CAS 3052947-04-0

GRK2 degrader-1

CAS: 3052947-04-0

GRK2 degrader-1 (compound 1) is a potent and orally active GRK2 degrader. It facilitates the degradation of GRK2 via the ubiquitin-proteasome pathway. In a pulmonary arterial hypertension (PAH) mouse model, GRK2 degrader-1 inhibits right ventricular remodeling and the increase in pulmonary arterial pressure. This compound is suitable for research in pulmonary arterial hypertension (PAH).

Formel: C₂₅H₂₂N₄O₄S

Molekulargewicht: 474.54

Ref: TM-TYD-05426