CAS 3092208-36-8

DFCI-002-06

CAS: 3092208-36-8

DFCI-002-06 is an orally active dual-targeted HCK/BTK PROTAC degrader, demonstrating DC₅₀ values of 1.3 nM for HCK and 4.5 nM for BTK. It retains superior antitumor activity compared to dual-targeted HCK/BTK inhibitors and induces apoptosis in cancer cells. DFCI-002-06 is applicable in studies of MYD88-mutant B-cell malignancies.

Formel: C₄₄H₄₆N₁₀O₅

Molekulargewicht: 794.92

Ref: TM-T217183