CAS 3077918-47-6

Formel: C53H60Cl2F2N8O9

InChl: InChI=1S/C53H60Cl2F2N8O9/c1-6-38-47(48(59)65-51(60)63-38)74-21-8-20-73-40-17-14-33(25-30(40)12-18-43(66)67)72-24-23-71-22-19-61-49(68)31-11-16-39(41(26-31)70-5)62-50(69)46-44(34-9-7-10-36(55)45(34)57)53(29-58,42(64-46)28-52(2,3)4)35-15-13-32(54)27-37(35)56/h7,9-11,13-17,25-27,42,44,46,64H,6,8,12,18-24,28H2,1-5H3,(H,61,68)(H,62,69)(H,66,67)(H4,59,60,63,65)/t42-,44-,46+,53-/m0/s1

InChI Key: IXFZWVFOAUJQKN-DLIBPESQSA-N

SMILES: CCC1=C(C(=NC(=N1)N)N)OCCCOC2=C(C=C(C=C2)OCCOCCNC(=O)C3=CC(=C(C=C3)NC(=O)[C@H]4[C@@H]([C@@]([C@@H](N4)CC(C)(C)C)(C#N)C5=C(C=C(C=C5)Cl)F)C6=C(C(=CC=C6)Cl)F)OC)CCC(=O)O

PROTAC DHFR Degrader-1

CAS: 3077918-47-6

PROTAC DHFR Degrader-1 is a PROTAC degrader that specifically targets the dihydrofolate reductase-thymidylate synthase (DHFR-TS) of Plasmodium falciparum, with a Ki value of 2.01 nM. It shows no inhibitory activity against human DHFR and can inhibit the growth of Plasmodium falciparum, making it useful for research on Plasmodium falciparum and malaria.

Formel: C₅₃H₆₀Cl₂F₂N₈O₉

Molekulargewicht: 1062.00

Ref: TM-T218459