CAS 2761881-65-4
:Formel:C34H36N2O9
InChl:InChI=1S/C34H36N2O9/c1-5-43-31(39)34(32(40)44-6-2)33(23-14-10-11-15-24(23)35-30(33)38)26(19-12-8-7-9-13-19)27(36-34)21-17-16-20-22(28(37)41-3)18-45-29(42-4)25(20)21/h7-15,17-18,20,25-27,29,36H,5-6,16H2,1-4H3,(H,35,38)/t20-,25+,26-,27-,29-,33-/m1/s1
InChI Key:NRMOOGPJAZUIPS-PXPWCYOASA-N
SMILES:CCOC(=O)C1([C@@]2([C@@H]([C@H](N1)C3=CC[C@H]4[C@@H]3[C@@H](OC=C4C(=O)OC)OC)C5=CC=CC=C5)C6=CC=CC=C6NC2=O)C(=O)OCC
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P-gp-IN-30
CAS:P-gp-IN-30 (Compound 13) is an inhibitor of P-glycoprotein (P-gp) that targets YB-1. It reduces the expression of total YB-1 protein and nuclear YB-1 protein, thereby inhibiting the expression and function of downstream P-gp, which significantly enhances sensitivity to paclitaxel by inhibiting its efflux rate. When combined with paclitaxel, P-gp-IN-30 effectively suppresses tumor growth in A549/Taxol xenograft mouse models. This compound is useful for research on non-small cell lung cancer (NSCLC).Formel:C34H36N2O9Molekulargewicht:616.66
