CAS 3063042-81-6

Formel: C18H18O4

InChl: InChI=1S/C18H18O4/c1-20-12-6-4-11(5-7-12)14-10-16(19)15-8-13(21-2)9-17(22-3)18(14)15/h4-9,14H,10H2,1-3H3/t14-/m1/s1/i2D3,3D3

InChI Key: OYJBHGSSAJNKJF-CJXDAKJFSA-N

SMILES: [2H]C([2H])([2H])OC1=CC2=C([C@H](CC2=O)C3=CC=C(C=C3)OC)C(=C1)OC([2H])([2H])[2H]

(R)-STU104-D6

CAS: 3063042-81-6

(R)-STU104-D6 is a deuterium-labeled variant of  (R)-STU104 (T60657). This compound acts as a potent and orally active inhibitor of the interaction between TAK1 and MKK3 proteins, exhibiting IC₅₀ values of 0.58 μM for TNF-α and 4.0 μM for MKK3 phosphorylation. By binding to MKK3, (R)-STU104 hinders TAK1's ability to phosphorylate MKK3, thereby disrupting the TAK1/MKK3/p38/MnK1/MK2/elF4E signaling pathway. It is utilized in research related to ulcerative colitis.

Formel: C₁₈H₁₈₂D₆O₄

Farbe und Form: Solid

Molekulargewicht: 304.37

Ref: TM-T207425