CAS 2414373-42-3

DUN73423

CAS: 2414373-42-3

DUN73423

Formel: C₁₉H₁₆N₆O

Reinheit: ≥98%

Molekulargewicht: 344.37

Ref: 54-BUP07954

4-5-(4-Pyridylmethylamino)pyrazolo1,5-apyrimidin-3-ylbenzamide

CAS: 2414373-42-3

Selective inhibitor of the mutated RET variant RETV804M, which is the anticipated drug-resistant RET mutant that can occur in tumours treated with kinase inhibitors. The compound has a biochemical IC50 of 0.02 µM and selectivity for purified RETV804M over purified RET and KDR of 3.7 and 110, respectively. The efficacy of the compound was shown also in cell cultures with IC50 of 4.4 µM, and cell assay selectivity for RETV804M over RET and KDR of 0.89 and 2.3, respectively.

Reinheit: Min. 98 Area-%

Farbe und Form: Powder

Molekulargewicht: 344.37 g/mol

Ref: 3D-EP176312

DUN73423

CAS: 2414373-42-3

DUN73423 (RET-IN-21) is a potent tyrosine kinase (RET) inhibitor with antitumour activity for the study of cancer.

Formel: C₁₉H₁₆N₆O

Reinheit: 98.03%

Farbe und Form: Solid

Molekulargewicht: 344.37

Ref: TM-T69644