CAS 3036009-40-9

Formel: C40H47FN6O4

InChl: InChI=1S/C40H47FN6O4/c41-38-33(5-3-15-43-38)30-21-34(39(42)44-22-30)40(50)45-35-6-2-8-37(35)51-25-26-9-11-27(12-10-26)28-13-14-32-29(20-28)4-1-7-36(32)47-18-16-46(17-19-47)23-31(49)24-48/h3,5,9-15,20-22,31,35-37,48-49H,1-2,4,6-8,16-19,23-25H2,(H2,42,44)(H,45,50)/t31-,35-,36-,37-/m0/s1

InChI Key: LYOFWWMIRHDSLV-AKQLPAHTSA-N

SMILES: C1C[C@@H]([C@H](C1)OCC2=CC=C(C=C2)C3=CC4=C(C=C3)[C@H](CCC4)N5CCN(CC5)C[C@@H](CO)O)NC(=O)C6=C(N=CC(=C6)C7=C(N=CC=C7)F)N

MerTK/Axl-IN-1

CAS: 3036009-40-9

MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual inhibitor of MerTK/Axl, exhibiting IC₅₀ values of 4.2 nM and 8.8 nM in Ba/F3 cells, and 0.2 nM and 0.9 nM in HTRF cells, respectively. It effectively inhibits pMerTK in vivo and possesses a long half-life and high oral bioavailability.

Formel: C₄₀H₄₇FN₆O₄

Farbe und Form: Solid

Molekulargewicht: 694.84

Ref: TM-T200517