CAS 2378258-52-5

Formel: C53H62N10O10

InChl: InChI=1S/C53H62N10O10/c1-3-47(65)62-22-21-61(31-36(62)16-18-54)49-40-17-20-60(44-13-6-9-35-8-4-5-10-39(35)44)33-43(40)56-53(58-49)73-34-37-30-38(32-59(37)2)72-29-28-71-27-26-70-25-24-69-23-19-55-42-12-7-11-41-48(42)52(68)63(51(41)67)45-14-15-46(64)57-50(45)66/h3-13,36-38,45,55H,1,14-17,19-34H2,2H3,(H,57,64,66)/t36-,37-,38+,45?/m0/s1

InChI Key: KGFCORDWMRCVAC-VYIZRSQBSA-N

SMILES: CN1C[C@@H](C[C@H]1COC2=NC3=C(CCN(C3)C4=CC=CC5=CC=CC=C54)C(=N2)N6CCN([C@H](C6)CC#N)C(=O)C=C)OCCOCCOCCOCCNC7=CC=CC8=C7C(=O)N(C8=O)C9CCC(=O)NC9=O

PROTAC K-Ras Degrader-1

CAS: 2378258-52-5

PROTAC K-Ras Degrader-1

Formel: C₅₃H₆₂N₁₀O₁₀

Reinheit: 98.05%

Molekulargewicht: 999.12

Ref: 54-OR1112766

PROTAC K-Ras Degrader-1

CAS: 2378258-52-5

PROTAC K-Ras Degrader-1 is a PROTAC degrader based on the Cereblon E3 ligase ligand, capable of degrading K-Ras.

Formel: C₅₃H₆₂N₁₀O₁₀

Reinheit: 98.05%

Farbe und Form: Solid

Molekulargewicht: 999.12

Ref: TM-T13844

PROTAC K-Ras Degrader-1

CAS: 2378258-52-5

Formel: C₅₃H₆₂N₁₀O₁₀

Reinheit: 98.05%

Molekulargewicht: 999.1204

Ref: IN-DA01N1AN

PROTAC K-Ras Degrader-1

CAS: 2378258-52-5

Formel: C₅₃H₆₂N₁₀O₁₀

Molekulargewicht: 999.14

Ref: 4Z-P-346010

Protac K-ras degrader-1

CAS: 2378258-52-5

PROTAC K-RAS degrader-1, a proteolysis-targeting chimera (PROTAC), is a potent and selective proteolysis-targeting chimera (PROTAC) designed to degrade the K-RAS G12C mutant protein. This heterobifunctional small molecule is composed of a cereblon (CRBN) E3 ligand that binds to the CRBN E3 ubiquitin ligase complex, a linker region, and a K-RAS-binding moiety that selectively recognizes and binds to the K-RAS G12C mutant protein. Upon binding to CRBN and K-RAS G12C, PROTAC K-RAS degrader-1 acts as a molecular glue, bringing the E3 ligase close to K-RAS, leading to its ubiquitination and subsequent proteasomal degradation. Preclinical studies have demonstrated its potent degradation efficacy in K-RAS G12C-driven cancer cell lines, leading to inhibition of cell proliferation and tumor regression in xenograft models, offering a promising therapeutic approach for the treatment of K-RAS-driven cancers by directly degrading the oncogenic driver K-RAS(G12C) protein.

Formel: C₅₃H₆₂N₁₀O₁₀

Reinheit: Min. 95%

Molekulargewicht: 999.1 g/mol

Ref: 3D-DVD25852