CAS 2414909-94-5

Formel: C19H16N6O

InChl: InChI=1S/C19H16N6O/c20-18(26)15-5-3-14(4-6-15)16-12-23-25-9-7-17(24-19(16)25)22-11-13-2-1-8-21-10-13/h1-10,12H,11H2,(H2,20,26)(H,22,24)

InChI Key: LMGXQBQAUALFTB-UHFFFAOYSA-N

SMILES: C1=CC(=CN=C1)CNC2=NC3=C(C=NN3C=C2)C4=CC=C(C=C4)C(=O)N

RET V804M-IN-1

CAS: 2414909-94-5

RET V804M-IN-1

Formel: C₁₉H₁₆N₆O

Reinheit: ≥95%

Molekulargewicht: 344.37

Ref: 54-BUP12576

4-(5-((Pyridin-3-Ylmethyl)Amino)Pyrazolo[1,5-A]Pyrimidin-3-Yl)Benzamide

CAS: 2414909-94-5

4-(5-((Pyridin-3-Ylmethyl)Amino)Pyrazolo[1,5-A]Pyrimidin-3-Yl)Benzamide

Formel: C₁₉H₁₆N₆O

Reinheit: >98%

Molekulargewicht: 344.37

Ref: 54-OR1024325

4-[5-(3-Pyridylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]benzamide

CAS: 2414909-94-5

Formel: C₁₉H₁₆N₆O

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 344.3699

Ref: IN-DA01KKND

RET V804M-IN-1

CAS: 2414909-94-5

4-(5-((Pyridin-3-ylmethyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)benzamide

Formel: C₁₉H₁₆N₆O

Reinheit: 98+%

Molekulargewicht: 344.37

Ref: IN-DG01217581

RET V804M-IN-1

CAS: 2414909-94-5

RET V804M-IN-1 (RETV804M kinase inhibitor) is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).

Formel: C₁₉H₁₆N₆O

Reinheit: 97.94% - 99.62%

Farbe und Form: White Solid

Molekulargewicht: 344.3699

Ref: TM-T8467

4-(5-((PYRIDIN-3-YLMETHYL)AMINO)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)BENZAMIDE

CAS: 2414909-94-5

Reinheit: 98+%

Molekulargewicht: 344.3779907

Ref: 10-F840947

RET V804M-IN-1

CAS: 2414909-94-5

Selective inhibitor of the mutated RET variant RETV804M, which is the anticipated drug-resistant RET mutant that can occur in tumours treated with kinase inhibitors. The compound has a biochemical IC50 of 0.02 µM and selectivity for purified RETV804M over purified RET and KDR of 3.7 and 110, respectively. The efficacy of the compound was shown also in cell cultures with IC50 of 4.4 µM, and cell assay selectivity for RETV804M over RET and KDR of 0.89 and 2.3, respectively.

Formel: C₁₉H₁₆N₆O

Reinheit: Min. 97 Area-%

Farbe und Form: White Powder

Molekulargewicht: 344.37 g/mol

Ref: 3D-EP176311