CAS 282536-25-8

PNU-183792

CAS: 282536-25-8

PNU-183792 is a 4-oxo-1,4-dihydroquinoline that acts as an orally active inhibitor of herpesvirus polymerases (HSV polymerases). It exhibits broad-spectrum antiviral activity, with IC50 values of 0.69 μM for human cytomegalovirus (HCM), 0.37 μM for varicella-zoster virus, and 0.58 μM for herpes simplex virus (HSV) polymerase. PNU-183792 shows no activity against human α, γ, and δ polymerases but inhibits simian varicella virus (SVV), murine cytomegalovirus (MCMV), and rat cytomegalovirus (RCMV).

Formel: C₂₃H₂₄ClN₃O₃

Molekulargewicht: 425.91

Ref: TM-T211119