receptors. This study found that DIM could suppress cell growth and disrupt cell cycle progression of young adult mouse colonocytes (YAMCs) in vitro. Moreover, DIM altered gene expression associated with apoptosis and cell proliferation, and it induced transcriptional activity of the estrogen receptor (ER), which was inhibited by an ER antagonist.

Formel: C₁₇H₁₄N₂

Reinheit: Min. 95%

Farbe und Form: Powder

Molekulargewicht: 246.31 g/mol

Ref: 3D-FD14887