CAS 2230581-03-8

1H-Benzotriazole-5-propanoic acid, β-[5-chloro-4-[[(4R)-4-ethyl-3,4-dihydro-1,1-dioxido-2H-5,1,2-benzoxathiazepin-2-yl]methyl]-2-thienyl]-1-ethyl-α,α,4-trimethyl-, (βS)-

Formel: C₂₉H₃₃ClN₄O₅S₂

InChl: InChI=1S/C29H33ClN4O5S2/c1-6-19-16-33(41(37,38)24-11-9-8-10-22(24)39-19)15-18-14-23(40-27(18)30)25(29(4,5)28(35)36)20-12-13-21-26(17(20)3)31-32-34(21)7-2/h8-14,19,25H,6-7,15-16H2,1-5H3,(H,35,36)/t19-,25-/m1/s1

InChI Key: JUOIJFQBEIZEMD-KBMIEXCESA-N

SMILES: CC[C@@H]1CN(S(=O)(=O)C2=CC=CC=C2O1)CC3=C(SC(=C3)[C@@H](C4=C(C5=C(C=C4)N(N=N5)CC)C)C(C)(C)C(=O)O)Cl

Synonyme:

• 1H-Benzotriazole-5-propanoic acid, β-[5-chloro-4-[[(4R)-4-ethyl-3,4-dihydro-1,1-dioxido-2H-5,1,2-benzoxathiazepin-2-yl]methyl]-2-thienyl]-1-ethyl-α,α,4-trimethyl-, (βS)-

NFE2L2 activator 3

CAS: 2230581-03-8

NFE2L2 activator 3 (Compound 3) is an activator of NFE2L2/NRF2, specifically enhancing the activity of NAD(P)H:quinone oxidoreductase (NQO1), with an EC₅₀ of less than 1 nM. It is useful for researching respiratory diseases such as chronic obstructive pulmonary disease.

Formel: C₂₉H₃₃ClN₄O₅S₂

Molekulargewicht: 617.18

Ref: TM-T218199