CAS 2504949-52-2

DGY-09-192

CAS: 2504949-52-2

DGY-09-192 is a PROTAC FGFR1/2 degrader with DC50 values of 4.35 nM for FGFR1 and 70 nM for FGFR2. It selectively degrades wild-type FGFR1/2 and various FGFR2 fusion proteins, including FGFR2-PHGDH and FGFR2-OPTN. In both in vitro and in vivo studies, DGY-09-192 inhibits downstream FGFR signaling pathways by reducing the phosphorylation of FRS2Y196 and ERK1/2T202/Y204.

Formel: C₄₉H₅₉Cl₂N₁₁O₇S

Molekulargewicht: 1017.04

Ref: TM-T215174