CAS 2225868-19-7

123B9

Formel: C₅₈H₈₂ClFN₁₂O₂₀

InChl: InChI=1S/C58H82ClFN12O20/c1-5-6-9-36(50(83)64-37(18-21-73)51(84)68-40(25-74)48(61)81)65-55(88)44-11-8-20-72(44)58(91)47(29(2)3)70-54(87)42(27-76)69-52(85)38(24-46(79)80)66-56(89)43-10-7-19-71(43)57(90)39(22-31-12-14-32(77)15-13-31)67-49(82)30(4)62-53(86)41(26-75)63-45(78)28-92-33-16-17-35(60)34(59)23-33/h12-17,23,29-30,36-44,47,73-77H,5-11,18-22,24-28H2,1-4H3,(H2,61,81)(H,62,86)(H,63,78)(H,64,83)(H,65,88)(H,66,89)(H,67,82)(H,68,84)(H,69,85)(H,70,87)(H,79,80)/t30-,36-,37-,38-,39-,40-,41-,42-,43-,44-,47-/m0/s1

InChI Key: ZXZGKHQTGOWDLQ-PEGXCLLXSA-N

SMILES: CCCC[C@@H](C(=O)N[C@@H](CCO)C(=O)N[C@@H](CO)C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)COC4=CC(=C(C=C4)F)Cl

Synonyme:

• 123B9

123B9

CAS: 2225868-19-7

123B9 is a tumor-homing agent characterized as a potent and selective agonist for EphA2 with a dissociation constant (Kd) of 4.0 μM. It specifically targets the ligand-binding domain of the EphA2 tyrosine kinase receptor. Notably, 123B9 does not significantly inhibit the ligand-binding domains of closely related receptors EphA3 and EphA4.

Formel: C₅₈H₈₂ClFN₁₂O₂₀

Molekulargewicht: 1321.79

Ref: TM-TP2771