CAS 2957895-40-6

Formel: C21H20N6O3

InChl: InChI=1S/C21H20N6O3/c22-18(29)21-26-25-20(30-21)15-11-23-27-17(28)10-16(24-19(15)27)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h6-12,23H,1-5H2,(H2,22,29)

InChI Key: LYGVANBJVUFZNA-UHFFFAOYSA-N

SMILES: C1CCC(CC1)C2=CC=C(C=C2)C3=CC(=O)N4C(=N3)C(=CN4)C5=NN=C(O5)C(=O)N

YAP/TEAD-IN-2-1

CAS: 2957895-40-6

YAP/TEAD-IN-2 (Compound T-1) is an inhibitor of YAP/TEAD. This compound suppresses luciferase activity driven by YAP/TEAD in 293T cells and exhibits strong antiproliferative effects on human pleural mesothelioma NCI-H226 cells. YAP/TEAD-IN-2 is applicable for studying diseases associated with disruptions in the Hippo pathway, particularly cancer.

Formel: C₂₁H₂₀N₆O₃

Molekulargewicht: 404.43

Ref: TM-T213630