CAS 3056647-52-7

Formel: C45H41FN10O5

InChl: InChI=1S/C45H41FN10O5/c46-36-22-30(38-25-49-45-48-24-32(56(45)51-38)21-28-3-8-37-29(20-28)2-1-13-47-37)4-6-34(36)42(59)54-14-11-27(12-15-54)26-52-16-18-53(19-17-52)31-5-7-33-35(23-31)44(61)55(43(33)60)39-9-10-40(57)50-41(39)58/h1-8,13,20,22-25,27,39H,9-12,14-19,21,26H2,(H,50,57,58)

InChI Key: YSTQEPBPZJFTEG-UHFFFAOYSA-N

SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)N4CCN(CC4)CC5CCN(CC5)C(=O)C6=C(C=C(C=C6)C7=NN8C(=CN=C8N=C7)CC9=CC1=C(C=C9)N=CC=C1)F

PROTAC c-Met degrader-1

CAS: 3056647-52-7

PROTACc-Met degrader-1 (Compound Met-DD4) is an orally effective PROTAC degrader targeting c-Met with a DC50 of 6.21 nM. It inhibits the proliferation of c-Met-addicted MKN-45 cells with an IC₅₀ of 4.37 nM and causes cell cycle arrest in the G0/G1 phase. In a xenograft mouse model using MKN-45 cells, PROTACc-Met degrader-1 demonstrates antitumor activity.

Formel: C₄₅H₄₁FN₁₀O₅

Farbe und Form: Solid

Molekulargewicht: 820.87

Ref: TM-T201057