CAS 2130846-15-8

Formel: C70H101N15O24S3

InChl: InChI=1S/C70H101N15O24S3/c1-33(2)25-47(82-69(107)56(35(4)87)74-37(6)89)63(101)83-51(31-86)67(105)80-49(27-39-30-72-42-12-10-9-11-41(39)42)65(103)79-48-26-38-13-15-40(16-14-38)109-21-24-112-32-52(68(106)85-57(36(5)88)70(108)78-46(58(71)96)28-54(92)93)84-62(100)45(20-23-111-8)77-66(104)50(29-55(94)95)81-61(99)44(19-22-110-7)75-59(97)34(3)73-60(98)43(76-64(48)102)17-18-53(90)91/h9-16,30,33-36,43-52,56-57,72,86-88H,17-29,31-32H2,1-8H3,(H2,71,96)(H,73,98)(H,74,89)(H,75,97)(H,76,102)(H,77,104)(H,78,108)(H,79,103)(H,80,105)(H,81,99)(H,82,107)(H,83,101)(H,84,100)(H,85,106)(H,90,91)(H,92,93)(H,94,95)/t34-,35+,36+,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,56-,57-/m0/s1

InChI Key: WASVHPKZZJQGTJ-UDFCJKPSSA-N

SMILES: C[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSCCOC2=CC=C(C[C@@H](C(=O)N[C@H](C(=O)N1)CCC(=O)O)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)C)C=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N)CCSC)CC(=O)O)CCSC

HL2-m5

CAS: 2130846-15-8

HL2-m5 is an inhibitor of the sonic hedgehog/patched (Shh/PTCH1) interaction, with a Kd for Shh of 170 nM. It effectively inhibits the activation of the Hedgehog signaling pathway and the transcription of Gli-controlled genes, with an IC₅₀ of 230 nM.

Formel: C₇₀H₁₀₁N₁₅O₂₄S₃

Farbe und Form: Solid

Molekulargewicht: 1632.83

Ref: TM-TP3102